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Increased functional connectivity of the intraparietal sulcus underlies the attenuation of numerosity estimations for self-generated words

Giedre Stripeikyte, Michael Pereira, Giulio Rognini, Jevita Potheegadoo, Olaf Blanke, Nathan Faivre
doi: https://doi.org/10.1101/2020.12.18.423390
Giedre Stripeikyte
1Center for Neuroprosthetics, Swiss Federal Institute of Technology (EPFL), CH-1202 Geneva, Switzerland
2Brain Mind Institute, Faculty of Life Sciences, Swiss Federal Institute of Technology (EPFL), CH-1015 Lausanne, Switzerland
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Michael Pereira
1Center for Neuroprosthetics, Swiss Federal Institute of Technology (EPFL), CH-1202 Geneva, Switzerland
2Brain Mind Institute, Faculty of Life Sciences, Swiss Federal Institute of Technology (EPFL), CH-1015 Lausanne, Switzerland
3Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRS, LPNC, 38000 Grenoble, France
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Giulio Rognini
1Center for Neuroprosthetics, Swiss Federal Institute of Technology (EPFL), CH-1202 Geneva, Switzerland
2Brain Mind Institute, Faculty of Life Sciences, Swiss Federal Institute of Technology (EPFL), CH-1015 Lausanne, Switzerland
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Jevita Potheegadoo
1Center for Neuroprosthetics, Swiss Federal Institute of Technology (EPFL), CH-1202 Geneva, Switzerland
2Brain Mind Institute, Faculty of Life Sciences, Swiss Federal Institute of Technology (EPFL), CH-1015 Lausanne, Switzerland
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Olaf Blanke
1Center for Neuroprosthetics, Swiss Federal Institute of Technology (EPFL), CH-1202 Geneva, Switzerland
2Brain Mind Institute, Faculty of Life Sciences, Swiss Federal Institute of Technology (EPFL), CH-1015 Lausanne, Switzerland
4Department of Neurology, University of Geneva, CH-1211 Geneva, Switzerland
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  • For correspondence: olaf.blanke@epfl.ch nathan.faivre@univ-grenoble-alpes.fr
Nathan Faivre
1Center for Neuroprosthetics, Swiss Federal Institute of Technology (EPFL), CH-1202 Geneva, Switzerland
2Brain Mind Institute, Faculty of Life Sciences, Swiss Federal Institute of Technology (EPFL), CH-1015 Lausanne, Switzerland
3Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRS, LPNC, 38000 Grenoble, France
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  • For correspondence: olaf.blanke@epfl.ch nathan.faivre@univ-grenoble-alpes.fr
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ABSTRACT

Previous studies have shown that self-generated stimuli in auditory, visual, and somatosensory domains are attenuated, producing decreased behavioral and neural responses compared to the same stimuli that are externally generated. Yet, whether such attenuation also occurs for higher-level cognitive functions beyond sensorimotor processing remains unknown. In this study, we assessed whether cognitive functions such as numerosity estimations are subject to attenuation. We designed a task allowing the controlled comparison of numerosity estimations for self (active condition) and externally (passive condition) generated words. Our behavioral results showed a larger underestimation of self-compared to externally-generated words, suggesting that numerosity estimations for self-generated words are attenuated. Moreover, the linear relationship between the reported and actual number of words was stronger for self-generated words, although the ability to track errors about numerosity estimations was similar across conditions. Neuroimaging results revealed that numerosity underestimation involved increased functional connectivity between the right intraparietal sulcus and an extended network (bilateral supplementary motor area, left inferior parietal lobule and left superior temporal gyrus) when estimating the number of self vs. externally generated words. We interpret our results in light of two models of attenuation and discuss their perceptual versus cognitive origins.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Conflict of interest statement The authors declare no competing interests.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted December 20, 2020.
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Increased functional connectivity of the intraparietal sulcus underlies the attenuation of numerosity estimations for self-generated words
Giedre Stripeikyte, Michael Pereira, Giulio Rognini, Jevita Potheegadoo, Olaf Blanke, Nathan Faivre
bioRxiv 2020.12.18.423390; doi: https://doi.org/10.1101/2020.12.18.423390
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Increased functional connectivity of the intraparietal sulcus underlies the attenuation of numerosity estimations for self-generated words
Giedre Stripeikyte, Michael Pereira, Giulio Rognini, Jevita Potheegadoo, Olaf Blanke, Nathan Faivre
bioRxiv 2020.12.18.423390; doi: https://doi.org/10.1101/2020.12.18.423390

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