Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Revealing interspecies transmission barriers of avian influenza A viruses

Mahmoud M. Naguib, Per Eriksson, Elinor Jax, Jonas Nilsson, Carina Sihlbom, Cecilia Lindskog, Caroline Bröjer, Britt-Marie Olsson, Michelle Wille, Jonas Waldenström, Göran Larson, Robert H. S. Kraus, Åke Lundkvist, Björn Olsen, Josef D. Järhult, Patrik Ellström
doi: https://doi.org/10.1101/2020.11.17.386755
Mahmoud M. Naguib
1Zoonosis Science Center, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala SE-75237, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Per Eriksson
1Zoonosis Science Center, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala SE-75237, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Elinor Jax
2Department of Migration, Max Planck Institute of Animal Behavior, Radolfzell 78315, Germany
3Department of Biology, University of Konstanz, Konstanz 78457, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jonas Nilsson
4Department of Laboratory Medicine, University of Gothenburg, SE-413 45, Gothenburg, Sweden
5Laboratory of Clinical Chemistry, Sahlgrenska University Hospital, SE-413 45, Gothenburg, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Carina Sihlbom
6Proteomics Core Facility, University of Gothenburg, Sahlgrenska Academy, SE-405 30, Gothenburg, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Cecilia Lindskog
7Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, SE-75185, Uppsala, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Caroline Bröjer
8Department of Pathology and Wildlife Diseases, National Veterinary Institute (SVA), SE-75189 Uppsala, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Britt-Marie Olsson
6Proteomics Core Facility, University of Gothenburg, Sahlgrenska Academy, SE-405 30, Gothenburg, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michelle Wille
1Zoonosis Science Center, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala SE-75237, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jonas Waldenström
9Centre for Ecology and Evolution in Microbial Model Systems, Linnaeus University, SE-391 82 Kalmar, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Göran Larson
4Department of Laboratory Medicine, University of Gothenburg, SE-413 45, Gothenburg, Sweden
5Laboratory of Clinical Chemistry, Sahlgrenska University Hospital, SE-413 45, Gothenburg, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Robert H. S. Kraus
2Department of Migration, Max Planck Institute of Animal Behavior, Radolfzell 78315, Germany
3Department of Biology, University of Konstanz, Konstanz 78457, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Åke Lundkvist
1Zoonosis Science Center, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala SE-75237, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Björn Olsen
10Zoonosis Science Center, Department of Medical Sciences, Uppsala University, Uppsala SE-75185, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Josef D. Järhult
10Zoonosis Science Center, Department of Medical Sciences, Uppsala University, Uppsala SE-75185, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Patrik Ellström
10Zoonosis Science Center, Department of Medical Sciences, Uppsala University, Uppsala SE-75185, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: patrik.ellstrom@medsci.uu.se
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Influenza A virus (IAV) pandemics result from interspecies transmission events within the avian reservoir and further to mammals including humans. Investigating molecular virus–host interactions dictating this process and the adaptations to the new hosts that follow is vital to understand zoonotic IAV spread. Receptor incompatibility has been suggested to limit zoonotic IAV transmission from the wild bird reservoir. Other barriers to interspecies transmission, particularly within the avian system, largely remain elusive. Through assessment of infection dynamics of mallard origin IAV in two different avian hosts, coupled with studies of receptor expression and host response we aimed to reveal the host-pathogen interactions in a cross-species transmission event. We found that shedding patterns and innate immune responses were highly dependent on viral genotypes, host species and inoculation routes, but less dependent on receptor expression. Further, in contrary to the prevailing dogma we demonstrate that birds can produce a wide range of different sialylated structures also found in mammals, e.g. extended N- and O-linked Neu5Acα2,6 terminated glycans. Overall, receptor incompatibility is not the sole transmission barrier for IAV between birds and to humans, but other host-pathogen factors deserve dedicated studies to achieve proper pandemic preparedness.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted November 17, 2020.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Revealing interspecies transmission barriers of avian influenza A viruses
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Revealing interspecies transmission barriers of avian influenza A viruses
Mahmoud M. Naguib, Per Eriksson, Elinor Jax, Jonas Nilsson, Carina Sihlbom, Cecilia Lindskog, Caroline Bröjer, Britt-Marie Olsson, Michelle Wille, Jonas Waldenström, Göran Larson, Robert H. S. Kraus, Åke Lundkvist, Björn Olsen, Josef D. Järhult, Patrik Ellström
bioRxiv 2020.11.17.386755; doi: https://doi.org/10.1101/2020.11.17.386755
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
Revealing interspecies transmission barriers of avian influenza A viruses
Mahmoud M. Naguib, Per Eriksson, Elinor Jax, Jonas Nilsson, Carina Sihlbom, Cecilia Lindskog, Caroline Bröjer, Britt-Marie Olsson, Michelle Wille, Jonas Waldenström, Göran Larson, Robert H. S. Kraus, Åke Lundkvist, Björn Olsen, Josef D. Järhult, Patrik Ellström
bioRxiv 2020.11.17.386755; doi: https://doi.org/10.1101/2020.11.17.386755

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Microbiology
Subject Areas
All Articles
  • Animal Behavior and Cognition (2440)
  • Biochemistry (4803)
  • Bioengineering (3340)
  • Bioinformatics (14724)
  • Biophysics (6658)
  • Cancer Biology (5188)
  • Cell Biology (7455)
  • Clinical Trials (138)
  • Developmental Biology (4378)
  • Ecology (6904)
  • Epidemiology (2057)
  • Evolutionary Biology (9943)
  • Genetics (7357)
  • Genomics (9550)
  • Immunology (4583)
  • Microbiology (12730)
  • Molecular Biology (4960)
  • Neuroscience (28422)
  • Paleontology (199)
  • Pathology (810)
  • Pharmacology and Toxicology (1400)
  • Physiology (2031)
  • Plant Biology (4521)
  • Scientific Communication and Education (980)
  • Synthetic Biology (1305)
  • Systems Biology (3922)
  • Zoology (731)