Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Activity flow underlying abnormalities in brain activations and cognition in schizophrenia

View ORCID ProfileLuke J. Hearne, Ravi D. Mill, Brian P. Keane, Grega Repovš, Alan Anticevic, Michael W. Cole
doi: https://doi.org/10.1101/2020.12.16.423109
Luke J. Hearne
1Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Luke J. Hearne
  • For correspondence: lukehearne@gmail.com
Ravi D. Mill
1Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Brian P. Keane
1Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ
2University of Rochester, Departments of Neuroscience and Psychiatry, Rochester, NY
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Grega Repovš
3Department of Psychology, University of Ljubljana, Aškerčeva 2, Ljubljana SI-1000, Slovenia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alan Anticevic
4Department of Psychiatry, Yale University School of Medicine, New Haven, CT
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael W. Cole
1Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Cognitive dysfunction is a core feature of many brain disorders such as schizophrenia (SZ), and has been linked to both aberrant brain functional connectivity (FC) and aberrant cognitive brain activations. We propose that aberrant network activity flow over FC pathways leads to altered cognitive activations that produce cognitive dysfunction in SZ. We tested this hypothesis using activity flow mapping – an approach that models the movement of task-related activity between brain regions as a function of FC. Using fMRI data from SZ individuals and healthy controls during a working memory task, we found that activity flow models accurately predict aberrant cognitive activations across multiple brain networks. Within the same framework, we simulated a connectivity-based clinical intervention, predicting specific treatments that normalized brain activations and behavior in independent patients. Our results suggest that dysfunctional task-evoked activity flow is a large-scale network mechanism contributing to the emergence of cognitive dysfunction in SZ.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Conflict of Interest: None

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
Back to top
PreviousNext
Posted December 18, 2020.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Activity flow underlying abnormalities in brain activations and cognition in schizophrenia
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Activity flow underlying abnormalities in brain activations and cognition in schizophrenia
Luke J. Hearne, Ravi D. Mill, Brian P. Keane, Grega Repovš, Alan Anticevic, Michael W. Cole
bioRxiv 2020.12.16.423109; doi: https://doi.org/10.1101/2020.12.16.423109
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Activity flow underlying abnormalities in brain activations and cognition in schizophrenia
Luke J. Hearne, Ravi D. Mill, Brian P. Keane, Grega Repovš, Alan Anticevic, Michael W. Cole
bioRxiv 2020.12.16.423109; doi: https://doi.org/10.1101/2020.12.16.423109

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (4369)
  • Biochemistry (9546)
  • Bioengineering (7068)
  • Bioinformatics (24768)
  • Biophysics (12560)
  • Cancer Biology (9924)
  • Cell Biology (14297)
  • Clinical Trials (138)
  • Developmental Biology (7930)
  • Ecology (12074)
  • Epidemiology (2067)
  • Evolutionary Biology (15954)
  • Genetics (10904)
  • Genomics (14706)
  • Immunology (9844)
  • Microbiology (23582)
  • Molecular Biology (9454)
  • Neuroscience (50691)
  • Paleontology (369)
  • Pathology (1535)
  • Pharmacology and Toxicology (2674)
  • Physiology (3997)
  • Plant Biology (8639)
  • Scientific Communication and Education (1505)
  • Synthetic Biology (2388)
  • Systems Biology (6415)
  • Zoology (1344)