Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns

Jagat Krishna Chhipi Shrestha; Tilman Schneider-Poetsch; Takehiro Suzuki; Mari Mito; Khalid Khan; Naoshi Dohmae; Shintaro Iwasaki; Minoru Yoshida

doi:10.1101/2020.11.23.393835

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Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns

Jagat Krishna Chhipi Shrestha, Tilman Schneider-Poetsch, Takehiro Suzuki, Mari Mito, Khalid Khan, Naoshi Dohmae, View ORCID ProfileShintaro Iwasaki, View ORCID ProfileMinoru Yoshida

doi: https://doi.org/10.1101/2020.11.23.393835

Jagat Krishna Chhipi Shrestha

1Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan

2Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan

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Tilman Schneider-Poetsch

1Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan

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Takehiro Suzuki

3Biomolecular Characterization Unit, Technology Platform Division, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan

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Mari Mito

4RNA Systems Biochemistry Laboratory, RIKEN Cluster for Pioneering Research, Wako, Saitama 351-0198, Japan

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Khalid Khan

1Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan

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Naoshi Dohmae

3Biomolecular Characterization Unit, Technology Platform Division, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan

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Shintaro Iwasaki

4RNA Systems Biochemistry Laboratory, RIKEN Cluster for Pioneering Research, Wako, Saitama 351-0198, Japan

5Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba 277-8561, Japan

6AMED-CREST, Japan Agency for Medical Research and Development, Wako, Saitama 351-0198, Japan

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ORCID record for Shintaro Iwasaki
For correspondence: shintaro.iwasaki@riken.jp yoshidam@riken.jp

Minoru Yoshida

1Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan

2Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan

7Collaborative Research Institute for Innovative Microbiology, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan

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ORCID record for Minoru Yoshida
For correspondence: shintaro.iwasaki@riken.jp yoshidam@riken.jp

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Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns

Jagat Krishna Chhipi Shrestha, Tilman Schneider-Poetsch, Takehiro Suzuki, Mari Mito, Khalid Khan, Naoshi Dohmae, Shintaro Iwasaki, Minoru Yoshida

bioRxiv 2020.11.23.393835; doi: https://doi.org/10.1101/2020.11.23.393835

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Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns

Jagat Krishna Chhipi Shrestha, Tilman Schneider-Poetsch, Takehiro Suzuki, Mari Mito, Khalid Khan, Naoshi Dohmae, Shintaro Iwasaki, Minoru Yoshida

bioRxiv 2020.11.23.393835; doi: https://doi.org/10.1101/2020.11.23.393835

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