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Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns

Jagat Krishna Chhipi Shrestha, Tilman Schneider-Poetsch, Takehiro Suzuki, Mari Mito, Khalid Khan, Naoshi Dohmae, View ORCID ProfileShintaro Iwasaki, View ORCID ProfileMinoru Yoshida
doi: https://doi.org/10.1101/2020.11.23.393835
Jagat Krishna Chhipi Shrestha
1Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan
2Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
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Tilman Schneider-Poetsch
1Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan
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Takehiro Suzuki
3Biomolecular Characterization Unit, Technology Platform Division, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan
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Mari Mito
4RNA Systems Biochemistry Laboratory, RIKEN Cluster for Pioneering Research, Wako, Saitama 351-0198, Japan
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Khalid Khan
1Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan
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Naoshi Dohmae
3Biomolecular Characterization Unit, Technology Platform Division, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan
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Shintaro Iwasaki
4RNA Systems Biochemistry Laboratory, RIKEN Cluster for Pioneering Research, Wako, Saitama 351-0198, Japan
5Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba 277-8561, Japan
6AMED-CREST, Japan Agency for Medical Research and Development, Wako, Saitama 351-0198, Japan
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  • ORCID record for Shintaro Iwasaki
  • For correspondence: shintaro.iwasaki@riken.jp yoshidam@riken.jp
Minoru Yoshida
1Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan
2Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
7Collaborative Research Institute for Innovative Microbiology, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
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  • ORCID record for Minoru Yoshida
  • For correspondence: shintaro.iwasaki@riken.jp yoshidam@riken.jp
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Article Information

doi 
https://doi.org/10.1101/2020.11.23.393835
History 
  • November 23, 2020.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Jagat Krishna Chhipi Shrestha1,2,
  2. Tilman Schneider-Poetsch1,
  3. Takehiro Suzuki3,
  4. Mari Mito4,
  5. Khalid Khan1,
  6. Naoshi Dohmae3,
  7. Shintaro Iwasaki4,5,6,8,* and
  8. Minoru Yoshida1,2,7,*
  1. 1Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan
  2. 2Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
  3. 3Biomolecular Characterization Unit, Technology Platform Division, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan
  4. 4RNA Systems Biochemistry Laboratory, RIKEN Cluster for Pioneering Research, Wako, Saitama 351-0198, Japan
  5. 5Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba 277-8561, Japan
  6. 6AMED-CREST, Japan Agency for Medical Research and Development, Wako, Saitama 351-0198, Japan
  7. 7Collaborative Research Institute for Innovative Microbiology, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
  1. ↵*Correspondence should be addressed to S.I. and M.Y. E-mail: shintaro.iwasaki{at}riken.jp and yoshidam{at}riken.jp
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Posted November 23, 2020.
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Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns
Jagat Krishna Chhipi Shrestha, Tilman Schneider-Poetsch, Takehiro Suzuki, Mari Mito, Khalid Khan, Naoshi Dohmae, Shintaro Iwasaki, Minoru Yoshida
bioRxiv 2020.11.23.393835; doi: https://doi.org/10.1101/2020.11.23.393835
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Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns
Jagat Krishna Chhipi Shrestha, Tilman Schneider-Poetsch, Takehiro Suzuki, Mari Mito, Khalid Khan, Naoshi Dohmae, Shintaro Iwasaki, Minoru Yoshida
bioRxiv 2020.11.23.393835; doi: https://doi.org/10.1101/2020.11.23.393835

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