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Prefrontal cortical activity predicts the extra-place field spiking of hippocampal place cells

View ORCID ProfileJai Y. Yu, View ORCID ProfileLoren M. Frank
doi: https://doi.org/10.1101/2020.11.23.395012
Jai Y. Yu
1Department of Psychology, Institute for Mind and Biology, Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior, The University of Chicago
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  • For correspondence: jaiyu@uchicago.edu
Loren M. Frank
2Howard Hughes Medical Institute, Kavli Institute for Fundamental Neuroscience, Departments of Physiology and Psychiatry, University of California, San Francisco
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Abstract

The receptive field of a neuron describes the regions of a stimulus space where the neuron is consistently active. Sparse spiking outside of the receptive field is often considered to be noise, rather than a reflection of information processing. Whether this characterization is accurate remains unclear. We therefore contrasted the sparse, temporally isolated spiking of hippocampal CA1 place cells to the consistent, temporally adjacent spiking seen within their spatial receptive fields (“place fields”). We found that isolated spikes, which occur during locomotion, are more strongly phase coupled to hippocampal theta oscillations than adjacent spikes and, surprisingly, transiently express coherent representations of non-local spatial representations. Further, prefrontal cortical activity is coordinated with, and can predict the occurrence of future isolated spiking events. Rather than local noise within the hippocampus, sparse, isolated place cell spiking reflects a coordinated cortical-hippocampal process consistent with the generation of non-local scenario representations during active navigation.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted November 24, 2020.
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Prefrontal cortical activity predicts the extra-place field spiking of hippocampal place cells
Jai Y. Yu, Loren M. Frank
bioRxiv 2020.11.23.395012; doi: https://doi.org/10.1101/2020.11.23.395012
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Prefrontal cortical activity predicts the extra-place field spiking of hippocampal place cells
Jai Y. Yu, Loren M. Frank
bioRxiv 2020.11.23.395012; doi: https://doi.org/10.1101/2020.11.23.395012

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