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SARS-CoV-2 mutations among minks show reduced lethality and infectivity to humans

View ORCID ProfileTomokazu Konishi
doi: https://doi.org/10.1101/2020.12.23.424267
Tomokazu Konishi
Graduate School of Bioresource Sciences, Akita Prefectural University
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  • For correspondence: konishi@akita-pu.ac.jp
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Abstract

SARS-CoV-2 infection in minks has become a serious problem, as the virus may mutate and reinfect humans; some countries have decided to cull minks. Here, the virus sequencing data in minks were analysed and compared to those of human-virus. Although the mink-virus maintained the characteristics of human-virus, some variants rapidly mutated, adapting to minks. Some mink-derived variants infected humans, which accounted for 40% of the total SARS-CoV-2 cases in the Netherlands. These variants appear to be less lethal and infective compared to those in humans. Variants that have mutated further among minks were not found in humans. Such mink-virus might be suitable for vaccination for humans, such as in the case of the smallpox virus, which is less infective and toxic to humans.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • https://doi.org/10.6084/m9.figshare.13385192.v1

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted December 27, 2020.
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SARS-CoV-2 mutations among minks show reduced lethality and infectivity to humans
Tomokazu Konishi
bioRxiv 2020.12.23.424267; doi: https://doi.org/10.1101/2020.12.23.424267
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SARS-CoV-2 mutations among minks show reduced lethality and infectivity to humans
Tomokazu Konishi
bioRxiv 2020.12.23.424267; doi: https://doi.org/10.1101/2020.12.23.424267

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