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Robust integrated intracellular organization of the human iPS cell: where, how much, and how variable
Matheus P. Viana, Jianxu Chen, Theo A. Knijnenburg, Ritvik Vasan, Calysta Yan, Joy E. Arakaki, Matte Bailey, Ben Berry, Antoine Borensztejn, Jackson M. Brown, Sara Carlson, Julie A. Cass, Basudev Chaudhuri, Kimberly R. Cordes Metzler, Mackenzie E. Coston, Zach J. Crabtree, Steve Davidson, Colette M. DeLizo, Shailja Dhaka, Stephanie Q. Dinh, Thao P. Do, Justin Domingus, Rory M. Donovan-Maiye, Tyler J. Foster, Christopher L. Frick, Griffin Fujioka, Margaret A. Fuqua, Jamie L. Gehring, Kaytlyn A. Gerbin, Tanya Grancharova, Benjamin W. Gregor, Lisa J. Harrylock, Amanda Haupt, Melissa C. Hendershott, Caroline Hookway, Alan R. Horwitz, Chris Hughes, Eric J. Isaac, Gregory R. Johnson, Brian Kim, Andrew N. Leonard, Winnie W. Leung, Jordan J. Lucas, Susan A. Ludmann, Blair M. Lyons, Haseeb Malik, Ryan McGregor, Gabe E. Medrash, Sean L. Meharry, Kevin Mitcham, Irina A. Mueller, Timothy L. Murphy-Stevens, Aditya Nath, Angelique M. Nelson, Luana Paleologu, T. Alexander Popiel, Megan M. Riel-Mehan, Brock Roberts, Lisa M. Schaefbauer, Magdalena Schwarzl, Jamie Sherman, Sylvain Slaton, M. Filip Sluzewski, Jacqueline E. Smith, Youngmee Sul, Madison J. Swain-Bowden, W. Joyce Tang, Derek J. Thirstrup, Daniel M. Toloudis, Andrew P. Tucker, Veronica Valencia, Winfried Wiegraebe, Thushara Wijeratna, Ruian Yang, Rebecca J. Zaunbrecher, Allen Institute for Cell Science, Graham T. Johnson, Ruwanthi N. Gunawardane, Nathalie Gaudreault, Julie A. Theriot, Susanne M. Rafelski
doi: https://doi.org/10.1101/2020.12.08.415562
Matheus P. Viana
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Jianxu Chen
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Theo A. Knijnenburg
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Ritvik Vasan
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Calysta Yan
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Joy E. Arakaki
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Matte Bailey
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Ben Berry
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Antoine Borensztejn
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Jackson M. Brown
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Sara Carlson
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Julie A. Cass
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Basudev Chaudhuri
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Kimberly R. Cordes Metzler
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Mackenzie E. Coston
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Zach J. Crabtree
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Steve Davidson
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Colette M. DeLizo
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Shailja Dhaka
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Stephanie Q. Dinh
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Thao P. Do
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Justin Domingus
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Rory M. Donovan-Maiye
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Tyler J. Foster
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Christopher L. Frick
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Griffin Fujioka
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Margaret A. Fuqua
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Jamie L. Gehring
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Kaytlyn A. Gerbin
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Tanya Grancharova
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Benjamin W. Gregor
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Lisa J. Harrylock
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Amanda Haupt
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Melissa C. Hendershott
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Caroline Hookway
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Alan R. Horwitz
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Chris Hughes
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Eric J. Isaac
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Gregory R. Johnson
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Brian Kim
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Andrew N. Leonard
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Winnie W. Leung
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Jordan J. Lucas
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Susan A. Ludmann
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Blair M. Lyons
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Haseeb Malik
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Ryan McGregor
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Gabe E. Medrash
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Sean L. Meharry
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Kevin Mitcham
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Irina A. Mueller
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Timothy L. Murphy-Stevens
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Aditya Nath
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Angelique M. Nelson
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Luana Paleologu
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
T. Alexander Popiel
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Megan M. Riel-Mehan
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Brock Roberts
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Lisa M. Schaefbauer
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Magdalena Schwarzl
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Jamie Sherman
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Sylvain Slaton
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
M. Filip Sluzewski
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Jacqueline E. Smith
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Youngmee Sul
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Madison J. Swain-Bowden
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
W. Joyce Tang
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Derek J. Thirstrup
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Daniel M. Toloudis
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Andrew P. Tucker
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Veronica Valencia
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Winfried Wiegraebe
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Thushara Wijeratna
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Ruian Yang
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Rebecca J. Zaunbrecher
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Graham T. Johnson
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Ruwanthi N. Gunawardane
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Nathalie Gaudreault
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Julie A. Theriot
2Department of Biology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195
Susanne M. Rafelski
4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
Article Information
History
- January 13, 2021.
Article Versions
- Version 1 (December 10, 2020 - 06:27).
- You are viewing Version 2, the most recent version of this article.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Author Information
- Matheus P. Viana4,
- Jianxu Chen1,4,
- Theo A. Knijnenburg1,4,
- Ritvik Vasan1,4,
- Calysta Yan1,4,
- Joy E. Arakaki4,
- Matte Bailey4,
- Ben Berry4,
- Antoine Borensztejn4,
- Jackson M. Brown4,
- Sara Carlson4,
- Julie A. Cass4,
- Basudev Chaudhuri4,
- Kimberly R. Cordes Metzler4,
- Mackenzie E. Coston4,
- Zach J. Crabtree4,
- Steve Davidson4,
- Colette M. DeLizo4,
- Shailja Dhaka4,
- Stephanie Q. Dinh4,
- Thao P. Do4,
- Justin Domingus4,
- Rory M. Donovan-Maiye4,
- Tyler J. Foster4,
- Christopher L. Frick4,
- Griffin Fujioka4,
- Margaret A. Fuqua4,
- Jamie L. Gehring4,
- Kaytlyn A. Gerbin4,
- Tanya Grancharova4,
- Benjamin W. Gregor4,
- Lisa J. Harrylock4,
- Amanda Haupt4,
- Melissa C. Hendershott4,
- Caroline Hookway4,
- Alan R. Horwitz4,
- Chris Hughes4,
- Eric J. Isaac4,
- Gregory R. Johnson4,
- Brian Kim4,
- Andrew N. Leonard4,
- Winnie W. Leung4,
- Jordan J. Lucas4,
- Susan A. Ludmann4,
- Blair M. Lyons4,
- Haseeb Malik4,
- Ryan McGregor4,
- Gabe E. Medrash4,
- Sean L. Meharry4,
- Kevin Mitcham4,
- Irina A. Mueller4,
- Timothy L. Murphy-Stevens4,
- Aditya Nath4,
- Angelique M. Nelson4,
- Luana Paleologu4,
- T. Alexander Popiel4,
- Megan M. Riel-Mehan4,
- Brock Roberts4,
- Lisa M. Schaefbauer4,
- Magdalena Schwarzl4,
- Jamie Sherman4,
- Sylvain Slaton4,
- M. Filip Sluzewski4,
- Jacqueline E. Smith4,
- Youngmee Sul4,
- Madison J. Swain-Bowden4,
- W. Joyce Tang4,
- Derek J. Thirstrup4,
- Daniel M. Toloudis4,
- Andrew P. Tucker4,
- Veronica Valencia4,
- Winfried Wiegraebe4,
- Thushara Wijeratna4,
- Ruian Yang4,
- Rebecca J. Zaunbrecher4,
- Allen Institute for Cell Science,
- Graham T. Johnson4,
- Ruwanthi N. Gunawardane4,
- Nathalie Gaudreault4,
- Julie A. Theriot2 and
- Susanne M. Rafelski4,3
- 2Department of Biology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195
- 4Allen Institute for Cell Science, 615 Westlake Ave N, Seattle, WA, 98125, USA
- ↵3For correspondence: susanner{at}alleninstitute.org
↵1 These authors contributed equally
Posted January 13, 2021.
Robust integrated intracellular organization of the human iPS cell: where, how much, and how variable
Matheus P. Viana, Jianxu Chen, Theo A. Knijnenburg, Ritvik Vasan, Calysta Yan, Joy E. Arakaki, Matte Bailey, Ben Berry, Antoine Borensztejn, Jackson M. Brown, Sara Carlson, Julie A. Cass, Basudev Chaudhuri, Kimberly R. Cordes Metzler, Mackenzie E. Coston, Zach J. Crabtree, Steve Davidson, Colette M. DeLizo, Shailja Dhaka, Stephanie Q. Dinh, Thao P. Do, Justin Domingus, Rory M. Donovan-Maiye, Tyler J. Foster, Christopher L. Frick, Griffin Fujioka, Margaret A. Fuqua, Jamie L. Gehring, Kaytlyn A. Gerbin, Tanya Grancharova, Benjamin W. Gregor, Lisa J. Harrylock, Amanda Haupt, Melissa C. Hendershott, Caroline Hookway, Alan R. Horwitz, Chris Hughes, Eric J. Isaac, Gregory R. Johnson, Brian Kim, Andrew N. Leonard, Winnie W. Leung, Jordan J. Lucas, Susan A. Ludmann, Blair M. Lyons, Haseeb Malik, Ryan McGregor, Gabe E. Medrash, Sean L. Meharry, Kevin Mitcham, Irina A. Mueller, Timothy L. Murphy-Stevens, Aditya Nath, Angelique M. Nelson, Luana Paleologu, T. Alexander Popiel, Megan M. Riel-Mehan, Brock Roberts, Lisa M. Schaefbauer, Magdalena Schwarzl, Jamie Sherman, Sylvain Slaton, M. Filip Sluzewski, Jacqueline E. Smith, Youngmee Sul, Madison J. Swain-Bowden, W. Joyce Tang, Derek J. Thirstrup, Daniel M. Toloudis, Andrew P. Tucker, Veronica Valencia, Winfried Wiegraebe, Thushara Wijeratna, Ruian Yang, Rebecca J. Zaunbrecher, Allen Institute for Cell Science, Graham T. Johnson, Ruwanthi N. Gunawardane, Nathalie Gaudreault, Julie A. Theriot, Susanne M. Rafelski
bioRxiv 2020.12.08.415562; doi: https://doi.org/10.1101/2020.12.08.415562
Robust integrated intracellular organization of the human iPS cell: where, how much, and how variable
Matheus P. Viana, Jianxu Chen, Theo A. Knijnenburg, Ritvik Vasan, Calysta Yan, Joy E. Arakaki, Matte Bailey, Ben Berry, Antoine Borensztejn, Jackson M. Brown, Sara Carlson, Julie A. Cass, Basudev Chaudhuri, Kimberly R. Cordes Metzler, Mackenzie E. Coston, Zach J. Crabtree, Steve Davidson, Colette M. DeLizo, Shailja Dhaka, Stephanie Q. Dinh, Thao P. Do, Justin Domingus, Rory M. Donovan-Maiye, Tyler J. Foster, Christopher L. Frick, Griffin Fujioka, Margaret A. Fuqua, Jamie L. Gehring, Kaytlyn A. Gerbin, Tanya Grancharova, Benjamin W. Gregor, Lisa J. Harrylock, Amanda Haupt, Melissa C. Hendershott, Caroline Hookway, Alan R. Horwitz, Chris Hughes, Eric J. Isaac, Gregory R. Johnson, Brian Kim, Andrew N. Leonard, Winnie W. Leung, Jordan J. Lucas, Susan A. Ludmann, Blair M. Lyons, Haseeb Malik, Ryan McGregor, Gabe E. Medrash, Sean L. Meharry, Kevin Mitcham, Irina A. Mueller, Timothy L. Murphy-Stevens, Aditya Nath, Angelique M. Nelson, Luana Paleologu, T. Alexander Popiel, Megan M. Riel-Mehan, Brock Roberts, Lisa M. Schaefbauer, Magdalena Schwarzl, Jamie Sherman, Sylvain Slaton, M. Filip Sluzewski, Jacqueline E. Smith, Youngmee Sul, Madison J. Swain-Bowden, W. Joyce Tang, Derek J. Thirstrup, Daniel M. Toloudis, Andrew P. Tucker, Veronica Valencia, Winfried Wiegraebe, Thushara Wijeratna, Ruian Yang, Rebecca J. Zaunbrecher, Allen Institute for Cell Science, Graham T. Johnson, Ruwanthi N. Gunawardane, Nathalie Gaudreault, Julie A. Theriot, Susanne M. Rafelski
bioRxiv 2020.12.08.415562; doi: https://doi.org/10.1101/2020.12.08.415562
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