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Neurophysiological correlates of residual inhibition in tinnitus: Hints for trait-like EEG power spectra

View ORCID ProfileS. Schoisswohl, View ORCID ProfileM. Schecklmann, View ORCID ProfileB. Langguth, View ORCID ProfileW. Schlee, View ORCID ProfileP. Neff
doi: https://doi.org/10.1101/2020.12.15.422892
S. Schoisswohl
1Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany
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  • For correspondence: stefanschoisswohl@yahoo.de
M. Schecklmann
1Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany
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B. Langguth
1Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany
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W. Schlee
1Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany
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P. Neff
1Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany
2University Research Priority Program ‘Dynamics of Healthy Aging’, University of Zurich, Zurich, Switzerland
3Center for Cognitive Neuroscience, University of Salzburg, Austria
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Abstract

Magneto- and electroencephalography (M/EEG) investigations in tinnitus patients demonstrated anomalous oscillatory brain activity patterns compared to healthy controls. A well-established phenomenon in tinnitus is the possibility to temporary suppress tinnitus following acoustic stimulation, which is termed residual inhibition (RI). The few former neurophysiological investigations of RI reported partly conflicting results hampering consensus on tinnitus-specific brain activity and basic neural models.

Hence, our objective was to investigate RI-specific oscillatory brain activity changes and whether these changes can be associated with behavioral measures of tinnitus loudness. Further, contrasts between acoustic stimulation responders and non-responders provide further insights in RI-related spontaneous brain activity.

Three different types of noise stimuli were administered for acoustic stimulation in 45 tinnitus patients. Subjects resting state brain activity was recorded before and during RI via EEG alongside with subjective measurements of tinnitus loudness.

On the whole-group level, tinnitus-unspecific changes were observed which fit established knowledge about basic neural responses after acoustic stimulation. Responder non-responder contrasts revealed differences in alpha and gamma band activity in line with the proposed neural models for oscillatory brain activity in tinnitus. Further analysis of sample characteristics demonstrated divergences between responders and non-responders notably for tinnitus duration. During RI, distinct differences between responders and non-responders were exclusively observed for alpha band activity in auditory cortical areas. Neither correlations of behavioral tinnitus measures nor differences between stimulus-induced changes in ongoing brain activity could be detected.

Taken together, our observations might be indicative of trait-specific forms of oscillatory signatures in different subsets and chronification grades of the tinnitus population possibly related to acoustic tinnitus suppression. Results and insights are not only useful to understand basic neural mechanisms behind RI but are also valuable for general neural models of tinnitus.

Highlights

  • Residual inhibition provides a key method to study the basic mechanisms of tinnitus.

  • We compared residual inhibition EEG activity between responders and non-responders.

  • In responders, the alpha activity in auditory areas was increased during tinnitus suppression.

  • Results and insights are valuable for understanding the neural mechanisms behind acoustic tinnitus suppression.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted December 16, 2020.
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Neurophysiological correlates of residual inhibition in tinnitus: Hints for trait-like EEG power spectra
S. Schoisswohl, M. Schecklmann, B. Langguth, W. Schlee, P. Neff
bioRxiv 2020.12.15.422892; doi: https://doi.org/10.1101/2020.12.15.422892
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Neurophysiological correlates of residual inhibition in tinnitus: Hints for trait-like EEG power spectra
S. Schoisswohl, M. Schecklmann, B. Langguth, W. Schlee, P. Neff
bioRxiv 2020.12.15.422892; doi: https://doi.org/10.1101/2020.12.15.422892

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