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A data-driven predictome for cognitive, psychiatric, medical, and lifestyle factors on the brain

Syed Fahad Sultan, Lilianne R. Mujica Parodi, Steven Skiena
doi: https://doi.org/10.1101/2020.12.07.415091
Syed Fahad Sultan
1Stony Brook University, Department of Computer Science, Stony Brook, 11790, USA
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Lilianne R. Mujica Parodi
2Stony Brook University, Department of Biomedical Engineering, Stony Brook, 11790, USA
3Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, Boston, 02129, USA
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Steven Skiena
1Stony Brook University, Department of Computer Science, Stony Brook, 11790, USA
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  • For correspondence: skiena@cs.stonybrook.edu
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ABSTRACT

Most neuroimaging studies individually provide evidence on a narrow aspect of the human brain function, on distinct data sets that often suffer from small sample sizes. More generally, the high technical and cost demands of neuroimaging studies (combined with the statistical unreliability of neuroimaging pilot studies) may lead to observational bias, discouraging discovery of less obvious associations that nonetheless have important neurological implications. To address these problems, we built a machine-learning based classification framework, NeuroPredictome, optimized for the reliability and robustness of its associations. NeuroPredictome is grounded in a large-scale dataset, UK-Biobank (N=19,831), which includes resting and task functional MRI as well as structural T1-weighted and diffusion tensor imaging. Participants were assessed with respect to a comprehensive set of 5,034 phenotypes, including the physical and lifestyle factors most relevant to general medicine. Results generated by data-driven classifiers were then cross-validated, using deep-learning textual analyses, against 14,371 peer-reviewed research articles, providing an unbiased hypothesis-generator of linkages between diverse phenotypes and the brain. Our results show that neuroimaging reveals as many neurological links to physical and lifestyle factors as to cognitive factors, supporting a more integrative approach to medicine that considers disease interactions between multiple organs and systems.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • http://www.neuropredictome.com

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted December 08, 2020.
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A data-driven predictome for cognitive, psychiatric, medical, and lifestyle factors on the brain
Syed Fahad Sultan, Lilianne R. Mujica Parodi, Steven Skiena
bioRxiv 2020.12.07.415091; doi: https://doi.org/10.1101/2020.12.07.415091
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A data-driven predictome for cognitive, psychiatric, medical, and lifestyle factors on the brain
Syed Fahad Sultan, Lilianne R. Mujica Parodi, Steven Skiena
bioRxiv 2020.12.07.415091; doi: https://doi.org/10.1101/2020.12.07.415091

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