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HLA class I genotypes customize vaccination strategies in immune simulation to combat COVID-19

View ORCID ProfileShouxiong Huang, Ming Tan
doi: https://doi.org/10.1101/2020.11.18.388983
Shouxiong Huang
1Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH 45249, USA
2Immunology Graduate Program, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA
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  • For correspondence: Shouxiong.huang@uc.edu
Ming Tan
3Division of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA
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Abstract

Memory CD8+ T cells are associated with a better outcome in Coronavirus Disease 2019 (COVID-19) and recognized as promising vaccine targets against viral infections. This study determined the efficacy of population-dominant and infection-relevant human leukocyte antigens (HLA) class I proteins to present severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) peptides through calculating binding affinities and simulating CD8+ T cell responses. As a result, HLA class I proteins distinguished or shared various viral peptides derived from viruses. HLA class I supertypes clustered viral peptides through recognizing anchor and preferred residues. SARS-CoV-2 peptides overlapped significantly with SARS but minimally with common human coronaviruses. Immune simulation of CD8+ T cell activation using predicted SARS-CoV-2 peptide antigens depended on high-affinity peptide binding, anchor residue interaction, and synergistic presentation of HLA class I proteins in individuals. Results demonstrated that multi-epitope vaccination, employing a strong binding affinity, viral adjuvants, and heterozygous HLA class I genes, induced potent immune responses. Therefore, optimal CD8+ T cell responses can be achieved and customized contingent on HLA class I genotypes in human populations, supporting a precise vaccination strategy to combat COVID-19.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted November 18, 2020.
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HLA class I genotypes customize vaccination strategies in immune simulation to combat COVID-19
Shouxiong Huang, Ming Tan
bioRxiv 2020.11.18.388983; doi: https://doi.org/10.1101/2020.11.18.388983
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HLA class I genotypes customize vaccination strategies in immune simulation to combat COVID-19
Shouxiong Huang, Ming Tan
bioRxiv 2020.11.18.388983; doi: https://doi.org/10.1101/2020.11.18.388983

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