Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Heterogeneity of Neuronal Populations Within Columns of Primate V1 Revealed by High-Density Recordings

View ORCID ProfileShude Zhu, View ORCID ProfileRuobing Xia, View ORCID ProfileXiaomo Chen, View ORCID ProfileTirin Moore
doi: https://doi.org/10.1101/2020.12.22.424048
Shude Zhu
Department of Neurobiology and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Shude Zhu
Ruobing Xia
Department of Neurobiology and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Ruobing Xia
Xiaomo Chen
Department of Neurobiology and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Xiaomo Chen
Tirin Moore
Department of Neurobiology and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Tirin Moore
  • For correspondence: tirin@stanford.edu
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Primary visual cortex (V1) has been the focus of extensive neurophysiological investigation, and its laminar organization provides a key exemplar of the functional logic of neocortical microcircuits. Using newly developed high-density, linear array probes, we measured visual responses from large populations of simultaneously recorded neurons distributed across layers of macaque V1. In single recordings, myriad differences in the functional properties of neuronal subpopulations could be observed. In particular, we found that although standard measurements of orientation selectivity yielded only minor differences between laminar compartments, decoding of stimulus orientation from layer 4C responses was superior to that of both superficial and deep layers within the same cortical column. The superior orientation discrimination within layer 4C was associated with greater response reliability of individual neurons rather than lower correlated activity with neuronal populations. The results demonstrate the utility of high-density electrophysiology in revealing the functional organization and network properties of neocortical microcircuits in single experiments.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted December 22, 2020.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Heterogeneity of Neuronal Populations Within Columns of Primate V1 Revealed by High-Density Recordings
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Heterogeneity of Neuronal Populations Within Columns of Primate V1 Revealed by High-Density Recordings
Shude Zhu, Ruobing Xia, Xiaomo Chen, Tirin Moore
bioRxiv 2020.12.22.424048; doi: https://doi.org/10.1101/2020.12.22.424048
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Heterogeneity of Neuronal Populations Within Columns of Primate V1 Revealed by High-Density Recordings
Shude Zhu, Ruobing Xia, Xiaomo Chen, Tirin Moore
bioRxiv 2020.12.22.424048; doi: https://doi.org/10.1101/2020.12.22.424048

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (4850)
  • Biochemistry (10791)
  • Bioengineering (8040)
  • Bioinformatics (27281)
  • Biophysics (13971)
  • Cancer Biology (11119)
  • Cell Biology (16048)
  • Clinical Trials (138)
  • Developmental Biology (8777)
  • Ecology (13276)
  • Epidemiology (2067)
  • Evolutionary Biology (17353)
  • Genetics (11687)
  • Genomics (15915)
  • Immunology (11027)
  • Microbiology (26069)
  • Molecular Biology (10637)
  • Neuroscience (56525)
  • Paleontology (417)
  • Pathology (1732)
  • Pharmacology and Toxicology (3003)
  • Physiology (4543)
  • Plant Biology (9627)
  • Scientific Communication and Education (1614)
  • Synthetic Biology (2685)
  • Systems Biology (6975)
  • Zoology (1508)