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Genetics of white color and iridophoroma in “Lemon Frost” leopard geckos

View ORCID ProfileLonghua Guo, View ORCID ProfileJoshua Bloom, Steve Sykes, Elaine Huang, Zain Kashif, Elise Pham, Katarina Ho, Ana Alcaraz, Xinshu Grace Xiao, Sandra Duarte-Vogel, View ORCID ProfileLeonid Kruglyak
doi: https://doi.org/10.1101/2020.12.18.423549
Longhua Guo
1Department of Human Genetics, Department of Biological Chemistry, Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095, USA
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  • For correspondence: longhuaguo@mednet.ucla.edu lkruglyak@mednet.ucla.edu
Joshua Bloom
1Department of Human Genetics, Department of Biological Chemistry, Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095, USA
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Steve Sykes
2Geckos Etc. Herpetoculture, Rocklin, CA 95765, USA
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Elaine Huang
3Department of Integrative Biology and Physiology, University of California, Los Angeles, CA 90095, USA
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Zain Kashif
1Department of Human Genetics, Department of Biological Chemistry, Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095, USA
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Elise Pham
1Department of Human Genetics, Department of Biological Chemistry, Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095, USA
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Katarina Ho
1Department of Human Genetics, Department of Biological Chemistry, Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095, USA
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Ana Alcaraz
4College of Veterinary Medicine, Western University of Health Sciences, Pomona, CA 91711, USA
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Xinshu Grace Xiao
3Department of Integrative Biology and Physiology, University of California, Los Angeles, CA 90095, USA
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Sandra Duarte-Vogel
5Division of Laboratory Animal Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
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Leonid Kruglyak
1Department of Human Genetics, Department of Biological Chemistry, Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095, USA
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  • ORCID record for Leonid Kruglyak
  • For correspondence: longhuaguo@mednet.ucla.edu lkruglyak@mednet.ucla.edu
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Abstract

The squamates (lizards and snakes) are close relatives of birds and mammals, with more than 10,000 described species that display extensive variation in a number of important biological traits, including coloration, venom production, and regeneration. Due to a lack of genomic tools, few genetic studies in squamates have been carried out. The leopard gecko1, Eublepharis macularius, is a popular companion animal, and displays a variety of coloration patterns. We took advantage of a large breeding colony and used linkage analysis, synteny, and homozygosity mapping to investigate a spontaneous semi-dominant mutation, “Lemon Frost”, that produces white coloration and causes skin tumors (iridophoroma). We localized the mutation to a single locus which contains a strong candidate gene, SPINT12,3, a tumor suppressor implicated in human skin cutaneous melanoma (SKCM) and over-proliferation of epithelial cells in mice and zebrafish4–16. Our work establishes the leopard gecko as a tractable genetic system and suggests that a tumor suppressor in melanocytes in humans can also suppress tumor development in iridophores in lizards.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted January 27, 2021.
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Genetics of white color and iridophoroma in “Lemon Frost” leopard geckos
Longhua Guo, Joshua Bloom, Steve Sykes, Elaine Huang, Zain Kashif, Elise Pham, Katarina Ho, Ana Alcaraz, Xinshu Grace Xiao, Sandra Duarte-Vogel, Leonid Kruglyak
bioRxiv 2020.12.18.423549; doi: https://doi.org/10.1101/2020.12.18.423549
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Genetics of white color and iridophoroma in “Lemon Frost” leopard geckos
Longhua Guo, Joshua Bloom, Steve Sykes, Elaine Huang, Zain Kashif, Elise Pham, Katarina Ho, Ana Alcaraz, Xinshu Grace Xiao, Sandra Duarte-Vogel, Leonid Kruglyak
bioRxiv 2020.12.18.423549; doi: https://doi.org/10.1101/2020.12.18.423549

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