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A repurposed, blood gene signature is associated with poor outcomes in SARS-CoV-2

Brenda M. Juan-Guardela, Jiehuan Sun, Tong Zhang, Bing Xu, Gaetane Michaud, Jose D. Herazo-Maya
doi: https://doi.org/10.1101/2020.11.21.392670
Brenda M. Juan-Guardela
1NCH Healthcare System, Naples, Fl, USA
2Division of Pulmonary and Critical Care Medicine, University of South Florida, Tampa, Fl, USA
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Jiehuan Sun
3Division of Epidemiology and Biostatistics, University of Illinois at Chicago, Chicago, Il, USA
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Tong Zhang
3Division of Epidemiology and Biostatistics, University of Illinois at Chicago, Chicago, Il, USA
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Bing Xu
3Division of Epidemiology and Biostatistics, University of Illinois at Chicago, Chicago, Il, USA
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Gaetane Michaud
2Division of Pulmonary and Critical Care Medicine, University of South Florida, Tampa, Fl, USA
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Jose D. Herazo-Maya
1NCH Healthcare System, Naples, Fl, USA
2Division of Pulmonary and Critical Care Medicine, University of South Florida, Tampa, Fl, USA
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  • For correspondence: josedavidh@hotmail.com
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Abstract

Poor outcomes after SARS-CoV-2 infection are difficult to predict. Survivors may develop pulmonary fibrosis. We previously identified a 52-gene signature in peripheral blood, predictive of mortality in Idiopathic Pulmonary Fibrosis. In this study, we analyzed this signature in SARS-CoV-2 infected individuals and identified genomic risk profiles with significant differences in outcomes. Analysis of single cell expression data shows that monocytes, red blood cells, neutrophils and dendritic cells are the cellular source of the high risk gene signature.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted November 23, 2020.
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A repurposed, blood gene signature is associated with poor outcomes in SARS-CoV-2
Brenda M. Juan-Guardela, Jiehuan Sun, Tong Zhang, Bing Xu, Gaetane Michaud, Jose D. Herazo-Maya
bioRxiv 2020.11.21.392670; doi: https://doi.org/10.1101/2020.11.21.392670
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A repurposed, blood gene signature is associated with poor outcomes in SARS-CoV-2
Brenda M. Juan-Guardela, Jiehuan Sun, Tong Zhang, Bing Xu, Gaetane Michaud, Jose D. Herazo-Maya
bioRxiv 2020.11.21.392670; doi: https://doi.org/10.1101/2020.11.21.392670

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