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Cross-reactive coronavirus antibodies with diverse epitope specificities and extra-neutralization functions
Andrea R. Shiakolas, Kevin J. Kramer, Daniel Wrapp, Simone I. Richardson, Alexandra Schäfer, Steven Wall, Nianshuang Wang, Katarzyna Janowska, Kelsey A. Pilewski, Rohit Venkat, Rob Parks, Nelia P. Manamela, Nagarajan Raju, Emilee Friedman Fechter, Clinton M. Holt, Naveenchandra Suryadevara, Rita E. Chen, David R. Martinez, Rachel S. Nargi, Rachel E. Sutton, Julie E. Ledgerwood, View ORCID ProfileBarney S. Graham, Michael S. Diamond, Barton F. Haynes, Priyamvada Acharya, View ORCID ProfileRobert H. Carnahan, James E. Crowe Jr, Ralph S. Baric, Lynn Morris, Jason S. McLellan, Ivelin S. Georgiev
doi: https://doi.org/10.1101/2020.12.20.414748
Andrea R. Shiakolas
1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
2Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
Kevin J. Kramer
1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
2Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
Daniel Wrapp
3Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, 78712, USA
Simone I. Richardson
4National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg 2131, South Africa
Alexandra Schäfer
5Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27516, USA
Steven Wall
1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
Nianshuang Wang
3Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, 78712, USA
Katarzyna Janowska
6Division of Structural Biology, Duke University School of Medicine, Durham, NC, 27710, USA
Kelsey A. Pilewski
1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
2Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
Rohit Venkat
1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
7Program in Chemical and Physical Biology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
Rob Parks
8Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, 27710, USA
Nelia P. Manamela
4National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg 2131, South Africa
Nagarajan Raju
1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
2Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
Emilee Friedman Fechter
1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
Clinton M. Holt
1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
7Program in Chemical and Physical Biology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
Naveenchandra Suryadevara
1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
Rita E. Chen
9Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA
10Department of Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA
David R. Martinez
5Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27516, USA
Rachel S. Nargi
1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
Rachel E. Sutton
1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
Julie E. Ledgerwood
11Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA
Barney S. Graham
11Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA
Michael S. Diamond
9Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA
10Department of Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA
12Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, 63110, USA
Barton F. Haynes
8Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, 27710, USA
Priyamvada Acharya
6Division of Structural Biology, Duke University School of Medicine, Durham, NC, 27710, USA
8Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, 27710, USA
Robert H. Carnahan
1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
13Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
James E. Crowe Jr
1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
13Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
Ralph S. Baric
5Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27516, USA
Lynn Morris
4National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg 2131, South Africa
Jason S. McLellan
3Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, 78712, USA
Ivelin S. Georgiev
1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
2Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
14Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
15Department of Electrical Engineering and Computer Science, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
16Center for Structural Biology, Vanderbilt University, Nashville, TN, 37232, USA
17Program in Computational Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
Posted December 20, 2020.
Cross-reactive coronavirus antibodies with diverse epitope specificities and extra-neutralization functions
Andrea R. Shiakolas, Kevin J. Kramer, Daniel Wrapp, Simone I. Richardson, Alexandra Schäfer, Steven Wall, Nianshuang Wang, Katarzyna Janowska, Kelsey A. Pilewski, Rohit Venkat, Rob Parks, Nelia P. Manamela, Nagarajan Raju, Emilee Friedman Fechter, Clinton M. Holt, Naveenchandra Suryadevara, Rita E. Chen, David R. Martinez, Rachel S. Nargi, Rachel E. Sutton, Julie E. Ledgerwood, Barney S. Graham, Michael S. Diamond, Barton F. Haynes, Priyamvada Acharya, Robert H. Carnahan, James E. Crowe Jr, Ralph S. Baric, Lynn Morris, Jason S. McLellan, Ivelin S. Georgiev
bioRxiv 2020.12.20.414748; doi: https://doi.org/10.1101/2020.12.20.414748
Cross-reactive coronavirus antibodies with diverse epitope specificities and extra-neutralization functions
Andrea R. Shiakolas, Kevin J. Kramer, Daniel Wrapp, Simone I. Richardson, Alexandra Schäfer, Steven Wall, Nianshuang Wang, Katarzyna Janowska, Kelsey A. Pilewski, Rohit Venkat, Rob Parks, Nelia P. Manamela, Nagarajan Raju, Emilee Friedman Fechter, Clinton M. Holt, Naveenchandra Suryadevara, Rita E. Chen, David R. Martinez, Rachel S. Nargi, Rachel E. Sutton, Julie E. Ledgerwood, Barney S. Graham, Michael S. Diamond, Barton F. Haynes, Priyamvada Acharya, Robert H. Carnahan, James E. Crowe Jr, Ralph S. Baric, Lynn Morris, Jason S. McLellan, Ivelin S. Georgiev
bioRxiv 2020.12.20.414748; doi: https://doi.org/10.1101/2020.12.20.414748
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