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Universally available herbal teas based on sage and perilla elicit potent antiviral activity against SARS-CoV-2 in vitro

View ORCID ProfileVu Thuy Khanh Le-Trilling, Denise Mennerich, Corinna Schuler, Yulia Flores-Martinez, Benjamin Katschinski, Ulf Dittmer, View ORCID ProfileMirko Trilling
doi: https://doi.org/10.1101/2020.11.18.388710
Vu Thuy Khanh Le-Trilling
1Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
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  • ORCID record for Vu Thuy Khanh Le-Trilling
  • For correspondence: Khanh.Le@uk-essen.de Mirko.Trilling@uk-essen.de
Denise Mennerich
1Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
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Corinna Schuler
1Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
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Yulia Flores-Martinez
1Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
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Benjamin Katschinski
1Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
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Ulf Dittmer
1Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
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Mirko Trilling
1Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
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  • ORCID record for Mirko Trilling
  • For correspondence: Khanh.Le@uk-essen.de Mirko.Trilling@uk-essen.de
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Abstract

The current SARS-CoV-2/COVID-19 pandemic represents an unprecedented medical and socioeconomic crisis. Highly efficient treatment options preventing morbidity and mortality are not broadly available and approved drugs are hardly affordable in developing countries. Even after vaccine approvals, it will take several months until the vaccinated and convalescent individuals establish herd immunity. Meanwhile, non-pharmaceutical interventions and antiviral treatments are indispensable to curb the death toll of the pandemic. To identify cost-effective and ubiquitously available options, we tested common herbs consumed worldwide as herbal teas. We found that aqueous infusions prepared by boiling leaves of the Lamiaceae plants perilla and sage elicit potent antiviral activity against SARS-CoV-2 in human cells. Sustained antiviral activity was evident even when cells were treated for only half an hour, and in therapeutic as well as prophylactic regimens. Given the urgency, such inexpensive and broadly available substances might provide help during the pandemic - especially in low-income regions.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Lead contact: Mirko Trilling: Mirko.Trilling{at}uk-essen.de, Mailing address: University Hospital Essen, University of Duisburg-Essen, Institute for Virology, Virchowstr. 179, 45147 Essen, Germany

  • Unfortunately, the order of figure 3 and figure 4 was swapped during the first upload. This has been corrected in the revised version.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted November 22, 2020.
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Universally available herbal teas based on sage and perilla elicit potent antiviral activity against SARS-CoV-2 in vitro
Vu Thuy Khanh Le-Trilling, Denise Mennerich, Corinna Schuler, Yulia Flores-Martinez, Benjamin Katschinski, Ulf Dittmer, Mirko Trilling
bioRxiv 2020.11.18.388710; doi: https://doi.org/10.1101/2020.11.18.388710
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Universally available herbal teas based on sage and perilla elicit potent antiviral activity against SARS-CoV-2 in vitro
Vu Thuy Khanh Le-Trilling, Denise Mennerich, Corinna Schuler, Yulia Flores-Martinez, Benjamin Katschinski, Ulf Dittmer, Mirko Trilling
bioRxiv 2020.11.18.388710; doi: https://doi.org/10.1101/2020.11.18.388710

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