The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by pausing POL II at pro-differentiation genes

Görkem Garipler; Congyi Lu; Alexis Morrissey; Lorena S. Lopez-Zepeda; Simon E. Vidal; Begüm Aydin; Matthias Stadtfeld; Uwe Ohler; Shaun Mahony; Neville E. Sanjana; Esteban O. Mazzoni

doi:10.1101/2020.11.23.391771

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The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by pausing POL II at pro-differentiation genes

Görkem Garipler, Congyi Lu, Alexis Morrissey, Lorena S. Lopez-Zepeda, Simon E. Vidal, Begüm Aydin, Matthias Stadtfeld, Uwe Ohler, View ORCID ProfileShaun Mahony, Neville E. Sanjana, View ORCID ProfileEsteban O. Mazzoni

doi: https://doi.org/10.1101/2020.11.23.391771

Görkem Garipler

1Department of Biology, New York University, New York, NY 10003, USA

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Congyi Lu

1Department of Biology, New York University, New York, NY 10003, USA

2New York Genome Center, New York, NY, 10013 USA

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Alexis Morrissey

3Center for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, Penn State University, PA 16801, USA

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Lorena S. Lopez-Zepeda

4Department of Biology, Humboldt Universität zu Berlin, Berlin 10117, Germany

5Berlin Institute for Medical Systems Biology, Max-Delbrück-Center for Molecular Medicine, Berlin 13125, Germany

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Simon E. Vidal

6Skirball Institute of Biomolecular Medicine, Department of Cell Biology, NYU Langone Medical Center, New York, NY 10016, USA

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Begüm Aydin

1Department of Biology, New York University, New York, NY 10003, USA

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Matthias Stadtfeld

6Skirball Institute of Biomolecular Medicine, Department of Cell Biology, NYU Langone Medical Center, New York, NY 10016, USA

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Uwe Ohler

4Department of Biology, Humboldt Universität zu Berlin, Berlin 10117, Germany

5Berlin Institute for Medical Systems Biology, Max-Delbrück-Center for Molecular Medicine, Berlin 13125, Germany

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Shaun Mahony

3Center for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, Penn State University, PA 16801, USA

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ORCID record for Shaun Mahony

Neville E. Sanjana

1Department of Biology, New York University, New York, NY 10003, USA

2New York Genome Center, New York, NY, 10013 USA

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For correspondence: neville@sanjanalab.org eom204@nyu.edu

Esteban O. Mazzoni

1Department of Biology, New York University, New York, NY 10003, USA

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ORCID record for Esteban O. Mazzoni
For correspondence: neville@sanjanalab.org eom204@nyu.edu

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Posted November 23, 2020.

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The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by pausing POL II at pro-differentiation genes

Görkem Garipler, Congyi Lu, Alexis Morrissey, Lorena S. Lopez-Zepeda, Simon E. Vidal, Begüm Aydin, Matthias Stadtfeld, Uwe Ohler, Shaun Mahony, Neville E. Sanjana, Esteban O. Mazzoni

bioRxiv 2020.11.23.391771; doi: https://doi.org/10.1101/2020.11.23.391771

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The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by pausing POL II at pro-differentiation genes

Görkem Garipler, Congyi Lu, Alexis Morrissey, Lorena S. Lopez-Zepeda, Simon E. Vidal, Begüm Aydin, Matthias Stadtfeld, Uwe Ohler, Shaun Mahony, Neville E. Sanjana, Esteban O. Mazzoni

bioRxiv 2020.11.23.391771; doi: https://doi.org/10.1101/2020.11.23.391771

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