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Unscheduled origin building in S-phase upon tight CDK1 inhibition suppresses CFS instability

Olivier Brison, View ORCID ProfileStefano Gnan, Dana Azar, Mélanie Schmidt, Stéphane Koundrioukoff, Sami El-Hilali, Yan Jaszczyszyn, Anne-Marie Lachages, Claude Thermes, View ORCID ProfileChun-Long Chen, View ORCID ProfileMichelle Debatisse
doi: https://doi.org/10.1101/2020.11.19.390054
Olivier Brison
1CNRS UMR 9019, Gustave Roussy Institute, F-94805, Villejuif, France
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Stefano Gnan
2Curie Institute, PSL Research University, CNRS UMR 3244, F-75005, Paris, France
3Sorbonne University, F-75005 Paris, France
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  • ORCID record for Stefano Gnan
Dana Azar
2Curie Institute, PSL Research University, CNRS UMR 3244, F-75005, Paris, France
6Laboratoire Biodiversité et Génomique Fonctionnelle, Faculté des Sciences, Université Saint-Joseph, 1107 2050 Beirut, Lebanon
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Mélanie Schmidt
1CNRS UMR 9019, Gustave Roussy Institute, F-94805, Villejuif, France
5Paris-Saclay University, F-91198, Gif-sur-Yvette, France
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Stéphane Koundrioukoff
1CNRS UMR 9019, Gustave Roussy Institute, F-94805, Villejuif, France
3Sorbonne University, F-75005 Paris, France
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Sami El-Hilali
2Curie Institute, PSL Research University, CNRS UMR 3244, F-75005, Paris, France
3Sorbonne University, F-75005 Paris, France
7Villefranche sur mer Developmental Biology Laboratory, CNRS UMR7009, F-06234 Villefranche-sur-Mer, France
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Yan Jaszczyszyn
4Institute for Integrative Biology of the Cell (I2BC), UMR 9198CNRS, CEA, Paris-Sud University, F-91198, Gif-sur-Yvette, France
5Paris-Saclay University, F-91198, Gif-sur-Yvette, France
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Anne-Marie Lachages
2Curie Institute, PSL Research University, CNRS UMR 3244, F-75005, Paris, France
8UTCBS, CNRS UMR 8258/ INSERM U 1267, Sorbonne-Paris-Cité University, F-75006 Paris, France
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Claude Thermes
4Institute for Integrative Biology of the Cell (I2BC), UMR 9198CNRS, CEA, Paris-Sud University, F-91198, Gif-sur-Yvette, France
5Paris-Saclay University, F-91198, Gif-sur-Yvette, France
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Chun-Long Chen
2Curie Institute, PSL Research University, CNRS UMR 3244, F-75005, Paris, France
3Sorbonne University, F-75005 Paris, France
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  • ORCID record for Chun-Long Chen
Michelle Debatisse
1CNRS UMR 9019, Gustave Roussy Institute, F-94805, Villejuif, France
3Sorbonne University, F-75005 Paris, France
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  • ORCID record for Michelle Debatisse
  • For correspondence: michelle.debatisse@gustaveroussy.fr
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Article Information

doi 
https://doi.org/10.1101/2020.11.19.390054
History 
  • November 20, 2020.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Olivier Brison1,**,
  2. Stefano Gnan2,3,**,
  3. Dana Azar2,6,**,
  4. Mélanie Schmidt1,5,
  5. Stéphane Koundrioukoff1,3,
  6. Sami El-Hilali2,3,7,
  7. Yan Jaszczyszyn4,5,
  8. Anne-Marie Lachages2,8,
  9. Claude Thermes4,5,
  10. Chun-Long Chen2,3 and
  11. Michelle Debatisse1,3,+
  1. 1CNRS UMR 9019, Gustave Roussy Institute, F-94805, Villejuif, France
  2. 2Curie Institute, PSL Research University, CNRS UMR 3244, F-75005, Paris, France
  3. 3Sorbonne University, F-75005 Paris, France
  4. 4Institute for Integrative Biology of the Cell (I2BC), UMR 9198CNRS, CEA, Paris-Sud University, F-91198, Gif-sur-Yvette, France
  5. 5Paris-Saclay University, F-91198, Gif-sur-Yvette, France
  6. 6Laboratoire Biodiversité et Génomique Fonctionnelle, Faculté des Sciences, Université Saint-Joseph, 1107 2050 Beirut, Lebanon
  7. 7Villefranche sur mer Developmental Biology Laboratory, CNRS UMR7009, F-06234 Villefranche-sur-Mer, France
  8. 8UTCBS, CNRS UMR 8258/ INSERM U 1267, Sorbonne-Paris-Cité University, F-75006 Paris, France
  1. ↵+Corresponding author, M. Debatisse: Gustave Roussy Institute, Research Department, CNRS UMR 9019, F-94805, Villejuif, France, Tel: +33-(0)1 42 11 48 24, Email: michelle.debatisse{at}gustaveroussy.fr
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Unscheduled origin building in S-phase upon tight CDK1 inhibition suppresses CFS instability
Olivier Brison, Stefano Gnan, Dana Azar, Mélanie Schmidt, Stéphane Koundrioukoff, Sami El-Hilali, Yan Jaszczyszyn, Anne-Marie Lachages, Claude Thermes, Chun-Long Chen, Michelle Debatisse
bioRxiv 2020.11.19.390054; doi: https://doi.org/10.1101/2020.11.19.390054
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Unscheduled origin building in S-phase upon tight CDK1 inhibition suppresses CFS instability
Olivier Brison, Stefano Gnan, Dana Azar, Mélanie Schmidt, Stéphane Koundrioukoff, Sami El-Hilali, Yan Jaszczyszyn, Anne-Marie Lachages, Claude Thermes, Chun-Long Chen, Michelle Debatisse
bioRxiv 2020.11.19.390054; doi: https://doi.org/10.1101/2020.11.19.390054

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