New Results
Furin cleaves SARS-CoV-2 spike-glycoprotein at S1/S2 and S2’ for viral fusion/entry: indirect role of TMPRSS2
Rachid Essalmani, Jaspreet Jain, View ORCID ProfileDelia Susan-Resiga, View ORCID ProfileUrsula Andréo, Alexandra Evagelidis, Rabeb Mouna Derbali, David N. Huynh, Frédéric Dallaire, Mélanie Laporte, Adrien Delpal, Priscila Sutto-Ortiz, View ORCID ProfileBruno Coutard, View ORCID ProfileClaudine Mapa, Keith Wilcoxen, View ORCID ProfileÉtienne Decroly, Tram NQ Pham, View ORCID ProfileÉric A. Cohen, View ORCID ProfileNabil G. Seidah
doi: https://doi.org/10.1101/2020.12.18.423106
Rachid Essalmani
1Laboratory of Biochemical Neuroendocrinology Montreal Clinical Research Institute (IRCM, affiliated to the University of Montreal) 110 Pine Ave west, Montreal, QC, H2W1R7, Canada
Jaspreet Jain
2Laboratory of Human Retrovirology Montreal Clinical Research Institute (IRCM, affiliated to the University of Montreal) 110 Pine Ave west, Montreal, QC, H2W1R7, Canada
Delia Susan-Resiga
1Laboratory of Biochemical Neuroendocrinology Montreal Clinical Research Institute (IRCM, affiliated to the University of Montreal) 110 Pine Ave west, Montreal, QC, H2W1R7, Canada
Ursula Andréo
1Laboratory of Biochemical Neuroendocrinology Montreal Clinical Research Institute (IRCM, affiliated to the University of Montreal) 110 Pine Ave west, Montreal, QC, H2W1R7, Canada
2Laboratory of Human Retrovirology Montreal Clinical Research Institute (IRCM, affiliated to the University of Montreal) 110 Pine Ave west, Montreal, QC, H2W1R7, Canada
Alexandra Evagelidis
1Laboratory of Biochemical Neuroendocrinology Montreal Clinical Research Institute (IRCM, affiliated to the University of Montreal) 110 Pine Ave west, Montreal, QC, H2W1R7, Canada
Rabeb Mouna Derbali
1Laboratory of Biochemical Neuroendocrinology Montreal Clinical Research Institute (IRCM, affiliated to the University of Montreal) 110 Pine Ave west, Montreal, QC, H2W1R7, Canada
David N. Huynh
1Laboratory of Biochemical Neuroendocrinology Montreal Clinical Research Institute (IRCM, affiliated to the University of Montreal) 110 Pine Ave west, Montreal, QC, H2W1R7, Canada
Frédéric Dallaire
2Laboratory of Human Retrovirology Montreal Clinical Research Institute (IRCM, affiliated to the University of Montreal) 110 Pine Ave west, Montreal, QC, H2W1R7, Canada
Mélanie Laporte
2Laboratory of Human Retrovirology Montreal Clinical Research Institute (IRCM, affiliated to the University of Montreal) 110 Pine Ave west, Montreal, QC, H2W1R7, Canada
Adrien Delpal
3AFMB, CNRS, Université Aix-Marseille, UMR 7257, Case 925, 163 Avenue de Luminy, 13288 Marseille Cedex 09, France, Marseille, France
Priscila Sutto-Ortiz
3AFMB, CNRS, Université Aix-Marseille, UMR 7257, Case 925, 163 Avenue de Luminy, 13288 Marseille Cedex 09, France, Marseille, France
Bruno Coutard
4Unité des Virus Émergents (UVE: Aix-Marseille Univ - IRD 190 - Inserm 1207 - IHU Méditerranée Infection), Marseille, France
Claudine Mapa
5Boston Pharmaceuticals, Translational Research, 55 Cambridge Parkway, Suite 400, Cambridge, MA 02142, USA
Keith Wilcoxen
5Boston Pharmaceuticals, Translational Research, 55 Cambridge Parkway, Suite 400, Cambridge, MA 02142, USA
Étienne Decroly
3AFMB, CNRS, Université Aix-Marseille, UMR 7257, Case 925, 163 Avenue de Luminy, 13288 Marseille Cedex 09, France, Marseille, France
Tram NQ Pham
2Laboratory of Human Retrovirology Montreal Clinical Research Institute (IRCM, affiliated to the University of Montreal) 110 Pine Ave west, Montreal, QC, H2W1R7, Canada
Éric A. Cohen
2Laboratory of Human Retrovirology Montreal Clinical Research Institute (IRCM, affiliated to the University of Montreal) 110 Pine Ave west, Montreal, QC, H2W1R7, Canada
Nabil G. Seidah
1Laboratory of Biochemical Neuroendocrinology Montreal Clinical Research Institute (IRCM, affiliated to the University of Montreal) 110 Pine Ave west, Montreal, QC, H2W1R7, Canada
Article usage
Posted December 20, 2020.
Furin cleaves SARS-CoV-2 spike-glycoprotein at S1/S2 and S2’ for viral fusion/entry: indirect role of TMPRSS2
Rachid Essalmani, Jaspreet Jain, Delia Susan-Resiga, Ursula Andréo, Alexandra Evagelidis, Rabeb Mouna Derbali, David N. Huynh, Frédéric Dallaire, Mélanie Laporte, Adrien Delpal, Priscila Sutto-Ortiz, Bruno Coutard, Claudine Mapa, Keith Wilcoxen, Étienne Decroly, Tram NQ Pham, Éric A. Cohen, Nabil G. Seidah
bioRxiv 2020.12.18.423106; doi: https://doi.org/10.1101/2020.12.18.423106
Furin cleaves SARS-CoV-2 spike-glycoprotein at S1/S2 and S2’ for viral fusion/entry: indirect role of TMPRSS2
Rachid Essalmani, Jaspreet Jain, Delia Susan-Resiga, Ursula Andréo, Alexandra Evagelidis, Rabeb Mouna Derbali, David N. Huynh, Frédéric Dallaire, Mélanie Laporte, Adrien Delpal, Priscila Sutto-Ortiz, Bruno Coutard, Claudine Mapa, Keith Wilcoxen, Étienne Decroly, Tram NQ Pham, Éric A. Cohen, Nabil G. Seidah
bioRxiv 2020.12.18.423106; doi: https://doi.org/10.1101/2020.12.18.423106
Subject Area
Subject Areas
- Biochemistry (11752)
- Bioengineering (8752)
- Bioinformatics (29200)
- Biophysics (14974)
- Cancer Biology (12096)
- Cell Biology (17411)
- Clinical Trials (138)
- Developmental Biology (9421)
- Ecology (14182)
- Epidemiology (2067)
- Evolutionary Biology (18308)
- Genetics (12245)
- Genomics (16803)
- Immunology (11869)
- Microbiology (28097)
- Molecular Biology (11594)
- Neuroscience (60969)
- Paleontology (451)
- Pathology (1871)
- Pharmacology and Toxicology (3238)
- Physiology (4959)
- Plant Biology (10427)
- Synthetic Biology (2886)
- Systems Biology (7340)
- Zoology (1651)