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An assessment of efficacy of Iodine complex (Renessans) against SARS-CoV-2 in non-human primates (Rhesus macaque)

Muhammad Nawaz, Muhammad Asad Ali, Muhammad Adnan Ashraf, Muhammad Zubair Shabbir, Muhammad Abu Bakr Shabbir, Imran Altaf, Sohail Raza, Saira Rafique, Sohail Hassan, Nageen Sardar, Adnan Mehmood, Muhammad Waqar Aziz, Sehar Fazal, Muhammad Tahir Khan, Muhammad Moavia Attique, Ali Asif, Zia Ullah, Mubashir Iqbal, Talha Imtiaz, Muhammad Anwar, Nadia Mukhtar, Tahir Yaqub
doi: https://doi.org/10.1101/2020.11.17.377432
Muhammad Nawaz
1Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan
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Muhammad Asad Ali
1Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan
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Muhammad Adnan Ashraf
1Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan
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Muhammad Zubair Shabbir
1Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan
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Muhammad Abu Bakr Shabbir
1Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan
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Imran Altaf
1Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan
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Sohail Raza
1Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan
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Saira Rafique
1Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan
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Sohail Hassan
1Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan
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Nageen Sardar
1Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan
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Adnan Mehmood
1Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan
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Muhammad Waqar Aziz
1Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan
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Sehar Fazal
1Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan
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Muhammad Tahir Khan
1Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan
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Muhammad Moavia Attique
1Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan
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Ali Asif
1Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan
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Zia Ullah
1Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan
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Mubashir Iqbal
1Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan
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Talha Imtiaz
1Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan
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Muhammad Anwar
1Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan
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Nadia Mukhtar
2Institute of Public Health, Lahore, Pakistan
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Tahir Yaqub
1Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan
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  • For correspondence: tahiryaqub@uvas.edu.pk
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ABSTRACT

Renessans is an iodine complex which has proven in vitro antiviral activity including Anti-SARS-CoV-2 activity. The present study was designed to determine its efficacy against SARS-CoV-2 in monkeys (Rhesus macaque). A total of 14 monkeys were divided into four groups: A) Prophylactic group (n=03), (B) Treatment group (n=03), (C) infection control group (n=04) and (D) negative control group (n=04) and were housed in BSL-3 Animal facility while group D was housed at another animal house. Group A was administered with Renessans @ 2.85 mg/7 kg from 5 days prior to the infection to 08 days post infections (DPI). Group B was administered with Renessans from 03-08 DPI @ 2.85 mg/7 kg. Group C was administered with WIF only. The infection @ 2 × 106 TCID of SARS-CoV-2 was given to all group monkeys through intranasal and oral route under anesthesia. Nasal swab samples (at different times) and fecal matter on daily basis were collected for the detection of SARS-CoV-2 through real-time quantitative PCR. Three monkeys (one from each of group A, B and C) were euthanized at 07 DPI to determine the gross pathological lesions and SARS-CoV-2 detection from internal tissues. Nasal swabs from all the monkeys from group A, B and C were positive for SARS-CoV-2 at 02 and 07 DPI (Day 05 of treatment). At 14 DPI, all (100%) nasal swabs from group A were negative for SARS-CoV-2 while 50% and 100% were positive from group B and C, respectively. At 21 DPI, monkeys from group B were negative and all in group C were still positive for SARS-CoV-2. Similarly, fecal matter of monkeys in group A and B was returned negative in significantly lesser time as compared to monkeys from infection control group. Based on these research findings it is concluded that the Renessans has in-vivo SARS-CoV-2 activity and may result in early clearance of SARS-CoV-2. Therefore, a clinical trial of the drug in COVID-19 patients may reveal its anti-COVID-19 potential.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted November 18, 2020.
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An assessment of efficacy of Iodine complex (Renessans) against SARS-CoV-2 in non-human primates (Rhesus macaque)
Muhammad Nawaz, Muhammad Asad Ali, Muhammad Adnan Ashraf, Muhammad Zubair Shabbir, Muhammad Abu Bakr Shabbir, Imran Altaf, Sohail Raza, Saira Rafique, Sohail Hassan, Nageen Sardar, Adnan Mehmood, Muhammad Waqar Aziz, Sehar Fazal, Muhammad Tahir Khan, Muhammad Moavia Attique, Ali Asif, Zia Ullah, Mubashir Iqbal, Talha Imtiaz, Muhammad Anwar, Nadia Mukhtar, Tahir Yaqub
bioRxiv 2020.11.17.377432; doi: https://doi.org/10.1101/2020.11.17.377432
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An assessment of efficacy of Iodine complex (Renessans) against SARS-CoV-2 in non-human primates (Rhesus macaque)
Muhammad Nawaz, Muhammad Asad Ali, Muhammad Adnan Ashraf, Muhammad Zubair Shabbir, Muhammad Abu Bakr Shabbir, Imran Altaf, Sohail Raza, Saira Rafique, Sohail Hassan, Nageen Sardar, Adnan Mehmood, Muhammad Waqar Aziz, Sehar Fazal, Muhammad Tahir Khan, Muhammad Moavia Attique, Ali Asif, Zia Ullah, Mubashir Iqbal, Talha Imtiaz, Muhammad Anwar, Nadia Mukhtar, Tahir Yaqub
bioRxiv 2020.11.17.377432; doi: https://doi.org/10.1101/2020.11.17.377432

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