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Genetic epidemiology of variants associated with immune escape from global SARS-CoV-2 genomes
View ORCID ProfileBani Jolly, View ORCID ProfileMercy Rophina, Afra Shamnath, Mohammed Imran, View ORCID ProfileRahul C. Bhoyar, View ORCID ProfileMohit Kumar Divakar, Pallavali Roja Rani, View ORCID ProfileGyan Ranjan, View ORCID ProfileParas Sehgal, Pulala Chandrasekhar, S. Afsar, J. Vijaya Lakshmi, A. Surekha, View ORCID ProfileSridhar Sivasubbu, View ORCID ProfileVinod Scaria
doi: https://doi.org/10.1101/2020.12.24.424332
Bani Jolly
1CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), New Delhi, India
2Academy of Scientific and Innovative Research (AcSIR), CSIR-HRDC Ghaziabad, Uttar Pradesh, India Ranjan, P. Sehgal, S. Sivasubbu, V. Scaria)
Mercy Rophina
1CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), New Delhi, India
2Academy of Scientific and Innovative Research (AcSIR), CSIR-HRDC Ghaziabad, Uttar Pradesh, India Ranjan, P. Sehgal, S. Sivasubbu, V. Scaria)
Afra Shamnath
1CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), New Delhi, India
Mohammed Imran
1CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), New Delhi, India
2Academy of Scientific and Innovative Research (AcSIR), CSIR-HRDC Ghaziabad, Uttar Pradesh, India Ranjan, P. Sehgal, S. Sivasubbu, V. Scaria)
Rahul C. Bhoyar
1CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), New Delhi, India
Mohit Kumar Divakar
1CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), New Delhi, India
2Academy of Scientific and Innovative Research (AcSIR), CSIR-HRDC Ghaziabad, Uttar Pradesh, India Ranjan, P. Sehgal, S. Sivasubbu, V. Scaria)
Pallavali Roja Rani
3Kurnool Medical College, Kurnool, Andhra Pradesh, India
Gyan Ranjan
1CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), New Delhi, India
2Academy of Scientific and Innovative Research (AcSIR), CSIR-HRDC Ghaziabad, Uttar Pradesh, India Ranjan, P. Sehgal, S. Sivasubbu, V. Scaria)
Paras Sehgal
1CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), New Delhi, India
2Academy of Scientific and Innovative Research (AcSIR), CSIR-HRDC Ghaziabad, Uttar Pradesh, India Ranjan, P. Sehgal, S. Sivasubbu, V. Scaria)
Pulala Chandrasekhar
3Kurnool Medical College, Kurnool, Andhra Pradesh, India
S. Afsar
3Kurnool Medical College, Kurnool, Andhra Pradesh, India
J. Vijaya Lakshmi
3Kurnool Medical College, Kurnool, Andhra Pradesh, India
A. Surekha
3Kurnool Medical College, Kurnool, Andhra Pradesh, India
Sridhar Sivasubbu
1CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), New Delhi, India
2Academy of Scientific and Innovative Research (AcSIR), CSIR-HRDC Ghaziabad, Uttar Pradesh, India Ranjan, P. Sehgal, S. Sivasubbu, V. Scaria)
Vinod Scaria
1CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), New Delhi, India
2Academy of Scientific and Innovative Research (AcSIR), CSIR-HRDC Ghaziabad, Uttar Pradesh, India Ranjan, P. Sehgal, S. Sivasubbu, V. Scaria)
Abstract
Many antibody and immune escape variants in SARS-CoV-2 are now documented in literature. The availability of SARS-CoV-2 genome sequences enabled us to investigate the occurrence and genetic epidemiology of the variants globally. Our analysis suggests that a number of genetic variants associated with immune escape have emerged in global populations.
Competing Interest Statement
The authors have declared no competing interest.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Posted December 26, 2020.
Genetic epidemiology of variants associated with immune escape from global SARS-CoV-2 genomes
Bani Jolly, Mercy Rophina, Afra Shamnath, Mohammed Imran, Rahul C. Bhoyar, Mohit Kumar Divakar, Pallavali Roja Rani, Gyan Ranjan, Paras Sehgal, Pulala Chandrasekhar, S. Afsar, J. Vijaya Lakshmi, A. Surekha, Sridhar Sivasubbu, Vinod Scaria
bioRxiv 2020.12.24.424332; doi: https://doi.org/10.1101/2020.12.24.424332
Genetic epidemiology of variants associated with immune escape from global SARS-CoV-2 genomes
Bani Jolly, Mercy Rophina, Afra Shamnath, Mohammed Imran, Rahul C. Bhoyar, Mohit Kumar Divakar, Pallavali Roja Rani, Gyan Ranjan, Paras Sehgal, Pulala Chandrasekhar, S. Afsar, J. Vijaya Lakshmi, A. Surekha, Sridhar Sivasubbu, Vinod Scaria
bioRxiv 2020.12.24.424332; doi: https://doi.org/10.1101/2020.12.24.424332
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