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Cetylpyridinium chloride-containing mouthwashes reduce in vitro SARS-CoV-2 infectivity

Jordana Muñoz-Basagoiti, Daniel Perez-Zsolt, Rubén León, Vanessa Blanc, Joan Gispert, Bonaventura Clotet, View ORCID ProfileNuria Izquierdo-Useros
doi: https://doi.org/10.1101/2020.12.21.423779
Jordana Muñoz-Basagoiti
1IrsiCaixa AIDS Research Institute, 08916, Badalona, Spain
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Daniel Perez-Zsolt
1IrsiCaixa AIDS Research Institute, 08916, Badalona, Spain
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Rubén León
2Dentaid Research Center, 08290, Cerdanyola del Vallès, Spain
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Vanessa Blanc
2Dentaid Research Center, 08290, Cerdanyola del Vallès, Spain
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Joan Gispert
2Dentaid Research Center, 08290, Cerdanyola del Vallès, Spain
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Bonaventura Clotet
1IrsiCaixa AIDS Research Institute, 08916, Badalona, Spain
3Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, 08916, Badalona, Spain
4University of Vic–Central University of Catalonia (UVic-UCC), Vic, Spain
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Nuria Izquierdo-Useros
1IrsiCaixa AIDS Research Institute, 08916, Badalona, Spain
3Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, 08916, Badalona, Spain
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  • ORCID record for Nuria Izquierdo-Useros
  • For correspondence: nizquierdo@irsicaixa.es
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ABSTRACT

Oral mouthwashes decrease the infectivity of several respiratory viruses including SARS-CoV-2. However, the precise agents with antiviral activity present in these oral rinses and their exact mechanism of action remain unknown. Here we show that Cetylpyridinium chloride (CPC), a quaternary ammonium compound present in many oral mouthwashes, reduces SARS-CoV-2 infectivity by inhibiting viral fusion with target cells. We also found that CPC and CPC-containing mouth rinses decreased a thousand times the infectivity of SARS-CoV-2 in vitro, while the corresponding vehicles had no effect. CPC-containing mouth rinses could represent a cost-effective measure to reduce SARS-CoV-2 infectivity in saliva, aiding to reduce viral transmission from infected individuals.

Competing Interest Statement

This research was funded by Dentaid SL. R.L, VB. and J.G are researchers working for Dentaid Research Center. The authors declare that no other competing interest exist.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted December 21, 2020.
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Cetylpyridinium chloride-containing mouthwashes reduce in vitro SARS-CoV-2 infectivity
Jordana Muñoz-Basagoiti, Daniel Perez-Zsolt, Rubén León, Vanessa Blanc, Joan Gispert, Bonaventura Clotet, Nuria Izquierdo-Useros
bioRxiv 2020.12.21.423779; doi: https://doi.org/10.1101/2020.12.21.423779
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Cetylpyridinium chloride-containing mouthwashes reduce in vitro SARS-CoV-2 infectivity
Jordana Muñoz-Basagoiti, Daniel Perez-Zsolt, Rubén León, Vanessa Blanc, Joan Gispert, Bonaventura Clotet, Nuria Izquierdo-Useros
bioRxiv 2020.12.21.423779; doi: https://doi.org/10.1101/2020.12.21.423779

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