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RUNX1 controls the dynamics of cell cycle entry of naïve resting B cells by regulating expression of cell cycle and immunomodulatory genes in response to BCR stimulation

Inesa Thomsen, Natalia Kunowska, Roshni de Souza, Anne-Marie Moody, Greg Crawford, Yi-Fang Wang, Sanjay Khadayate, Jessica Strid, Mohammad M. Karimi, Alexis Barr, Niall Dillon, Pierangela Sabbattini
doi: https://doi.org/10.1101/2020.12.01.406744
Inesa Thomsen
1Gene Regulation and Chromatin Group, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.
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Natalia Kunowska
1Gene Regulation and Chromatin Group, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.
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Roshni de Souza
1Gene Regulation and Chromatin Group, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.
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Anne-Marie Moody
1Gene Regulation and Chromatin Group, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.
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Greg Crawford
2Department of Immunology and Inflammation, Imperial College London, Hammersmith Hospital Campus, Du Cane London W12 0NN, UK.
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Yi-Fang Wang
3Bioinformatics and Computing, MRC London Institute of Medical Sciences, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.
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Sanjay Khadayate
3Bioinformatics and Computing, MRC London Institute of Medical Sciences, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.
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Jessica Strid
2Department of Immunology and Inflammation, Imperial College London, Hammersmith Hospital Campus, Du Cane London W12 0NN, UK.
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Mohammad M. Karimi
3Bioinformatics and Computing, MRC London Institute of Medical Sciences, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.
4Comprehensive Cancer Centre, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King’s College London, London SE5 8AF, UK
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Alexis Barr
5Cell Cycle Control Group, MRC London Institute of Medical Sciences, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.
6Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.
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Niall Dillon
1Gene Regulation and Chromatin Group, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.
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  • For correspondence: niall.dillon@lms.mrc.ac.uk
Pierangela Sabbattini
1Gene Regulation and Chromatin Group, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.
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Article Information

doi 
https://doi.org/10.1101/2020.12.01.406744
History 
  • December 2, 2020.

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  • You are currently viewing Version 1 of this article (December 2, 2020 - 15:20).
  • View Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Inesa Thomsen1,
  2. Natalia Kunowska1,
  3. Roshni de Souza1,
  4. Anne-Marie Moody1,
  5. Greg Crawford2,
  6. Yi-Fang Wang3,
  7. Sanjay Khadayate3,
  8. Jessica Strid2,
  9. Mohammad M. Karimi3,4,
  10. Alexis Barr5,6,
  11. Niall Dillon1,* and
  12. Pierangela Sabbattini1
  1. 1Gene Regulation and Chromatin Group, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.
  2. 2Department of Immunology and Inflammation, Imperial College London, Hammersmith Hospital Campus, Du Cane London W12 0NN, UK.
  3. 3Bioinformatics and Computing, MRC London Institute of Medical Sciences, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.
  4. 4Comprehensive Cancer Centre, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King’s College London, London SE5 8AF, UK
  5. 5Cell Cycle Control Group, MRC London Institute of Medical Sciences, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.
  6. 6Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.
  1. ↵*Correspondence to niall.dillon{at}lms.mrc.ac.uk
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Posted December 02, 2020.
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RUNX1 controls the dynamics of cell cycle entry of naïve resting B cells by regulating expression of cell cycle and immunomodulatory genes in response to BCR stimulation
Inesa Thomsen, Natalia Kunowska, Roshni de Souza, Anne-Marie Moody, Greg Crawford, Yi-Fang Wang, Sanjay Khadayate, Jessica Strid, Mohammad M. Karimi, Alexis Barr, Niall Dillon, Pierangela Sabbattini
bioRxiv 2020.12.01.406744; doi: https://doi.org/10.1101/2020.12.01.406744
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RUNX1 controls the dynamics of cell cycle entry of naïve resting B cells by regulating expression of cell cycle and immunomodulatory genes in response to BCR stimulation
Inesa Thomsen, Natalia Kunowska, Roshni de Souza, Anne-Marie Moody, Greg Crawford, Yi-Fang Wang, Sanjay Khadayate, Jessica Strid, Mohammad M. Karimi, Alexis Barr, Niall Dillon, Pierangela Sabbattini
bioRxiv 2020.12.01.406744; doi: https://doi.org/10.1101/2020.12.01.406744

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