New Results
Rare coding variants in 35 genes associate with circulating lipid levels – a multi-ancestry analysis of 170,000 exomes
View ORCID ProfileGeorge Hindy, Peter Dornbos, Mark D. Chaffin, Dajiang J. Liu, Minxian Wang, Carlos A. Aguilar-Salinas, Lucinda Antonacci-Fulton, Diego Ardissino, Donna K. Arnett, Stella Aslibekyan, Gil Atzmon, Christie M. Ballantyne, Francisco Barajas-Olmos, Nir Barzilai, Lewis C. Becker, Lawrence F. Bielak, Joshua C. Bis, John Blangero, Eric Boerwinkle, Lori L. Bonnycastle, Erwin Bottinger, Donald W. Bowden, Matthew J. Bown, View ORCID ProfileJennifer A. Brody, Jai G. Broome, Noël P. Burtt, Brian E. Cade, Federico Centeno-Cruz, Edmund Chan, Yi-Cheng Chang, Yii-Der I. Chen, Ching-Yu Cheng, Won Jung Choi, Rajiv Chowdhury, Cecilia Contreras-Cubas, Emilio J. Córdova, Adolfo Correa, L Adrienne Cupples, Joanne E. Curran, John Danesh, Paul S. de Vries, Ralph A. DeFronzo, Harsha Doddapaneni, Ravindranath Duggirala, View ORCID ProfileSusan K. Dutcher, View ORCID ProfilePatrick T. Ellinor, Leslie S. Emery, Jose C. Florez, View ORCID ProfileMyriam Fornage, Barry I. Freedman, Valentin Fuster, Ma. Eugenia Garay-Sevilla, Humberto García-Ortiz, Soren Germer, Richard A. Gibbs, Christian Gieger, Benjamin Glaser, Clicerio Gonzalez, Maria Elena Gonzalez-Villalpando, Mariaelisa Graff, Sarah E Graham, Niels Grarup, Leif C. Groop, Xiuqing Guo, Namrata Gupta, Sohee Han, Craig L. Hanis, Torben Hansen, Jiang He, Nancy L. Heard-Costa, Yi-Jen Hung, Mi Yeong Hwang, Marguerite R. Irvin, Sergio Islas-Andrade, Gail P. Jarvik, View ORCID ProfileHyun Min Kang, Sharon L.R. Kardia, Tanika Kelly, Eimear E. Kenny, Alyna T. Khan, Bong-Jo Kim, Ryan W. Kim, Young Jin Kim, Heikki A. Koistinen, Charles Kooperberg, Johanna Kuusisto, Soo Heon Kwak, Markku Laakso, Leslie A. Lange, Jiwon Lee, Juyoung Lee, Seonwook Lee, Donna M. Lehman, Rozenn N. Lemaitre, Allan Linneberg, Jianjun Liu, Ruth J.F. Loos, View ORCID ProfileSteven A. Lubitz, Valeriya Lyssenko, Ronald C.W. Ma, Lisa Warsinger Martin, Angélica Martínez-Hernández, Rasika A. Mathias, Stephen T. McGarvey, Ruth McPherson, James B. Meigs, View ORCID ProfileThomas Meitinger, Olle Melander, Elvia Mendoza-Caamal, Ginger A. Metcalf, Xuenan Mi, Karen L. Mohlke, May E. Montasser, Jee-Young Moon, Hortensia Moreno-Macías, Alanna C. Morrison, Donna M. Muzny, Sarah C. Nelson, Peter M. Nilsson, Jeffrey R. O’Connell, Marju Orho-Melander, Lorena Orozco, Colin N.A. Palmer, Nicholette D. Palmer, Cheol Joo Park, Kyong Soo Park, Oluf Pedersen, Juan M. Peralta, Patricia A. Peyser, Wendy S. Post, Michael Preuss, Bruce M. Psaty, Qibin Qi, DC Rao, Susan Redline, Alexander P. Reiner, Cristina Revilla-Monsalve, Stephen S. Rich, Nilesh Samani, Heribert Schunkert, Claudia Schurmann, Daekwan Seo, Jeong-Sun Seo, Xueling Sim, Rob Sladek, Kerrin S. Small, Wing Yee So, Adrienne M. Stilp, S. Margaret Sunitha, E Shyong Tai, Claudia H.T. Tam, Kent D. Taylor, Yik Ying Teo, Farook Thameem, Brian Tomlinson, Michael Y. Tsai, Tiinamaija Tuomi, Jaakko Tuomilehto, Teresa Tusié-Luna, Rob M. van Dam, Ramachandran S. Vasan, Karine A. Viaud Martinez, Fei Fei Wang, Xuzhi Wang, Hugh Watkins, Daniel E. Weeks, James G. Wilson, Daniel R. Witte, Tien-Yin Wong, Lisa R. Yanek, AMP-T2D-GENES, Myocardial Infarction Genetics Consortium, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, NHLBI TOPMed Lipids Working Group, Sekar Kathiresan, Jerome I. Rotter, Michael Boehnke, Mark I. McCarthy, View ORCID ProfileCristen J. Willer, View ORCID ProfilePradeep Natarajan, Jason A. Flannick, Amit V. Khera, Gina M. Peloso
doi: https://doi.org/10.1101/2020.12.22.423783
George Hindy
1Department of Population Medicine, Qatar University College of Medicine, QU Health, Doha, Qatar
2Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA, 02142
3Department of Clinical Sciences, Lund University, Malmö, Sweden
Peter Dornbos
4Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
5Department of Pediatrics, Harvard Medical School, Boston, MA, USA, 02115
6Division of Genetics and Genomics, Boston Children’s Hospital, Boston, MA, USA, 02115
Mark D. Chaffin
2Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA, 02142
7Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA, 02114
8Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA, 02114
Dajiang J. Liu
9Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, 17033
Minxian Wang
2Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA, 02142
7Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA, 02114
10Cardiovascular Disease Initaitive, Broad Institute of Harvard and MIT, Cambridge, MA, USA, 02142
Carlos A. Aguilar-Salinas
11Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico
Lucinda Antonacci-Fulton
12Department of Genetics, Washington University in St. Louis, St. Louis, MO, 63110, USA
13The McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, 63108, USA
Diego Ardissino
14ASTC: Associazione per lo Studio Della Trombosi in Cardiologia, Pavia, Italy
15Azienda Ospedaliero-Universitaria di Parma, ÊParma, Italy
16Universit^ degli Studi di Parma, Parma, Italy
Donna K. Arnett
17Dean’s Office, College of Public Health, University of Kentucky
Stella Aslibekyan
18Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA
Gil Atzmon
19Departments of Medicine and Genetics, Albert Einstein College of Medicine, New York, USA
20University of Haifa, Faculty of natural science, Haifa, Isarel
Christie M. Ballantyne
21Houston Methodist Debakey Heart and Vascular Center, Houston, TX, USA, 77030
22Section of Cardiovascular Research, Baylor College of Medicine, Houston, TX, USA, 77030
Francisco Barajas-Olmos
23Instituto Nacional de Medicina Genómica, Mexico City, Mexico
Nir Barzilai
19Departments of Medicine and Genetics, Albert Einstein College of Medicine, New York, USA
Lewis C. Becker
24Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA 21287
Lawrence F. Bielak
25Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA 49109
Joshua C. Bis
26Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA, 98101
John Blangero
27Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX 78520, USA
Eric Boerwinkle
28Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA, 77030
29Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, 77030, USA
Lori L. Bonnycastle
30Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
Erwin Bottinger
31Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
32Digital Health Center, Hasso Plattner Institute, University of Potsdam, Potsdam, Germany
Donald W. Bowden
33Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA, 27157
Matthew J. Bown
34Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
35NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester UK
Jennifer A. Brody
26Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA, 98101
Jai G. Broome
36Department of Biostatistics, University of Washington, Seattle, WA, USA, 98195
Noël P. Burtt
4Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
Brian E. Cade
37Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115
38Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115
Federico Centeno-Cruz
23Instituto Nacional de Medicina Genómica, Mexico City, Mexico
Edmund Chan
39Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore
Yi-Cheng Chang
40Institute of Biomedical Sciences, Academia Sinica, Taiwan
Yii-Der I. Chen
41The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502
Ching-Yu Cheng
42Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore
43Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore
44Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
Won Jung Choi
45Psomagen. Inc. (formerly Macrogen USA), 1330 Piccard Drive Ste 103, Rockville, MD 20850
Rajiv Chowdhury
46MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
47Centre for Non-Communicable disease Research (CNCR), Bangladesh
Cecilia Contreras-Cubas
23Instituto Nacional de Medicina Genómica, Mexico City, Mexico
Emilio J. Córdova
23Instituto Nacional de Medicina Genómica, Mexico City, Mexico
Adolfo Correa
48Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA, 39216
L Adrienne Cupples
49Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA
50NHLBI Framingham Heart Study, Framingham, Massachusetts, USA
Joanne E. Curran
27Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX 78520, USA
John Danesh
46MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
51The National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics at the University of Cambridge, Cambridge, UK
Paul S. de Vries
28Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA, 77030
Ralph A. DeFronzo
52Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
Harsha Doddapaneni
29Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, 77030, USA
Ravindranath Duggirala
27Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX 78520, USA
Susan K. Dutcher
12Department of Genetics, Washington University in St. Louis, St. Louis, MO, 63110, USA
13The McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, 63108, USA
Patrick T. Ellinor
8Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA, 02114
10Cardiovascular Disease Initaitive, Broad Institute of Harvard and MIT, Cambridge, MA, USA, 02142
Leslie S. Emery
36Department of Biostatistics, University of Washington, Seattle, WA, USA, 98195
Jose C. Florez
2Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA, 02142
7Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA, 02114
53Diabetes Research Center (Diabetes Unit), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
54Department of Medicine, Harvard Medical School, Boston, MA, USA, 02115
Myriam Fornage
55Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 770030
Barry I. Freedman
56Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA 27157
Valentin Fuster
57Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029
58Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain
Ma. Eugenia Garay-Sevilla
59Department of Medical Science, Division of Health Science, University of Guanajuato
Humberto García-Ortiz
23Instituto Nacional de Medicina Genómica, Mexico City, Mexico
Soren Germer
60New York Genome Center, New York, NY, 10013, USA
Richard A. Gibbs
29Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, 77030, USA
61Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA
Christian Gieger
62Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
63Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
64German Center for Diabetes Research (DZD), Neuherberg, Germany
Benjamin Glaser
65Endocrinology and Metabolism Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
Clicerio Gonzalez
66Unidad de Diabetes y Riesgo Cardiovascular, Instituto Nacional de Salud Pœblica, Cuernavaca, Morelos, Mexico
Maria Elena Gonzalez-Villalpando
67Centro de Estudios en Diabetes, Mexico City, Mexico
Mariaelisa Graff
68Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA
Sarah E Graham
69Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109
Niels Grarup
70Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Leif C. Groop
71Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden
72Finnish Institute for Molecular Genetics, University of Helsinki, Helsinki, Finland
Xiuqing Guo
41The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502
Namrata Gupta
2Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA, 02142
Sohee Han
73Division of Genome Science, Department of Precision Medicine, Chungcheongbuk-do, Republic of Korea
Craig L. Hanis
74Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA
Torben Hansen
70Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
75Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark
Jiang He
76Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112
77Tulane University Translational Science Institute, New Orleans, LA 70112
Nancy L. Heard-Costa
50NHLBI Framingham Heart Study, Framingham, Massachusetts, USA
78Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
Yi-Jen Hung
79Division of Endocrine and Metabolism, Tri-Service General Hospital Songshan branch, Taipei, Taiwan
Mi Yeong Hwang
73Division of Genome Science, Department of Precision Medicine, Chungcheongbuk-do, Republic of Korea
Marguerite R. Irvin
80Department of Epidemiology, School of Public Health, UAB, Birmingham AL 35294
Sergio Islas-Andrade
81Dirección de Investigación, Hospital General de México “Dr. Eduardo Liceaga”, Secretaría de Salud, Mexico City, Mexico
Gail P. Jarvik
82Departments of Medicine (Medical Genetics) and Genome Sciences, University of Washington Medical Center, Seattle, WA 98195
Hyun Min Kang
83Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, 48109
Sharon L.R. Kardia
25Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA 49109
Tanika Kelly
76Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112
Eimear E. Kenny
57Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029
84Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029
85Institute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029
Alyna T. Khan
36Department of Biostatistics, University of Washington, Seattle, WA, USA, 98195
Bong-Jo Kim
73Division of Genome Science, Department of Precision Medicine, Chungcheongbuk-do, Republic of Korea
Ryan W. Kim
45Psomagen. Inc. (formerly Macrogen USA), 1330 Piccard Drive Ste 103, Rockville, MD 20850
Young Jin Kim
73Division of Genome Science, Department of Precision Medicine, Chungcheongbuk-do, Republic of Korea
Heikki A. Koistinen
86Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland
87Minerva Foundation Institute for Medical Research, Helsinki, Finland
88University of Helsinki and Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
Charles Kooperberg
89Division of Public Health Sciences, Fred Huchinson Cancer Research Center, Seattle WA USA, 98103
Johanna Kuusisto
90Institute of Clinical Medicine, University of Eastern Finland, and Kuopio University Hospital, Kuopio, Finland
Soo Heon Kwak
91Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea
Markku Laakso
90Institute of Clinical Medicine, University of Eastern Finland, and Kuopio University Hospital, Kuopio, Finland
Leslie A. Lange
92Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA 80045
Jiwon Lee
37Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115
Juyoung Lee
73Division of Genome Science, Department of Precision Medicine, Chungcheongbuk-do, Republic of Korea
Seonwook Lee
45Psomagen. Inc. (formerly Macrogen USA), 1330 Piccard Drive Ste 103, Rockville, MD 20850
Donna M. Lehman
52Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
Rozenn N. Lemaitre
26Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA, 98101
Allan Linneberg
93Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark
94Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Jianjun Liu
39Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore
95Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore
Ruth J.F. Loos
96Charles R. Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA
97The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029
Steven A. Lubitz
8Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA, 02114
10Cardiovascular Disease Initaitive, Broad Institute of Harvard and MIT, Cambridge, MA, USA, 02142
Valeriya Lyssenko
71Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden
98University of Bergen, Norway
Ronald C.W. Ma
99Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
100Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China
101Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
Lisa Warsinger Martin
102Division of Cardiology, Department of Medicine, George Washington University, Washington, D.C. USA 20037
Angélica Martínez-Hernández
23Instituto Nacional de Medicina Genómica, Mexico City, Mexico
Rasika A. Mathias
24Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA 21287
Stephen T. McGarvey
103Department of Epidemiology and International Health Institute, Brown University School of Public Health, Providence, RI 02912
Ruth McPherson
104Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Canada
James B. Meigs
54Department of Medicine, Harvard Medical School, Boston, MA, USA, 02115
105General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, USA
106Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
Thomas Meitinger
107Deutsches Forschungszentrum fŸr Herz-Kreislauferkrankungen (DZHK), Partner Site Munich Heart Alliance, Munich, Germany
108Institute of Human Genetics, Technische Universität München, Munich, Germany
Olle Melander
71Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden
109Department of Emergency and Internal Medicine, SkŒne University Hospital, Malmö, Sweden
Elvia Mendoza-Caamal
23Instituto Nacional de Medicina Genómica, Mexico City, Mexico
Ginger A. Metcalf
29Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, 77030, USA
Xuenan Mi
76Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112
Karen L. Mohlke
110Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA
May E. Montasser
111University of Maryland School of Medicine, Division of Endocrinology, Diabetes and Nutrition and Program for Personalized and Genomic Medicine, Baltimore, MD, USA, 21201
Jee-Young Moon
112Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA 10461
Hortensia Moreno-Macías
113Universidad Autónoma Metropolitana, Mexico City, Mexico
Alanna C. Morrison
28Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA, 77030
Donna M. Muzny
29Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, 77030, USA
Sarah C. Nelson
36Department of Biostatistics, University of Washington, Seattle, WA, USA, 98195
Peter M. Nilsson
3Department of Clinical Sciences, Lund University, Malmö, Sweden
Jeffrey R. O’Connell
111University of Maryland School of Medicine, Division of Endocrinology, Diabetes and Nutrition and Program for Personalized and Genomic Medicine, Baltimore, MD, USA, 21201
Marju Orho-Melander
3Department of Clinical Sciences, Lund University, Malmö, Sweden
Lorena Orozco
23Instituto Nacional de Medicina Genómica, Mexico City, Mexico
Colin N.A. Palmer
114Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Division of Population Health and Genomics, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
Nicholette D. Palmer
33Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA, 27157
Cheol Joo Park
45Psomagen. Inc. (formerly Macrogen USA), 1330 Piccard Drive Ste 103, Rockville, MD 20850
Kyong Soo Park
91Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea
115Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
116Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea
Oluf Pedersen
70Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Juan M. Peralta
27Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX 78520, USA
Patricia A. Peyser
25Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA 49109
Wendy S. Post
117Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
Michael Preuss
96Charles R. Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Bruce M. Psaty
26Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA, 98101
118Department of Epidemiology, University of Washington, Seattle, WA, USA 98101
119Department of Health Services, University of Washington, Seattle, WA, USA 98101
Qibin Qi
112Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA 10461
DC Rao
120Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA
Susan Redline
37Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115
38Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115
Alexander P. Reiner
121University of Washington, Seattle, Washington, USA
Cristina Revilla-Monsalve
122Instituto Mexicano del Seguro Social SXXI, Mexico City, Mexico
Stephen S. Rich
123Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA
Nilesh Samani
34Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
35NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester UK
Heribert Schunkert
124Deutsches Herzzentrum MŸnchen, Technische UniversitŠt MŸnchen, Deutsches Zentrum fŸr Herz-Kreislauf-Forschung, MŸnchen, Germany
Claudia Schurmann
31Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
32Digital Health Center, Hasso Plattner Institute, University of Potsdam, Potsdam, Germany
96Charles R. Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Daekwan Seo
45Psomagen. Inc. (formerly Macrogen USA), 1330 Piccard Drive Ste 103, Rockville, MD 20850
Jeong-Sun Seo
45Psomagen. Inc. (formerly Macrogen USA), 1330 Piccard Drive Ste 103, Rockville, MD 20850
Xueling Sim
125Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore
Rob Sladek
126Department of Human Genetics, McGill University, Montreal, Quebec, Canada
127Division of Endocrinology and Metabolism, Department of Medicine, McGill University, Montreal, Quebec, Canada
128McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada
Kerrin S. Small
129Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK
Wing Yee So
99Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
100Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China
101Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
Adrienne M. Stilp
36Department of Biostatistics, University of Washington, Seattle, WA, USA, 98195
S. Margaret Sunitha
2Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA, 02142
7Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA, 02114
E Shyong Tai
39Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore
125Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore
130Duke-NUS Medical School Singapore, Singapore
Claudia H.T. Tam
99Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
100Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China
101Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
Kent D. Taylor
41The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502
Yik Ying Teo
125Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore
131Department of Statistics and Applied Probability, National University of Singapore, Singapore
132Life Sciences Institute, National University of Singapore, Singapore
Farook Thameem
133Department of Biochemistry, Faculty of Medicine, Health Science Center, Kuwait University, Safat, Kuwait
Brian Tomlinson
134Faculty of Medicine, Macau University of Science & Technology, Macau, China
Michael Y. Tsai
135Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA
Tiinamaija Tuomi
136Department of Endocrinology, Abdominal Centre, Helsinki University Hospital, Helsinki, Finland
137Folkhälsan Research Centre, Helsinki, Finland
138Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland
Jaakko Tuomilehto
139Public Health Promition Unit, Finnish Institute for Health and Welfare, Helsinki, Finland
140Department of Public Health, University of Helsinki, Helsinki, Finland
141Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia
Teresa Tusié-Luna
11Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico
142Departamento de Medicina Genómica y Toxicología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México/ Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Rob M. van Dam
125Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore
143Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
Ramachandran S. Vasan
50NHLBI Framingham Heart Study, Framingham, Massachusetts, USA
144Departments of Medicine & Epidemiology, Boston University Schools of Medicine & Public Health, Boston, MA
Karine A. Viaud Martinez
145Illumina Laboratory Services, Illumina inc., San Diego, CA, 92122, USA
Fei Fei Wang
36Department of Biostatistics, University of Washington, Seattle, WA, USA, 98195
Xuzhi Wang
49Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA
Hugh Watkins
146Cardiovascular Medicine, Radcliffe Department of Medicine and the Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Daniel E. Weeks
147Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261
148Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261
James G. Wilson
149Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215
Daniel R. Witte
150Department of Public Health, Aarhus University, Aarhus, Denmark
151Steno Diabetes Center Aarhus, Aarhus, Denmark
Tien-Yin Wong
42Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore
43Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore
44Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
Lisa R. Yanek
24Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA 21287
Sekar Kathiresan
2Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA, 02142
7Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA, 02114
54Department of Medicine, Harvard Medical School, Boston, MA, USA, 02115
152Verve Therapeutics, Cambridge, MA, USA 02139
Jerome I. Rotter
41The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502
Michael Boehnke
83Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, 48109
Mark I. McCarthy
153Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK
154Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK
Cristen J. Willer
69Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109
155Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109
156Department of Human Genetics, University of Michigan, Ann Arbor, MI, 48109
Pradeep Natarajan
2Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA, 02142
8Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA, 02114
10Cardiovascular Disease Initaitive, Broad Institute of Harvard and MIT, Cambridge, MA, USA, 02142
54Department of Medicine, Harvard Medical School, Boston, MA, USA, 02115
Jason A. Flannick
4Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
5Department of Pediatrics, Harvard Medical School, Boston, MA, USA, 02115
6Division of Genetics and Genomics, Boston Children’s Hospital, Boston, MA, USA, 02115
Amit V. Khera
2Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA, 02142
7Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA, 02114
8Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA, 02114
Gina M. Peloso
49Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA
Article usage
Posted December 23, 2020.
Rare coding variants in 35 genes associate with circulating lipid levels – a multi-ancestry analysis of 170,000 exomes
George Hindy, Peter Dornbos, Mark D. Chaffin, Dajiang J. Liu, Minxian Wang, Carlos A. Aguilar-Salinas, Lucinda Antonacci-Fulton, Diego Ardissino, Donna K. Arnett, Stella Aslibekyan, Gil Atzmon, Christie M. Ballantyne, Francisco Barajas-Olmos, Nir Barzilai, Lewis C. Becker, Lawrence F. Bielak, Joshua C. Bis, John Blangero, Eric Boerwinkle, Lori L. Bonnycastle, Erwin Bottinger, Donald W. Bowden, Matthew J. Bown, Jennifer A. Brody, Jai G. Broome, Noël P. Burtt, Brian E. Cade, Federico Centeno-Cruz, Edmund Chan, Yi-Cheng Chang, Yii-Der I. Chen, Ching-Yu Cheng, Won Jung Choi, Rajiv Chowdhury, Cecilia Contreras-Cubas, Emilio J. Córdova, Adolfo Correa, L Adrienne Cupples, Joanne E. Curran, John Danesh, Paul S. de Vries, Ralph A. DeFronzo, Harsha Doddapaneni, Ravindranath Duggirala, Susan K. Dutcher, Patrick T. Ellinor, Leslie S. Emery, Jose C. Florez, Myriam Fornage, Barry I. Freedman, Valentin Fuster, Ma. Eugenia Garay-Sevilla, Humberto García-Ortiz, Soren Germer, Richard A. Gibbs, Christian Gieger, Benjamin Glaser, Clicerio Gonzalez, Maria Elena Gonzalez-Villalpando, Mariaelisa Graff, Sarah E Graham, Niels Grarup, Leif C. Groop, Xiuqing Guo, Namrata Gupta, Sohee Han, Craig L. Hanis, Torben Hansen, Jiang He, Nancy L. Heard-Costa, Yi-Jen Hung, Mi Yeong Hwang, Marguerite R. Irvin, Sergio Islas-Andrade, Gail P. Jarvik, Hyun Min Kang, Sharon L.R. Kardia, Tanika Kelly, Eimear E. Kenny, Alyna T. Khan, Bong-Jo Kim, Ryan W. Kim, Young Jin Kim, Heikki A. Koistinen, Charles Kooperberg, Johanna Kuusisto, Soo Heon Kwak, Markku Laakso, Leslie A. Lange, Jiwon Lee, Juyoung Lee, Seonwook Lee, Donna M. Lehman, Rozenn N. Lemaitre, Allan Linneberg, Jianjun Liu, Ruth J.F. Loos, Steven A. Lubitz, Valeriya Lyssenko, Ronald C.W. Ma, Lisa Warsinger Martin, Angélica Martínez-Hernández, Rasika A. Mathias, Stephen T. McGarvey, Ruth McPherson, James B. Meigs, Thomas Meitinger, Olle Melander, Elvia Mendoza-Caamal, Ginger A. Metcalf, Xuenan Mi, Karen L. Mohlke, May E. Montasser, Jee-Young Moon, Hortensia Moreno-Macías, Alanna C. Morrison, Donna M. Muzny, Sarah C. Nelson, Peter M. Nilsson, Jeffrey R. O’Connell, Marju Orho-Melander, Lorena Orozco, Colin N.A. Palmer, Nicholette D. Palmer, Cheol Joo Park, Kyong Soo Park, Oluf Pedersen, Juan M. Peralta, Patricia A. Peyser, Wendy S. Post, Michael Preuss, Bruce M. Psaty, Qibin Qi, DC Rao, Susan Redline, Alexander P. Reiner, Cristina Revilla-Monsalve, Stephen S. Rich, Nilesh Samani, Heribert Schunkert, Claudia Schurmann, Daekwan Seo, Jeong-Sun Seo, Xueling Sim, Rob Sladek, Kerrin S. Small, Wing Yee So, Adrienne M. Stilp, S. Margaret Sunitha, E Shyong Tai, Claudia H.T. Tam, Kent D. Taylor, Yik Ying Teo, Farook Thameem, Brian Tomlinson, Michael Y. Tsai, Tiinamaija Tuomi, Jaakko Tuomilehto, Teresa Tusié-Luna, Rob M. van Dam, Ramachandran S. Vasan, Karine A. Viaud Martinez, Fei Fei Wang, Xuzhi Wang, Hugh Watkins, Daniel E. Weeks, James G. Wilson, Daniel R. Witte, Tien-Yin Wong, Lisa R. Yanek, AMP-T2D-GENES, Myocardial Infarction Genetics Consortium, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, NHLBI TOPMed Lipids Working Group, Sekar Kathiresan, Jerome I. Rotter, Michael Boehnke, Mark I. McCarthy, Cristen J. Willer, Pradeep Natarajan, Jason A. Flannick, Amit V. Khera, Gina M. Peloso
bioRxiv 2020.12.22.423783; doi: https://doi.org/10.1101/2020.12.22.423783
Rare coding variants in 35 genes associate with circulating lipid levels – a multi-ancestry analysis of 170,000 exomes
George Hindy, Peter Dornbos, Mark D. Chaffin, Dajiang J. Liu, Minxian Wang, Carlos A. Aguilar-Salinas, Lucinda Antonacci-Fulton, Diego Ardissino, Donna K. Arnett, Stella Aslibekyan, Gil Atzmon, Christie M. Ballantyne, Francisco Barajas-Olmos, Nir Barzilai, Lewis C. Becker, Lawrence F. Bielak, Joshua C. Bis, John Blangero, Eric Boerwinkle, Lori L. Bonnycastle, Erwin Bottinger, Donald W. Bowden, Matthew J. Bown, Jennifer A. Brody, Jai G. Broome, Noël P. Burtt, Brian E. Cade, Federico Centeno-Cruz, Edmund Chan, Yi-Cheng Chang, Yii-Der I. Chen, Ching-Yu Cheng, Won Jung Choi, Rajiv Chowdhury, Cecilia Contreras-Cubas, Emilio J. Córdova, Adolfo Correa, L Adrienne Cupples, Joanne E. Curran, John Danesh, Paul S. de Vries, Ralph A. DeFronzo, Harsha Doddapaneni, Ravindranath Duggirala, Susan K. Dutcher, Patrick T. Ellinor, Leslie S. Emery, Jose C. Florez, Myriam Fornage, Barry I. Freedman, Valentin Fuster, Ma. Eugenia Garay-Sevilla, Humberto García-Ortiz, Soren Germer, Richard A. Gibbs, Christian Gieger, Benjamin Glaser, Clicerio Gonzalez, Maria Elena Gonzalez-Villalpando, Mariaelisa Graff, Sarah E Graham, Niels Grarup, Leif C. Groop, Xiuqing Guo, Namrata Gupta, Sohee Han, Craig L. Hanis, Torben Hansen, Jiang He, Nancy L. Heard-Costa, Yi-Jen Hung, Mi Yeong Hwang, Marguerite R. Irvin, Sergio Islas-Andrade, Gail P. Jarvik, Hyun Min Kang, Sharon L.R. Kardia, Tanika Kelly, Eimear E. Kenny, Alyna T. Khan, Bong-Jo Kim, Ryan W. Kim, Young Jin Kim, Heikki A. Koistinen, Charles Kooperberg, Johanna Kuusisto, Soo Heon Kwak, Markku Laakso, Leslie A. Lange, Jiwon Lee, Juyoung Lee, Seonwook Lee, Donna M. Lehman, Rozenn N. Lemaitre, Allan Linneberg, Jianjun Liu, Ruth J.F. Loos, Steven A. Lubitz, Valeriya Lyssenko, Ronald C.W. Ma, Lisa Warsinger Martin, Angélica Martínez-Hernández, Rasika A. Mathias, Stephen T. McGarvey, Ruth McPherson, James B. Meigs, Thomas Meitinger, Olle Melander, Elvia Mendoza-Caamal, Ginger A. Metcalf, Xuenan Mi, Karen L. Mohlke, May E. Montasser, Jee-Young Moon, Hortensia Moreno-Macías, Alanna C. Morrison, Donna M. Muzny, Sarah C. Nelson, Peter M. Nilsson, Jeffrey R. O’Connell, Marju Orho-Melander, Lorena Orozco, Colin N.A. Palmer, Nicholette D. Palmer, Cheol Joo Park, Kyong Soo Park, Oluf Pedersen, Juan M. Peralta, Patricia A. Peyser, Wendy S. Post, Michael Preuss, Bruce M. Psaty, Qibin Qi, DC Rao, Susan Redline, Alexander P. Reiner, Cristina Revilla-Monsalve, Stephen S. Rich, Nilesh Samani, Heribert Schunkert, Claudia Schurmann, Daekwan Seo, Jeong-Sun Seo, Xueling Sim, Rob Sladek, Kerrin S. Small, Wing Yee So, Adrienne M. Stilp, S. Margaret Sunitha, E Shyong Tai, Claudia H.T. Tam, Kent D. Taylor, Yik Ying Teo, Farook Thameem, Brian Tomlinson, Michael Y. Tsai, Tiinamaija Tuomi, Jaakko Tuomilehto, Teresa Tusié-Luna, Rob M. van Dam, Ramachandran S. Vasan, Karine A. Viaud Martinez, Fei Fei Wang, Xuzhi Wang, Hugh Watkins, Daniel E. Weeks, James G. Wilson, Daniel R. Witte, Tien-Yin Wong, Lisa R. Yanek, AMP-T2D-GENES, Myocardial Infarction Genetics Consortium, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, NHLBI TOPMed Lipids Working Group, Sekar Kathiresan, Jerome I. Rotter, Michael Boehnke, Mark I. McCarthy, Cristen J. Willer, Pradeep Natarajan, Jason A. Flannick, Amit V. Khera, Gina M. Peloso
bioRxiv 2020.12.22.423783; doi: https://doi.org/10.1101/2020.12.22.423783
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