Design of proteins presenting discontinuous functional sites using deep learning

Doug Tischer; Sidney Lisanza; Jue Wang; Runze Dong; Ivan Anishchenko; Lukas F. Milles; Sergey Ovchinnikov; David Baker

doi:10.1101/2020.11.29.402743

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Design of proteins presenting discontinuous functional sites using deep learning

View ORCID ProfileDoug Tischer, Sidney Lisanza, Jue Wang, Runze Dong, View ORCID ProfileIvan Anishchenko, Lukas F. Milles, Sergey Ovchinnikov, David Baker

doi: https://doi.org/10.1101/2020.11.29.402743

Doug Tischer

aDepartment of Biochemistry, University of Washington, Seattle, WA 98105, USA

bInstitute for Protein Design, University of Washington, Seattle, WA 98105, USA

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ORCID record for Doug Tischer

Sidney Lisanza

aDepartment of Biochemistry, University of Washington, Seattle, WA 98105, USA

bInstitute for Protein Design, University of Washington, Seattle, WA 98105, USA

cGraduate program in Biological Physics, Structure and Design, University of Washington, Seattle, WA 98105, USA

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Jue Wang

aDepartment of Biochemistry, University of Washington, Seattle, WA 98105, USA

bInstitute for Protein Design, University of Washington, Seattle, WA 98105, USA

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Runze Dong

aDepartment of Biochemistry, University of Washington, Seattle, WA 98105, USA

bInstitute for Protein Design, University of Washington, Seattle, WA 98105, USA

cGraduate program in Biological Physics, Structure and Design, University of Washington, Seattle, WA 98105, USA

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Ivan Anishchenko

aDepartment of Biochemistry, University of Washington, Seattle, WA 98105, USA

bInstitute for Protein Design, University of Washington, Seattle, WA 98105, USA

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ORCID record for Ivan Anishchenko

Lukas F. Milles

aDepartment of Biochemistry, University of Washington, Seattle, WA 98105, USA

bInstitute for Protein Design, University of Washington, Seattle, WA 98105, USA

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Sergey Ovchinnikov

dFAS Division of Science, Harvard University, Cambridge, MA 02138, USA

eJohn Harvard Distinguished Science Fellowship Program, Harvard University, Cambridge, MA 02138, USA

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David Baker

aDepartment of Biochemistry, University of Washington, Seattle, WA 98105, USA

bInstitute for Protein Design, University of Washington, Seattle, WA 98105, USA

fHoward Hughes Medical Institute, University of Washington, Seattle, WA 98105, USA

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For correspondence: dabaker@uw.edu so@fas.harvard.edu

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Design of proteins presenting discontinuous functional sites using deep learning

Doug Tischer, Sidney Lisanza, Jue Wang, Runze Dong, Ivan Anishchenko, Lukas F. Milles, Sergey Ovchinnikov, David Baker

bioRxiv 2020.11.29.402743; doi: https://doi.org/10.1101/2020.11.29.402743

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Design of proteins presenting discontinuous functional sites using deep learning

Doug Tischer, Sidney Lisanza, Jue Wang, Runze Dong, Ivan Anishchenko, Lukas F. Milles, Sergey Ovchinnikov, David Baker

bioRxiv 2020.11.29.402743; doi: https://doi.org/10.1101/2020.11.29.402743

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