Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Intraventricular hemodynamics in pediatric patients with single right ventricles reveal deteriorated washout and low vortex formation times: An in silico study

Anna Grünwald, Jana Korte, Nadja Wilmanns, Christian Winkler, Katharina Linden, Ulrike Herberg, Sascha Groß-Hardt, Ulrich Steinseifer, Michael Neidlin
doi: https://doi.org/10.1101/2020.12.13.422573
Anna Grünwald
1Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute Aachen, RWTH Aachen University
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jana Korte
1Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute Aachen, RWTH Aachen University
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nadja Wilmanns
1Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute Aachen, RWTH Aachen University
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christian Winkler
2Department of Pediatric Cardiology, University Hospital of Bonn, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Katharina Linden
2Department of Pediatric Cardiology, University Hospital of Bonn, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ulrike Herberg
2Department of Pediatric Cardiology, University Hospital of Bonn, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sascha Groß-Hardt
1Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute Aachen, RWTH Aachen University
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ulrich Steinseifer
1Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute Aachen, RWTH Aachen University
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael Neidlin
1Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute Aachen, RWTH Aachen University
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: neidlin@ame.rwth-aachen.de
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

The congenital heart disease univentricular heart (UVH) occurs with an incidence of 0.04-0.5% in newborns and is often treated with the Fontan procedure. In this intervention, the cardiac circulation is transformed into a singular circulation with only one ventricular chamber pumping.

Hemodynamics the singular ventricle is a major research topic in cardiology and there exists a relationship between fluid dynamical features and cardiac behavior in health and disease. By visualizing the flow using Computational Fluid Dynamics (CFD) models, an option is created to investigate the flow in patient-specific geometries.

CFD simulation of the pathological single right ventricle in contrast to the healthy left ventricle is the research object of the present work. The aim is the numerical comparison of the intraventricular flow within the ventricles. Based on this, flow formation in different anatomies of the ventricles is investigated.

Patient-specific measurements of ventricles from three-dimensional real-time echocardiographic images served as the basis for the simulations with five single right ventricle (SRV) patients and two subjects with healthy left hearts (LV) investigated. Interpolation of these data reproduced the shape and continuous motion of the heart during a cardiac cycle. This motion was implemented into a CFD model with a moving mesh methodology. For comparison of the ventricles, the vortex formation as well as the occurring turbulent kinetic energy (TKE) and washout were evaluated. Vortex formation was assessed using the dimensionless vortex formation time (VFT).

The results show significantly lower values for the VFT and the TKE in SRV patients than for the compared LV Patients. Furthermore, vortex formation does not progress to the apex in SRV patients. These findings were confirmed by a significantly lower washout in SRV patients.

Flow simulation within the moving ventricle provides the possibility of more detailed analysis of the ventricular function. Simulation results show altered vortex formation and reduced washout of SRV in comparison to healthy LV. This information could provide important information for the planning and treatment of Fontan patients.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted December 13, 2020.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Intraventricular hemodynamics in pediatric patients with single right ventricles reveal deteriorated washout and low vortex formation times: An in silico study
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Intraventricular hemodynamics in pediatric patients with single right ventricles reveal deteriorated washout and low vortex formation times: An in silico study
Anna Grünwald, Jana Korte, Nadja Wilmanns, Christian Winkler, Katharina Linden, Ulrike Herberg, Sascha Groß-Hardt, Ulrich Steinseifer, Michael Neidlin
bioRxiv 2020.12.13.422573; doi: https://doi.org/10.1101/2020.12.13.422573
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Intraventricular hemodynamics in pediatric patients with single right ventricles reveal deteriorated washout and low vortex formation times: An in silico study
Anna Grünwald, Jana Korte, Nadja Wilmanns, Christian Winkler, Katharina Linden, Ulrike Herberg, Sascha Groß-Hardt, Ulrich Steinseifer, Michael Neidlin
bioRxiv 2020.12.13.422573; doi: https://doi.org/10.1101/2020.12.13.422573

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Bioengineering
Subject Areas
All Articles
  • Animal Behavior and Cognition (4665)
  • Biochemistry (10324)
  • Bioengineering (7649)
  • Bioinformatics (26269)
  • Biophysics (13487)
  • Cancer Biology (10656)
  • Cell Biology (15385)
  • Clinical Trials (138)
  • Developmental Biology (8474)
  • Ecology (12789)
  • Epidemiology (2067)
  • Evolutionary Biology (16810)
  • Genetics (11375)
  • Genomics (15441)
  • Immunology (10589)
  • Microbiology (25111)
  • Molecular Biology (10182)
  • Neuroscience (54283)
  • Paleontology (399)
  • Pathology (1663)
  • Pharmacology and Toxicology (2885)
  • Physiology (4329)
  • Plant Biology (9218)
  • Scientific Communication and Education (1584)
  • Synthetic Biology (2548)
  • Systems Biology (6766)
  • Zoology (1459)