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Aberrant gliogenesis and excitation in MEF2C autism patient hiPSC-neurons and cerebral organoids
Dorit Trudler, Swagata Ghatak, James Parker, Maria Talantova, Titas Grabauskas, Sarah Moore Noveral, Mayu Teranaka, Melissa Luevanos, Nima Dolatabadi, Clare Bakker, Kevin Lopez, Abdullah Sultan, View ORCID ProfileAgnes Chan, Yongwook Choi, Riki Kawaguchi, Nicholas Schork, Pawel Stankiewicz, Ivan Garcia-Bassets, Piotr Kozbial, Michael G. Rosenfeld, Nobuki Nakanishi, Daniel H. Geschwind, Shing Fai Chan, Rajesh Ambasudhan, Stuart A. Lipton
doi: https://doi.org/10.1101/2020.11.19.387639
Dorit Trudler
1Neuroscience Translational Center and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
Swagata Ghatak
1Neuroscience Translational Center and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
James Parker
2Neurodegenerative Disease Center, Scintillon Institute, San Diego, California 92121, USA
Maria Talantova
1Neuroscience Translational Center and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
Titas Grabauskas
1Neuroscience Translational Center and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
Sarah Moore Noveral
2Neurodegenerative Disease Center, Scintillon Institute, San Diego, California 92121, USA
Mayu Teranaka
2Neurodegenerative Disease Center, Scintillon Institute, San Diego, California 92121, USA
Melissa Luevanos
1Neuroscience Translational Center and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
Nima Dolatabadi
1Neuroscience Translational Center and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
Clare Bakker
1Neuroscience Translational Center and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
Kevin Lopez
2Neurodegenerative Disease Center, Scintillon Institute, San Diego, California 92121, USA
Abdullah Sultan
2Neurodegenerative Disease Center, Scintillon Institute, San Diego, California 92121, USA
Agnes Chan
3Translational Genomics Research Institute, Phoenix, Arizona 85004, USA
Yongwook Choi
3Translational Genomics Research Institute, Phoenix, Arizona 85004, USA
Riki Kawaguchi
4Departments of Psychiatry and Neurology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
Nicholas Schork
3Translational Genomics Research Institute, Phoenix, Arizona 85004, USA
5Departments of Psychiatry and Family Medicine and Public Health, University of California, San Diego, La Jolla, California 92037, USA
Pawel Stankiewicz
6Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Ivan Garcia-Bassets
7Howard Hughes Medical Institute, School and Department of Medicine, University of California, San Diego School of Medicine, La Jolla, California 92093, USA
Piotr Kozbial
7Howard Hughes Medical Institute, School and Department of Medicine, University of California, San Diego School of Medicine, La Jolla, California 92093, USA
Michael G. Rosenfeld
7Howard Hughes Medical Institute, School and Department of Medicine, University of California, San Diego School of Medicine, La Jolla, California 92093, USA
Nobuki Nakanishi
2Neurodegenerative Disease Center, Scintillon Institute, San Diego, California 92121, USA
Daniel H. Geschwind
8Department of Neurology, Center for Autism Research and Treatment; Program in Neurobehavioral Genetics; Department of Human Genetics; Department of Psychiatry, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
Shing Fai Chan
9Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, USA
Rajesh Ambasudhan
1Neuroscience Translational Center and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
2Neurodegenerative Disease Center, Scintillon Institute, San Diego, California 92121, USA
Stuart A. Lipton
1Neuroscience Translational Center and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
2Neurodegenerative Disease Center, Scintillon Institute, San Diego, California 92121, USA
10Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, California 92093, USA
Article usage
Posted November 19, 2020.
Aberrant gliogenesis and excitation in MEF2C autism patient hiPSC-neurons and cerebral organoids
Dorit Trudler, Swagata Ghatak, James Parker, Maria Talantova, Titas Grabauskas, Sarah Moore Noveral, Mayu Teranaka, Melissa Luevanos, Nima Dolatabadi, Clare Bakker, Kevin Lopez, Abdullah Sultan, Agnes Chan, Yongwook Choi, Riki Kawaguchi, Nicholas Schork, Pawel Stankiewicz, Ivan Garcia-Bassets, Piotr Kozbial, Michael G. Rosenfeld, Nobuki Nakanishi, Daniel H. Geschwind, Shing Fai Chan, Rajesh Ambasudhan, Stuart A. Lipton
bioRxiv 2020.11.19.387639; doi: https://doi.org/10.1101/2020.11.19.387639
Aberrant gliogenesis and excitation in MEF2C autism patient hiPSC-neurons and cerebral organoids
Dorit Trudler, Swagata Ghatak, James Parker, Maria Talantova, Titas Grabauskas, Sarah Moore Noveral, Mayu Teranaka, Melissa Luevanos, Nima Dolatabadi, Clare Bakker, Kevin Lopez, Abdullah Sultan, Agnes Chan, Yongwook Choi, Riki Kawaguchi, Nicholas Schork, Pawel Stankiewicz, Ivan Garcia-Bassets, Piotr Kozbial, Michael G. Rosenfeld, Nobuki Nakanishi, Daniel H. Geschwind, Shing Fai Chan, Rajesh Ambasudhan, Stuart A. Lipton
bioRxiv 2020.11.19.387639; doi: https://doi.org/10.1101/2020.11.19.387639
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