Abstract
Despite a five-order magnitude range in size, the mammalian brain exhibits many shared anatomical and functional characteristics that should translate into cortical network commonalities. Here we develop a framework employing machine learning to quantify the degree of predictability of the weighted interareal cortical matrix. Data were obtained with retrograde tract-tracing experiments supplemented by projection length measurements. Using this framework with consistent and edge-complete empirical datasets in the macaque and mouse cortex, we show that there is significant amount of predictability embedded in the interareal cortical networks of both species. At the binary level, links are predictable with an Area Under the ROC curve of at least 0.8 for the macaque. At the weighted level, strengths of the medium and strong links are predictable with at least 85-90% accuracy in mouse and 70-80% in macaque, whereas weak links are not predictable in either species. These observations suggest that the formation and evolution of the cortical network at the mesoscale is to a large extent, rule-based, motivating further research on the architectural invariants of the cortical connectome.
Competing Interest Statement
The authors have declared no competing interest.
Footnotes
Author Contributions FM and ZT designed the research, FM wrote all the prediction algorithms and ran the simulations, SzH, ARG and ME-R contributed to the computational and data analysis, ARG, KK and HK collected and provided the experimental datasets, ZT and FM wrote the paper and all authors contributed to editing the paper.
