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Revisiting the notion of deleterious sweeps

Parul Johri, Brian Charlesworth, Emma K. Howell, Michael Lynch, Jeffrey D. Jensen
doi: https://doi.org/10.1101/2020.11.16.385666
Parul Johri
1School of Life Sciences, Arizona State University, Tempe, AZ 85287, United States
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Brian Charlesworth
2Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, EH9 3FL, United Kingdom
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Emma K. Howell
1School of Life Sciences, Arizona State University, Tempe, AZ 85287, United States
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Michael Lynch
1School of Life Sciences, Arizona State University, Tempe, AZ 85287, United States
3Center for Mechanisms of Evolution, The Biodesign Institute, Arizona State University, Tempe, AZ, United States
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  • For correspondence: jeffrey.d.jensen@asu.edu
Jeffrey D. Jensen
1School of Life Sciences, Arizona State University, Tempe, AZ 85287, United States
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  • For correspondence: jeffrey.d.jensen@asu.edu
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ABSTRACT

It has previously been shown that, conditional on its fixation, the time to fixation of a semi-dominant deleterious autosomal mutation in a randomly mating population is the same as that of an advantageous mutation. This result implies that deleterious mutations may generate selective sweep effects. Although their fixation probabilities greatly differ, the much larger input of deleterious relative to beneficial mutations suggests that this phenomenon could be important. We here examine how the fixation of mildly deleterious mutations affects levels and patterns of polymorphism at linked sites, and how this class of sites may contribute to divergence between-populations and species. We find that, while deleterious sweeps are unlikely to represent a significant proportion of outliers in polymorphism-based genomic scans within populations, minor shifts in the frequencies of deleterious mutations can influence the proportions of private variants and the value of FST after a recent population split. As sites subject to deleterious mutations are necessarily found in functional genomic regions, interpretations in terms of recurrent positive selection may require reconsideration.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted November 17, 2020.
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Revisiting the notion of deleterious sweeps
Parul Johri, Brian Charlesworth, Emma K. Howell, Michael Lynch, Jeffrey D. Jensen
bioRxiv 2020.11.16.385666; doi: https://doi.org/10.1101/2020.11.16.385666
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Revisiting the notion of deleterious sweeps
Parul Johri, Brian Charlesworth, Emma K. Howell, Michael Lynch, Jeffrey D. Jensen
bioRxiv 2020.11.16.385666; doi: https://doi.org/10.1101/2020.11.16.385666

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