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MNI-FTD Templates: Unbiased Average Templates of Frontotemporal Dementia Variants

Mahsa Dadar, Ana L. Manera, Vladimir S. Fonov, Simon Ducharme, D. Louis Collins
doi: https://doi.org/10.1101/2020.11.25.398305
Mahsa Dadar
1McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec (QC), Canada
2CERVO Brain Research Center, Centre intégré universitaire santé et services sociaux de la Capitale Nationale, Québec, QC
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  • For correspondence: mahsa.dadar@mail.mcgill.ca
Ana L. Manera
1McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec (QC), Canada
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Vladimir S. Fonov
1McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec (QC), Canada
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Simon Ducharme
1McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec (QC), Canada
3Douglas Mental Health University Institute, Department of Psychiatry, 6875 Boulevard LaSalle, Verdun, QC H4H 1R3
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D. Louis Collins
1McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec (QC), Canada
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  • Abstract
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Abstract

Standard anatomical templates are widely used in human neuroimaging processing pipelines to facilitate group level analyses and comparisons across different subjects and populations. The MNI-ICBM152 template is the most commonly used standard template, representing an average of 152 healthy young adult brains. However, in patients with neurodegenerative diseases such as frontotemporal dementia (FTD), the high levels of atrophy lead to significant differences between the brain shape of the individuals and the MNI-ICBM152 template. Such differences might inevitably lead to registration errors or subtle biases in downstream analyses and results. Disease-specific templates are therefore desirable to reflect the anatomical characteristics of the populations of interest and to reduce potential registration errors when processing data from such populations.

Here, we present MNI-FTD136, MNI-bvFTD70, MNI-svFTD36, and MNI-pnfaFTD30, four unbiased average templates of 136 FTD patients, 70 behavioural variant (bv), 36 semantic variant (sv), and 30 progressive nonfluent aphasia (pnfa) variant FTD patients as well as a corresponding age matched average template of 133 healthy controls (MNI-CN133), along with probabilistic tissue maps for each template. The public availability of these templates will facilitate analyses of FTD cohorts and enable comparisons between different studies in a common standardized space appropriate to FTD populations.

Competing Interest Statement

The authors have declared no competing interest.

  • Abbreviations

    bvFTD
    Behavioural variant frontotemporal dementia
    CSF
    Cerebrospinal fluid
    FTD
    Frontotemporal dementia
    GM
    gray matter
    MRI
    magnetic resonance imaging
    MNI
    Montreal Neurological Institute
    pnfaFTD
    progressive nonfluent aphasia frontotemporal dementia
    svFTD
    Semantic variant frontotemporal dementia
    T1w
    T1-weighted
    WM
    white matter
  • Copyright 
    The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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    Posted November 29, 2020.
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    MNI-FTD Templates: Unbiased Average Templates of Frontotemporal Dementia Variants
    Mahsa Dadar, Ana L. Manera, Vladimir S. Fonov, Simon Ducharme, D. Louis Collins
    bioRxiv 2020.11.25.398305; doi: https://doi.org/10.1101/2020.11.25.398305
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    MNI-FTD Templates: Unbiased Average Templates of Frontotemporal Dementia Variants
    Mahsa Dadar, Ana L. Manera, Vladimir S. Fonov, Simon Ducharme, D. Louis Collins
    bioRxiv 2020.11.25.398305; doi: https://doi.org/10.1101/2020.11.25.398305

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