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Moment-by-moment tracking of naturalistic learning and its underlying hippocampo-cortical interactions

View ORCID ProfileSebastian Michelmann, Amy R. Price, Bobbi Aubrey, Werner K. Doyle, View ORCID ProfileDaniel Friedman, Patricia C. Dugan, Orrin Devinsky, Sasha Devore, Adeen Flinker, Uri Hasson, Kenneth A. Norman
doi: https://doi.org/10.1101/2020.12.09.416438
Sebastian Michelmann
1Department of Psychology, Princeton University, Princeton, NJ, USA
2Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA
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  • ORCID record for Sebastian Michelmann
  • For correspondence: s.michelmann@princeton.edu
Amy R. Price
1Department of Psychology, Princeton University, Princeton, NJ, USA
2Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA
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Bobbi Aubrey
1Department of Psychology, Princeton University, Princeton, NJ, USA
2Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA
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Werner K. Doyle
3School of Medicine, New York University, New York, NY, USA
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Daniel Friedman
3School of Medicine, New York University, New York, NY, USA
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Patricia C. Dugan
3School of Medicine, New York University, New York, NY, USA
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Orrin Devinsky
3School of Medicine, New York University, New York, NY, USA
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Sasha Devore
3School of Medicine, New York University, New York, NY, USA
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Adeen Flinker
3School of Medicine, New York University, New York, NY, USA
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Uri Hasson
1Department of Psychology, Princeton University, Princeton, NJ, USA
2Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA
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Kenneth A. Norman
1Department of Psychology, Princeton University, Princeton, NJ, USA
2Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA
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Abstract

Every day our memory system achieves a remarkable feat: We form lasting memories of stimuli that were only encountered once. Here we investigate such learning as it naturally occurs during story listening, with the goal of uncovering when and how memories are stored and retrieved during processing of continuous, naturalistic stimuli. In behavioral experiments we confirm that, after a single exposure to a naturalistic story, participants can learn about its structure and are able to recall upcoming words in the story. In patients undergoing electrocorticographic recordings, we then track mnemonic information in high frequency activity (70 – 200Hz) as patients listen to a story twice. In auditory processing regions we demonstrate the rapid reinstatement of upcoming information after a single exposure; this neural measure of predictive recall correlates with behavioral measures of event segmentation and learning. Connectivity analyses on the neural data reveal information-flow from cortex to hippocampus at the end of events. On the second time of listening information-flow from hippocampus to cortex precedes moments of successful reinstatement.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted December 09, 2020.
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Moment-by-moment tracking of naturalistic learning and its underlying hippocampo-cortical interactions
Sebastian Michelmann, Amy R. Price, Bobbi Aubrey, Werner K. Doyle, Daniel Friedman, Patricia C. Dugan, Orrin Devinsky, Sasha Devore, Adeen Flinker, Uri Hasson, Kenneth A. Norman
bioRxiv 2020.12.09.416438; doi: https://doi.org/10.1101/2020.12.09.416438
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Moment-by-moment tracking of naturalistic learning and its underlying hippocampo-cortical interactions
Sebastian Michelmann, Amy R. Price, Bobbi Aubrey, Werner K. Doyle, Daniel Friedman, Patricia C. Dugan, Orrin Devinsky, Sasha Devore, Adeen Flinker, Uri Hasson, Kenneth A. Norman
bioRxiv 2020.12.09.416438; doi: https://doi.org/10.1101/2020.12.09.416438

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