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Mechanical frustration of phase separation in the cell nucleus by chromatin

View ORCID ProfileYaojun Zhang, View ORCID ProfileDaniel S.W. Lee, Yigal Meir, Clifford P. Brangwynne, View ORCID ProfileNed S. Wingreen
doi: https://doi.org/10.1101/2020.12.24.424222
Yaojun Zhang
1Department of Physics, Princeton University, Princeton, NJ 08544, USA
2Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
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  • ORCID record for Yaojun Zhang
Daniel S.W. Lee
2Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
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Yigal Meir
1Department of Physics, Princeton University, Princeton, NJ 08544, USA
3Department of Physics, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
4Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
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Clifford P. Brangwynne
5Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA
6Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA
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Ned S. Wingreen
2Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
4Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
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  • For correspondence: wingreen@princeton.edu
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Article Information

doi 
https://doi.org/10.1101/2020.12.24.424222
History 
  • December 24, 2020.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Yaojun Zhang1,2,*,
  2. Daniel S.W. Lee2,*,
  3. Yigal Meir1,3,4,
  4. Clifford P. Brangwynne5,6 and
  5. Ned S. Wingreen2,4,†
  1. 1Department of Physics, Princeton University, Princeton, NJ 08544, USA
  2. 2Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
  3. 3Department of Physics, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
  4. 4Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
  5. 5Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA
  6. 6Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA
  1. ↵†Author to whom correspondence should be addressed. Email: wingreen{at}princeton.edu.
  1. ↵* These two authors contributed equally.

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Posted December 24, 2020.
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Mechanical frustration of phase separation in the cell nucleus by chromatin
Yaojun Zhang, Daniel S.W. Lee, Yigal Meir, Clifford P. Brangwynne, Ned S. Wingreen
bioRxiv 2020.12.24.424222; doi: https://doi.org/10.1101/2020.12.24.424222
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Mechanical frustration of phase separation in the cell nucleus by chromatin
Yaojun Zhang, Daniel S.W. Lee, Yigal Meir, Clifford P. Brangwynne, Ned S. Wingreen
bioRxiv 2020.12.24.424222; doi: https://doi.org/10.1101/2020.12.24.424222

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