Cancer-Associated Mutations Perturb the Structure and Interactions of the Intrinsically Disordered p53 Transactivation Domain

Lynn G. Schrag; Indhujah Thevarajan; Xiaorong Liu; Om Prakash; Michal Zolkiewski; Jianhan Chen

doi:10.1101/2020.12.12.422504

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Cancer-Associated Mutations Perturb the Structure and Interactions of the Intrinsically Disordered p53 Transactivation Domain

Lynn G. Schrag, Indhujah Thevarajan, Xiaorong Liu, Om Prakash, Michal Zolkiewski, Jianhan Chen

doi: https://doi.org/10.1101/2020.12.12.422504

Lynn G. Schrag

1Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66505, USA

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Indhujah Thevarajan

1Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66505, USA

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Xiaorong Liu

2Department of Chemistry, University of Massachusetts Amherst, Amherst, MA 01003, USA

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Om Prakash

1Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66505, USA

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For correspondence: omp@ksu.edu michalz@ksu.edu jianhanc@umass.edu

Michal Zolkiewski

1Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66505, USA

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For correspondence: omp@ksu.edu michalz@ksu.edu jianhanc@umass.edu

Jianhan Chen

2Department of Chemistry, University of Massachusetts Amherst, Amherst, MA 01003, USA

3Department of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, MA 01003, USA

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For correspondence: omp@ksu.edu michalz@ksu.edu jianhanc@umass.edu

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Cancer-Associated Mutations Perturb the Structure and Interactions of the Intrinsically Disordered p53 Transactivation Domain

Lynn G. Schrag, Indhujah Thevarajan, Xiaorong Liu, Om Prakash, Michal Zolkiewski, Jianhan Chen

bioRxiv 2020.12.12.422504; doi: https://doi.org/10.1101/2020.12.12.422504

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Cancer-Associated Mutations Perturb the Structure and Interactions of the Intrinsically Disordered p53 Transactivation Domain

Lynn G. Schrag, Indhujah Thevarajan, Xiaorong Liu, Om Prakash, Michal Zolkiewski, Jianhan Chen

bioRxiv 2020.12.12.422504; doi: https://doi.org/10.1101/2020.12.12.422504

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