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Distinctive functional regime of endogenous lncRNAs in dark regions of human genome

View ORCID ProfileAnyou Wang, Rong Hai
doi: https://doi.org/10.1101/2020.12.06.413880
Anyou Wang
1The Institute for Integrative Genome Biology, University of California at Riverside, Riverside, CA 92521, USA
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  • For correspondence: anyou.wang@alumni.ucr.edu
Rong Hai
1The Institute for Integrative Genome Biology, University of California at Riverside, Riverside, CA 92521, USA
2Department of Microbiology and Plant Pathology, University of California at Riverside, Riverside, CA 92521, USA
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Abstract

Eukaryotic genomes gradually gain noncoding regions when advancing evolution and human genome actively transcribes >90% of its noncoding regions1, suggesting their criticality in evolutionary human genome. Yet <1% of them have been functionally characterized2, leaving most human genome in dark. Here we systematically decode endogenous lncRNAs located in unannotated regions of human genome and decipher a distinctive functional regime of lncRNAs hidden in massive RNAseq data. LncRNAs divergently distribute across chromosomes, independent of protein-coding regions. Their transcriptions barely initiate on promoters through polymerase II, but mostly on enhancers. Yet conventional enhancer activators(e.g. H3K4me1) only account for a small proportion of lncRNA activation, suggesting alternatively unknown mechanisms initiating the majority of lncRNAs. Meanwhile, lncRNA-self regulation also notably contributes to lncRNA activation. LncRNAs trans-regulate broad bioprocesses, including transcription and RNA processing, cell cycle, respiration, response to stress, chromatin organization, post-translational modification, and development. Overall lncRNAs govern their owned regime distinctive from protein’s.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • https://combai.org/network/lncRNA/

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted December 07, 2020.
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Distinctive functional regime of endogenous lncRNAs in dark regions of human genome
Anyou Wang, Rong Hai
bioRxiv 2020.12.06.413880; doi: https://doi.org/10.1101/2020.12.06.413880
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Distinctive functional regime of endogenous lncRNAs in dark regions of human genome
Anyou Wang, Rong Hai
bioRxiv 2020.12.06.413880; doi: https://doi.org/10.1101/2020.12.06.413880

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