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Stable neutralizing antibody levels six months after mild and severe COVID-19 episode

View ORCID ProfileEdwards Pradenas, Benjamin Trinité, Víctor Urrea, Silvia Marfil, Carlos Ávila-Nieto, María Luisa Rodríguez de la Concepción, Ferran Tarrés-Freixas, Silvia Pérez-Yanes, Carla Rovirosa, Erola Ainsua-Enrich, Jordi Rodon, Júlia Vergara-Alert, Joaquim Segalés, Victor Guallar, Alfonso Valencia, Nuria Izquierdo-Useros, Roger Paredes, Lourdes Mateu, Anna Chamorro, Marta Massanella, Jorge Carrillo, Bonaventura Clotet, View ORCID ProfileJulià Blanco
doi: https://doi.org/10.1101/2020.11.22.389056
Edwards Pradenas
1IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916, Badalona, Catalonia, Spain
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  • ORCID record for Edwards Pradenas
Benjamin Trinité
1IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916, Badalona, Catalonia, Spain
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Víctor Urrea
1IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916, Badalona, Catalonia, Spain
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Silvia Marfil
1IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916, Badalona, Catalonia, Spain
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Carlos Ávila-Nieto
1IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916, Badalona, Catalonia, Spain
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María Luisa Rodríguez de la Concepción
1IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916, Badalona, Catalonia, Spain
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Ferran Tarrés-Freixas
1IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916, Badalona, Catalonia, Spain
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Silvia Pérez-Yanes
1IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916, Badalona, Catalonia, Spain
2Laboratorio de Inmunología Celular y Viral, Unidad de Farmacología, Sección de Medicina, Facultad de Ciencias de la Salud, Universidad de La Laguna (ULL), La Laguna, 38071, Tenerife, Spain.
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Carla Rovirosa
1IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916, Badalona, Catalonia, Spain
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Erola Ainsua-Enrich
1IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916, Badalona, Catalonia, Spain
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Jordi Rodon
3IRTA Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la UAB, 08193, Bellaterra, Catalonia, Spain
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Júlia Vergara-Alert
3IRTA Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la UAB, 08193, Bellaterra, Catalonia, Spain
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Joaquim Segalés
4UAB, Centre de Recerca en Sanitat Animal (IRTA-UAB), Campus de la UAB, 08193, Bellaterra, Catalonia, Spain
5Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, UAB, 08193, Bellaterra, Catalonia, Spain
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Victor Guallar
6Barcelona Supercomputing Center, 08034, Barcelona, Catalonia, Spain
7Catalan Institution for Research and Advanced Studies (ICREA), 08010, Barcelona, Catalonia, Spain
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Alfonso Valencia
6Barcelona Supercomputing Center, 08034, Barcelona, Catalonia, Spain
7Catalan Institution for Research and Advanced Studies (ICREA), 08010, Barcelona, Catalonia, Spain
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Nuria Izquierdo-Useros
1IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916, Badalona, Catalonia, Spain
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Roger Paredes
1IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916, Badalona, Catalonia, Spain
8Infectious Diseases Department, Fight against AIDS Foundation (FLS), Germans Trias i Pujol Hospital, 08916, Badalona, Catalonia, Spain
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Lourdes Mateu
8Infectious Diseases Department, Fight against AIDS Foundation (FLS), Germans Trias i Pujol Hospital, 08916, Badalona, Catalonia, Spain
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Anna Chamorro
8Infectious Diseases Department, Fight against AIDS Foundation (FLS), Germans Trias i Pujol Hospital, 08916, Badalona, Catalonia, Spain
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Marta Massanella
1IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916, Badalona, Catalonia, Spain
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Jorge Carrillo
1IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916, Badalona, Catalonia, Spain
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Bonaventura Clotet
1IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916, Badalona, Catalonia, Spain
8Infectious Diseases Department, Fight against AIDS Foundation (FLS), Germans Trias i Pujol Hospital, 08916, Badalona, Catalonia, Spain
9University of Vic–Central University of Catalonia (UVic-UCC), 08500, Vic, Catalonia, Spain
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Julià Blanco
1IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916, Badalona, Catalonia, Spain
9University of Vic–Central University of Catalonia (UVic-UCC), 08500, Vic, Catalonia, Spain
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  • ORCID record for Julià Blanco
  • For correspondence: jblanco@irsicaixa.es
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Abstract

Understanding mid-term kinetics of immunity to SARS-CoV-2 is the cornerstone for public health control of the pandemic and vaccine development. However, current evidence is rather based on limited measurements, thus losing sight of the temporal pattern of these changes1–6. In this longitudinal analysis, conducted on a prospective cohort of COVID-19 patients followed up to 242 days, we found that individuals with mild or asymptomatic infection experienced an insignificant decay in neutralizing activity that persisted six months after symptom onset or diagnosis. Hospitalized individuals showed higher neutralizing titers, which decreased following a two-phase pattern, with an initial rapid decline that significantly slowed after day 80. Despite this initial decay, neutralizing activity at six months remained higher among hospitalized individuals. The slow decline in neutralizing activity at mid-term contrasted with the steep slope of antibody titers change, reinforcing the hypothesis that the quality of immune response evolves over the post-convalescent stage4,5.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted November 24, 2020.
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Stable neutralizing antibody levels six months after mild and severe COVID-19 episode
Edwards Pradenas, Benjamin Trinité, Víctor Urrea, Silvia Marfil, Carlos Ávila-Nieto, María Luisa Rodríguez de la Concepción, Ferran Tarrés-Freixas, Silvia Pérez-Yanes, Carla Rovirosa, Erola Ainsua-Enrich, Jordi Rodon, Júlia Vergara-Alert, Joaquim Segalés, Victor Guallar, Alfonso Valencia, Nuria Izquierdo-Useros, Roger Paredes, Lourdes Mateu, Anna Chamorro, Marta Massanella, Jorge Carrillo, Bonaventura Clotet, Julià Blanco
bioRxiv 2020.11.22.389056; doi: https://doi.org/10.1101/2020.11.22.389056
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Stable neutralizing antibody levels six months after mild and severe COVID-19 episode
Edwards Pradenas, Benjamin Trinité, Víctor Urrea, Silvia Marfil, Carlos Ávila-Nieto, María Luisa Rodríguez de la Concepción, Ferran Tarrés-Freixas, Silvia Pérez-Yanes, Carla Rovirosa, Erola Ainsua-Enrich, Jordi Rodon, Júlia Vergara-Alert, Joaquim Segalés, Victor Guallar, Alfonso Valencia, Nuria Izquierdo-Useros, Roger Paredes, Lourdes Mateu, Anna Chamorro, Marta Massanella, Jorge Carrillo, Bonaventura Clotet, Julià Blanco
bioRxiv 2020.11.22.389056; doi: https://doi.org/10.1101/2020.11.22.389056

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