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History
- November 21, 2020.
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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Author Information
- Jacqueline M. Tokarew1,2,*,
- Daniel N. El-Kodsi1,2,*,
- Nathalie A. Lengacher1,2,
- Travis K. Fehr1,2,
- Angela P. Nguyen1,
- Bojan Shutinoski1,
- Brian O’Nuallain3,
- Ming Jin3,
- Jasmine M. Khan1,
- Andy C. H. Ng1,
- Juan Li1,
- Qiubo Jiang1,
- Mei Zhang4,
- Liqun Wang3,
- Rajib Sengupta5,5*,
- Kathryn R. Barber6,
- An Tran6,
- Stephanie Zandee7,
- Xiajun Dong8,
- Clemens R. Scherzer8,
- Alexandre Prat7,
- Eve Tsai1,9,
- Masashi Takanashi10,
- Nobutaka Hattori10,
- Jennifer A. Chan11,
- Luigi Zecca12,
- Andrew B. West13,
- Arne Holmgren5,%,
- Lawrence Puente14,
- Gary S. Shaw6,
- Gergely Toth15,
- John M. Woulfe1,4,
- Peggy Taylor3,
- Julianna J. Tomlinson1,16,# and
- Michael G. Schlossmacher1,16,17,#,*
- 1Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada
- 2Graduate Program in Cellular and Molecular Medicine (Neuroscience), Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada
- 3BioLegend Inc., Dedham, MA., USA
- 4Department of Pathology and Laboratory Medicine, The Ottawa Hospital, Ottawa, ON, Canada
- 5Department of Biochemistry, Karolinska Institute, Stockholm, Sweden
- 5*Present Address: Amity Institute of Biotechnology, Amity University, Kolkata, West Bengal 700135, India
- 6Department of Biochemistry, University of Western Ontario, London, ON, Canada
- 7Department of Neuroscience, Faculty of Medicine, University of Montreal, Montreal, QC, Canada
- 8Ann Romney Center for Neurologic Diseases, Brigham & Women’s Hospital, Boston, MA, USA
- 9Division of Neurosurgery, Department of Surgery, The Ottawa Hospital, Ottawa, ON, Canada
- 10Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
- 11Department of Pathology & Laboratory Medicine, University of Calgary, Calgary, AB, Canada
- 12Institute of Biomedical Technologies, Italian National Research Council, Segrate (Milano), Italy
- 13Departments of Neurobiology and Pharmacology & Cancer Biology, Duke University, Durham, NC, USA
- 14Proteomics Core Facility, Ottawa Hospital Research Institute, Ottawa, ON, Canada
- 15Institute of Organic Chemistry, Research Center for Natural Sciences, Budapest, Hungary
- 16University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada
- 17Division of Neurology, Department of Medicine, The Ottawa Hospital, Ottawa, ON, Canada
- ↵* Corresponding author; email: mschlossmacher{at}ohri.ca
↵* these authors contributed equally to this work
Posted November 21, 2020.
Age-Associated Insolubility of Parkin in Human Midbrain is Linked to Redox Balance and Sequestration of Reactive Dopamine Metabolites
