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Grid cell firing fields in a volumetric space

View ORCID ProfileRoddy M. Grieves, View ORCID ProfileSelim Jedidi-Ayoub, View ORCID ProfileKaryna Mishchanchuk, View ORCID ProfileAnyi Liu, Sophie Renaudineau, View ORCID ProfileÉléonore Duvelle, View ORCID ProfileKate J. Jeffery
doi: https://doi.org/10.1101/2020.12.06.413542
Roddy M. Grieves
1Department of Experimental Psychology, Institute of Behavioural Neuroscience, University College London, London, UK
2Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, USA
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  • For correspondence: r.grieves@ucl.ac.uk k.jeffery@ucl.ac.uk
Selim Jedidi-Ayoub
1Department of Experimental Psychology, Institute of Behavioural Neuroscience, University College London, London, UK
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Karyna Mishchanchuk
1Department of Experimental Psychology, Institute of Behavioural Neuroscience, University College London, London, UK
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  • ORCID record for Karyna Mishchanchuk
Anyi Liu
1Department of Experimental Psychology, Institute of Behavioural Neuroscience, University College London, London, UK
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Sophie Renaudineau
1Department of Experimental Psychology, Institute of Behavioural Neuroscience, University College London, London, UK
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Éléonore Duvelle
1Department of Experimental Psychology, Institute of Behavioural Neuroscience, University College London, London, UK
2Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, USA
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Kate J. Jeffery
1Department of Experimental Psychology, Institute of Behavioural Neuroscience, University College London, London, UK
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  • ORCID record for Kate J. Jeffery
  • For correspondence: r.grieves@ucl.ac.uk k.jeffery@ucl.ac.uk
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Abstract

We investigated how entorhinal grid cells represent volumetric (three-dimensional) space. On a flat surface, grid cell firing fields are circular and arranged in a close-packed hexagonal array. In three dimensions, theoretical and computational work suggests that the most efficient configuration would be a regular close packing of spherical fields. We report that in rats exploring a cubic lattice, grid cells were spatially stable and maintained normal directional modulation, theta modulation and spike dynamics. However, while the majority of grid fields were spherical, they were irregularly arranged, even when only fields abutting the lower surface (equivalent to the floor) were considered. Thus, grid organization is shaped by the environment’s movement affordances, and may not need to be regular to support spatial computations.

One Sentence Summary In rats exploring a volumetric space, grid cells are spatially modulated but their firing fields are irregularly arranged.

Competing Interest Statement

The Authors declare the following competing interests: K.J. is a non-shareholding director of Axona Ltd.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted December 07, 2020.
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Grid cell firing fields in a volumetric space
Roddy M. Grieves, Selim Jedidi-Ayoub, Karyna Mishchanchuk, Anyi Liu, Sophie Renaudineau, Éléonore Duvelle, Kate J. Jeffery
bioRxiv 2020.12.06.413542; doi: https://doi.org/10.1101/2020.12.06.413542
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Grid cell firing fields in a volumetric space
Roddy M. Grieves, Selim Jedidi-Ayoub, Karyna Mishchanchuk, Anyi Liu, Sophie Renaudineau, Éléonore Duvelle, Kate J. Jeffery
bioRxiv 2020.12.06.413542; doi: https://doi.org/10.1101/2020.12.06.413542

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