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Age-Associated Insolubility of Parkin in Human Midbrain is Linked to Redox Balance and Sequestration of Reactive Dopamine Metabolites
Jacqueline M. Tokarew, View ORCID ProfileDaniel N. El-Kodsi, Nathalie A. Lengacher, Travis K. Fehr, Angela P. Nguyen, Bojan Shutinoski, Brian O’Nuallain, Ming Jin, Jasmine M. Khan, Andy C. H. Ng, Juan Li, Qiubo Jiang, Mei Zhang, Liqun Wang, Rajib Sengupta, Kathryn R. Barber, An Tran, Stephanie Zandee, View ORCID ProfileXiajun Dong, Clemens R. Scherzer, Alexandre Prat, Eve Tsai, Masashi Takanashi, Nobutaka Hattori, Jennifer A. Chan, Luigi Zecca, View ORCID ProfileAndrew B. West, Arne Holmgren, Lawrence Puente, Gary S. Shaw, Gergely Toth, John M. Woulfe, Peggy Taylor, View ORCID ProfileJulianna J. Tomlinson, Michael G. Schlossmacher
doi: https://doi.org/10.1101/2020.11.20.392175
Jacqueline M. Tokarew
1Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada
2Graduate Program in Cellular and Molecular Medicine (Neuroscience), Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada
Daniel N. El-Kodsi
1Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada
2Graduate Program in Cellular and Molecular Medicine (Neuroscience), Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada
Nathalie A. Lengacher
1Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada
2Graduate Program in Cellular and Molecular Medicine (Neuroscience), Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada
Travis K. Fehr
1Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada
2Graduate Program in Cellular and Molecular Medicine (Neuroscience), Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada
Angela P. Nguyen
1Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada
Bojan Shutinoski
1Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada
Brian O’Nuallain
3BioLegend Inc., Dedham, MA., USA
Ming Jin
3BioLegend Inc., Dedham, MA., USA
Jasmine M. Khan
1Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada
Andy C. H. Ng
1Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada
Juan Li
1Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada
Qiubo Jiang
1Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada
Mei Zhang
4Department of Pathology and Laboratory Medicine, The Ottawa Hospital, Ottawa, ON, Canada
Liqun Wang
3BioLegend Inc., Dedham, MA., USA
Rajib Sengupta
5Department of Biochemistry, Karolinska Institute, Stockholm, Sweden
5*Present Address: Amity Institute of Biotechnology, Amity University, Kolkata, West Bengal 700135, India
Kathryn R. Barber
6Department of Biochemistry, University of Western Ontario, London, ON, Canada
An Tran
6Department of Biochemistry, University of Western Ontario, London, ON, Canada
Stephanie Zandee
7Department of Neuroscience, Faculty of Medicine, University of Montreal, Montreal, QC, Canada
Xiajun Dong
8Ann Romney Center for Neurologic Diseases, Brigham & Women’s Hospital, Boston, MA, USA
Clemens R. Scherzer
8Ann Romney Center for Neurologic Diseases, Brigham & Women’s Hospital, Boston, MA, USA
Alexandre Prat
7Department of Neuroscience, Faculty of Medicine, University of Montreal, Montreal, QC, Canada
Eve Tsai
1Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada
9Division of Neurosurgery, Department of Surgery, The Ottawa Hospital, Ottawa, ON, Canada
Masashi Takanashi
10Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
Nobutaka Hattori
10Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
Jennifer A. Chan
11Department of Pathology & Laboratory Medicine, University of Calgary, Calgary, AB, Canada
Luigi Zecca
12Institute of Biomedical Technologies, Italian National Research Council, Segrate (Milano), Italy
Andrew B. West
13Departments of Neurobiology and Pharmacology & Cancer Biology, Duke University, Durham, NC, USA
Arne Holmgren
5Department of Biochemistry, Karolinska Institute, Stockholm, Sweden
Lawrence Puente
14Proteomics Core Facility, Ottawa Hospital Research Institute, Ottawa, ON, Canada
Gary S. Shaw
6Department of Biochemistry, University of Western Ontario, London, ON, Canada
Gergely Toth
15Institute of Organic Chemistry, Research Center for Natural Sciences, Budapest, Hungary
John M. Woulfe
1Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada
4Department of Pathology and Laboratory Medicine, The Ottawa Hospital, Ottawa, ON, Canada
Peggy Taylor
3BioLegend Inc., Dedham, MA., USA
Julianna J. Tomlinson
1Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada
16University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada
Michael G. Schlossmacher
1Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada
16University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada
17Division of Neurology, Department of Medicine, The Ottawa Hospital, Ottawa, ON, Canada
Article usage
Posted November 21, 2020.
Age-Associated Insolubility of Parkin in Human Midbrain is Linked to Redox Balance and Sequestration of Reactive Dopamine Metabolites
Jacqueline M. Tokarew, Daniel N. El-Kodsi, Nathalie A. Lengacher, Travis K. Fehr, Angela P. Nguyen, Bojan Shutinoski, Brian O’Nuallain, Ming Jin, Jasmine M. Khan, Andy C. H. Ng, Juan Li, Qiubo Jiang, Mei Zhang, Liqun Wang, Rajib Sengupta, Kathryn R. Barber, An Tran, Stephanie Zandee, Xiajun Dong, Clemens R. Scherzer, Alexandre Prat, Eve Tsai, Masashi Takanashi, Nobutaka Hattori, Jennifer A. Chan, Luigi Zecca, Andrew B. West, Arne Holmgren, Lawrence Puente, Gary S. Shaw, Gergely Toth, John M. Woulfe, Peggy Taylor, Julianna J. Tomlinson, Michael G. Schlossmacher
bioRxiv 2020.11.20.392175; doi: https://doi.org/10.1101/2020.11.20.392175
Age-Associated Insolubility of Parkin in Human Midbrain is Linked to Redox Balance and Sequestration of Reactive Dopamine Metabolites
Jacqueline M. Tokarew, Daniel N. El-Kodsi, Nathalie A. Lengacher, Travis K. Fehr, Angela P. Nguyen, Bojan Shutinoski, Brian O’Nuallain, Ming Jin, Jasmine M. Khan, Andy C. H. Ng, Juan Li, Qiubo Jiang, Mei Zhang, Liqun Wang, Rajib Sengupta, Kathryn R. Barber, An Tran, Stephanie Zandee, Xiajun Dong, Clemens R. Scherzer, Alexandre Prat, Eve Tsai, Masashi Takanashi, Nobutaka Hattori, Jennifer A. Chan, Luigi Zecca, Andrew B. West, Arne Holmgren, Lawrence Puente, Gary S. Shaw, Gergely Toth, John M. Woulfe, Peggy Taylor, Julianna J. Tomlinson, Michael G. Schlossmacher
bioRxiv 2020.11.20.392175; doi: https://doi.org/10.1101/2020.11.20.392175
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