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Effect of RBD mutation (Y453F) in spike glycoprotein of SARS-CoV-2 on neutralizing antibody affinity

Takuma Hayashi, Nobuo Yaegashi, Ikuo Konishi
doi: https://doi.org/10.1101/2020.11.27.401893
Takuma Hayashi
1National Hospital Organization Kyoto Medical Center, Kyoto, Japan
2START, Japan Science and Technology Agency (JST), Tokyo, Japan
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  • For correspondence: yoyoyo224@hotmail.com
Nobuo Yaegashi
3Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Miyagi, Japan
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Ikuo Konishi
1National Hospital Organization Kyoto Medical Center, Kyoto, Japan
4Department of Obstetrics and Gynecology, Kyoto University School of Medicine, Kyoto, Japan
5Immediate Past President, Asian Society of Gynecologic Oncology, Tokyo, Japan
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Abstract

Natural selection “adaptation” in the coronavirus can occur during coronavirus amplification in vivo in farmed minks. Natural selection in such viruses is observed by introduction of mutations in SARS- CoV-2 that are not observed during the growth process in humans. Infection with a mutant (Y453F) of SARS-CoV-2 from farmed minks is known to widely spread among humans. We investigated the virological characteristics of this SARS-CoV-2 mutant (Y453F) using three-dimensional protein structural analysis. Our experimental study suggests that virus variants with the Y453F mutation partially escaped detection by four neutralizing monoclonal antibodies. The spread of SARS-CoV-2 variants mediated by millions of infected farmed minks is uncontrolled; consequently, raising a concern that infection of SARS-CoV-2 mutants that cause serious symptoms in humans may spread globally.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted November 28, 2020.
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Effect of RBD mutation (Y453F) in spike glycoprotein of SARS-CoV-2 on neutralizing antibody affinity
Takuma Hayashi, Nobuo Yaegashi, Ikuo Konishi
bioRxiv 2020.11.27.401893; doi: https://doi.org/10.1101/2020.11.27.401893
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Effect of RBD mutation (Y453F) in spike glycoprotein of SARS-CoV-2 on neutralizing antibody affinity
Takuma Hayashi, Nobuo Yaegashi, Ikuo Konishi
bioRxiv 2020.11.27.401893; doi: https://doi.org/10.1101/2020.11.27.401893

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