find-tfbs: a tool to identify functional non-coding variants associated with complex human traits using open chromatin maps and phased whole-genome sequences

Sébastian Méric de Bellefon; Florian Thibord; Paul L. Auer; John Blangero; Zeynep H Coban-Akdemir; James S. Floyd; Myriam Fornage; Jill M. Johnsen; Leslie A. Lange; Joshua P. Lewis; Rasika A. Mathias; Caitlin P. McHugh; Jee-Young Moon; Alex P. Reiner; Adrienne M. Stilp; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Guillaume Lettre

doi:10.1101/2020.11.23.394296

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find-tfbs: a tool to identify functional non-coding variants associated with complex human traits using open chromatin maps and phased whole-genome sequences

Sébastian Méric de Bellefon, Florian Thibord, Paul L. Auer, John Blangero, Zeynep H Coban-Akdemir, James S. Floyd, Myriam Fornage, Jill M. Johnsen, Leslie A. Lange, Joshua P. Lewis, Rasika A. Mathias, Caitlin P. McHugh, Jee-Young Moon, Alex P. Reiner, Adrienne M. Stilp, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Guillaume Lettre

doi: https://doi.org/10.1101/2020.11.23.394296

Sébastian Méric de Bellefon

1Montreal Heart Institute, Montreal, Quebec, H1T 1C8, Canada

2Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, H3T 1J4, Canada

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For correspondence: guillaume.lettre@mhi-humangenetics.org

Florian Thibord

3Population Sciences Branch, The Framingham Heart Study, Division of Intramural Research, National Heart, Lung, and Blood Institute, Framingham, MA, 01702, USA

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Paul L. Auer

4Department of Biostatistics, Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, 53201, USA

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John Blangero

5Department of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX, 78520, USA

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Zeynep H Coban-Akdemir

6Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, UTexas Health Science Center, Houston, TX, 77030, USA

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James S. Floyd

7Departments of Medicine and Epidemiology, University of Washington, Seattle, WA, 98101, USA

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Myriam Fornage

8Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA

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Jill M. Johnsen

9Research Institute, Bloodworks, Seattle, WA, 98102, USA

10Department of Medicine, Division of Hematology, University of Washington, Seattle, WA, 98102, USA

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Leslie A. Lange

11Division of Biomedical Informatics & Personalized Medicine, School of Medicine, CU Anschutz Medical Campus, Aurora, CO, 80045, USA

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Joshua P. Lewis

12Department of Medicine, Division of Endocrinology, Diabetes, and Nutrition, University of Maryland, Baltimore, MD, 21201, USA

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Rasika A. Mathias

13Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA

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Caitlin P. McHugh

14Department of Biostatistics, University of Washington, Seattle, WA, 98195, USA

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Jee-Young Moon

15Department of Epidemiology and Population Health, Gillings School of Global Public Health, Albert Einstein College of Medicine, Bronx, NY, 10461, USA

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Alex P. Reiner

16Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, 98109, USA

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Adrienne M. Stilp

14Department of Biostatistics, University of Washington, Seattle, WA, 98195, USA

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Guillaume Lettre

1Montreal Heart Institute, Montreal, Quebec, H1T 1C8, Canada

2Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, H3T 1J4, Canada

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For correspondence: guillaume.lettre@mhi-humangenetics.org

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find-tfbs: a tool to identify functional non-coding variants associated with complex human traits using open chromatin maps and phased whole-genome sequences

bioRxiv 2020.11.23.394296; doi: https://doi.org/10.1101/2020.11.23.394296

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find-tfbs: a tool to identify functional non-coding variants associated with complex human traits using open chromatin maps and phased whole-genome sequences

bioRxiv 2020.11.23.394296; doi: https://doi.org/10.1101/2020.11.23.394296

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