Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Recurrent emergence and transmission of a SARS-CoV-2 Spike deletion ΔH69/V70

View ORCID ProfileSA Kemp, RP Datir, DA Collier, IATM Ferreira, A Carabelli, W Harvey, DL Robertson, View ORCID ProfileRK Gupta
doi: https://doi.org/10.1101/2020.12.14.422555
SA Kemp
1Division of Infection and Immunity, University College London, London, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for SA Kemp
RP Datir
1Division of Infection and Immunity, University College London, London, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DA Collier
1Division of Infection and Immunity, University College London, London, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
IATM Ferreira
2Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK
3Department of Medicine, University of Cambridge, Cambridge, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A Carabelli
3Department of Medicine, University of Cambridge, Cambridge, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
W Harvey
5Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DL Robertson
4MRC - University of Glasgow Centre for Virus Research, Glasgow, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
RK Gupta
2Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK
3Department of Medicine, University of Cambridge, Cambridge, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for RK Gupta
  • For correspondence: rkg20@cam.ac.uk
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

SARS-CoV-2 Spike amino acid replacements occur relatively frequently in the receptor binding domain (RBD) and some have a consequences for immune recognition. Here we report recurrent emergence and significant onward transmission of a six nucleotide deletion in the Spike gene, which results in the loss of two amino acids: ΔH69/V70. Of particular note this deletion often follows the receptor binding motif amino acid replacements N501Y, N439K and Y453F. In addition, we report a sub-lineage of over 350 sequences bearing seven spike mutations across the RBD (N501Y, A570D), S1 (ΔH69/V70) and S2 (P681H, T716I, S982A and D1118H) in England. These mutations have possibly arisen as a result of the virus evolving from immune selection pressure in infected individuals. Enhanced surveillance for the ΔH69/V70 deletion with and without RBD mutations should be considered as a priority.

Competing Interest Statement

RKG has received consulting fees from UMOVIS lab, Gilead Sciences and ViiV Healthcare, and a research grant from InvisiSmart Technologies.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
Back to top
PreviousNext
Posted December 14, 2020.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Recurrent emergence and transmission of a SARS-CoV-2 Spike deletion ΔH69/V70
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Recurrent emergence and transmission of a SARS-CoV-2 Spike deletion ΔH69/V70
SA Kemp, RP Datir, DA Collier, IATM Ferreira, A Carabelli, W Harvey, DL Robertson, RK Gupta
bioRxiv 2020.12.14.422555; doi: https://doi.org/10.1101/2020.12.14.422555
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
Recurrent emergence and transmission of a SARS-CoV-2 Spike deletion ΔH69/V70
SA Kemp, RP Datir, DA Collier, IATM Ferreira, A Carabelli, W Harvey, DL Robertson, RK Gupta
bioRxiv 2020.12.14.422555; doi: https://doi.org/10.1101/2020.12.14.422555

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Microbiology
Subject Areas
All Articles
  • Animal Behavior and Cognition (2530)
  • Biochemistry (4972)
  • Bioengineering (3482)
  • Bioinformatics (15212)
  • Biophysics (6897)
  • Cancer Biology (5390)
  • Cell Biology (7738)
  • Clinical Trials (138)
  • Developmental Biology (4530)
  • Ecology (7147)
  • Epidemiology (2059)
  • Evolutionary Biology (10227)
  • Genetics (7512)
  • Genomics (9786)
  • Immunology (4844)
  • Microbiology (13215)
  • Molecular Biology (5138)
  • Neuroscience (29435)
  • Paleontology (203)
  • Pathology (837)
  • Pharmacology and Toxicology (1463)
  • Physiology (2138)
  • Plant Biology (4748)
  • Scientific Communication and Education (1013)
  • Synthetic Biology (1338)
  • Systems Biology (4012)
  • Zoology (768)