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Linear summation of metabotropic postsynaptic potentials follows coactivation of neurogliaform interneurons

View ORCID ProfileAttila Ozsvár, Gergely Komlósi, Gáspár Oláh, Judith Baka, Gábor Molnár, Gábor Tamás
doi: https://doi.org/10.1101/2020.12.10.418913
Attila Ozsvár
1MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, 52 Közép fasor, Szeged 6726, Hungary
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  • ORCID record for Attila Ozsvár
Gergely Komlósi
1MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, 52 Közép fasor, Szeged 6726, Hungary
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Gáspár Oláh
1MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, 52 Közép fasor, Szeged 6726, Hungary
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Judith Baka
1MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, 52 Közép fasor, Szeged 6726, Hungary
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Gábor Molnár
1MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, 52 Közép fasor, Szeged 6726, Hungary
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Gábor Tamás
1MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, 52 Közép fasor, Szeged 6726, Hungary
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  • For correspondence: gtamas@bio.u-szeged.hu
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Summary

Summation of ionotropic receptor-mediated responses is critical in neuronal computation by shaping input-output characteristics of neurons. However, arithmetics of summation for metabotropic signals are not known. We characterized the combined ionotropic and metabotropic output of neocortical neurogliaform cells (NGFCs) using electrophysiological and anatomical methods. These experiments revealed that GABA receptors are activated up to 1.8 microns from release sites and confirmed coactivation of putative NGFCs in superficial cortical layers in vivo. Triple recordings from presynaptic NGFCs converging to a postsynaptic neuron revealed sublinear summation of ionotropic GABAA responses and linear summation of metabotropic GABAB responses. Based on a model combining distances of volume transmission from release sites and distributions of all NGFC axon terminals, we postulate that 2 to 3 NGFCs provide input to a point in the neuropil. We suggest that interactions of metabotropic GABAergic responses remain linear even if most superficial layer interneurons specialized to recruit GABAB receptors are simultaneously active.

Competing Interest Statement

The authors have declared no competing interest.

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Posted December 11, 2020.
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Linear summation of metabotropic postsynaptic potentials follows coactivation of neurogliaform interneurons
Attila Ozsvár, Gergely Komlósi, Gáspár Oláh, Judith Baka, Gábor Molnár, Gábor Tamás
bioRxiv 2020.12.10.418913; doi: https://doi.org/10.1101/2020.12.10.418913
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Linear summation of metabotropic postsynaptic potentials follows coactivation of neurogliaform interneurons
Attila Ozsvár, Gergely Komlósi, Gáspár Oláh, Judith Baka, Gábor Molnár, Gábor Tamás
bioRxiv 2020.12.10.418913; doi: https://doi.org/10.1101/2020.12.10.418913

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