Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Molecular diversity analysis of the spike glycoprotein (S) gene from Hong Kong - China

View ORCID ProfileEduarda Doralice Alves Braz Da Silva, View ORCID ProfileDallynne Bárbara Ramos Venâncio, View ORCID ProfileRosane Maria de Albuquerque, View ORCID ProfileRobson da Silva Ramos, View ORCID ProfilePierre Teodósio Felix
doi: https://doi.org/10.1101/2020.12.16.423166
Eduarda Doralice Alves Braz Da Silva
, Pernambuco, Brazil
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Eduarda Doralice Alves Braz Da Silva
Dallynne Bárbara Ramos Venâncio
, Pernambuco, Brazil
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Dallynne Bárbara Ramos Venâncio
Rosane Maria de Albuquerque
, Pernambuco, Brazil
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Rosane Maria de Albuquerque
Robson da Silva Ramos
, Pernambuco, Brazil
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Robson da Silva Ramos
Pierre Teodósio Felix
, Pernambuco, Brazil
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Pierre Teodósio Felix
  • For correspondence: pierrefelix@univisa.edu.br
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Data/Code
  • Preview PDF
Loading

Abstract

In this work, 37 haplotypes of spike glycoprotein of SARS-CoV-2 from Hong Kong, China, were used. All sequences were publicly available on the Platform of the National Center for Biotechnology Information (NCBI) and were analyzed for their Molecular Variance (AMOVA), haplotypic diversity, mismatch, demographic and spatial expansion, molecular diversity and time of evolutionary divergence. The results suggested that there was a low diversity among haplotypes, with very low numbers of transitions, transversions, indels-type mutations and with total absence of population expansion perceived in the neutrality tests. The estimators used in this study supported the uniformity among all the results found and confirm the evolutionary conservation of the gene, as well as its protein product, a fact that stimulates the use of therapies based on neutralizing antibodies, such as vaccines based on protein S.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • https://www.ncbi.nlm.nih.gov/popset/?term=89474483

  • https://dx.doi.org/10.17504/protocols.io.bmbvk2n6

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
Back to top
PreviousNext
Posted December 17, 2020.
Download PDF
Data/Code
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Molecular diversity analysis of the spike glycoprotein (S) gene from Hong Kong - China
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Molecular diversity analysis of the spike glycoprotein (S) gene from Hong Kong - China
Eduarda Doralice Alves Braz Da Silva, Dallynne Bárbara Ramos Venâncio, Rosane Maria de Albuquerque, Robson da Silva Ramos, Pierre Teodósio Felix
bioRxiv 2020.12.16.423166; doi: https://doi.org/10.1101/2020.12.16.423166
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Molecular diversity analysis of the spike glycoprotein (S) gene from Hong Kong - China
Eduarda Doralice Alves Braz Da Silva, Dallynne Bárbara Ramos Venâncio, Rosane Maria de Albuquerque, Robson da Silva Ramos, Pierre Teodósio Felix
bioRxiv 2020.12.16.423166; doi: https://doi.org/10.1101/2020.12.16.423166

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Bioinformatics
Subject Areas
All Articles
  • Animal Behavior and Cognition (3502)
  • Biochemistry (7343)
  • Bioengineering (5319)
  • Bioinformatics (20258)
  • Biophysics (10008)
  • Cancer Biology (7735)
  • Cell Biology (11293)
  • Clinical Trials (138)
  • Developmental Biology (6434)
  • Ecology (9947)
  • Epidemiology (2065)
  • Evolutionary Biology (13315)
  • Genetics (9359)
  • Genomics (12579)
  • Immunology (7696)
  • Microbiology (19008)
  • Molecular Biology (7437)
  • Neuroscience (41011)
  • Paleontology (300)
  • Pathology (1228)
  • Pharmacology and Toxicology (2134)
  • Physiology (3155)
  • Plant Biology (6858)
  • Scientific Communication and Education (1272)
  • Synthetic Biology (1895)
  • Systems Biology (5311)
  • Zoology (1087)