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The neutralization effect of Montelukast on SARS-CoV-2 is shown by multiscale in silico simulations and combined in vitro studies

View ORCID ProfileSerdar Durdagi, Timucin Avsar, Muge Didem Orhan, Muge Serhatli, Bertan Koray Balcioglu, Hasan Umit Ozturk, Alisan Kayabolen, Yuksel Cetin, Seyma Aydinlik, Tugba Bagci-Onder, Saban Tekin, Hasan Demirci, Mustafa Guzel, Atilla Akdemir, Seyma Calis, Lalehan Oktay, Ilayda Tolu, Yasar Enes Butun, Ece Erdemoglu, Alpsu Olkan, Nurettin Tokay, Şeyma Işık, Aysenur Ozcan, Elif Acar, Sehriban Buyukkilic, Yesim Yumak
doi: https://doi.org/10.1101/2020.12.26.424423
Serdar Durdagi
1Computational Biology and Molecular Simulations Laboratory, Department of Biophysics, School of Medicine, Bahçeşehir University, Istanbul, Turkey
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  • ORCID record for Serdar Durdagi
  • For correspondence: serdar.durdagi@med.bau.edu.tr
Timucin Avsar
2Department of Medical Biology, School of Medicine, Bahçeşehir University, Istanbul, Turkey
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Muge Didem Orhan
2Department of Medical Biology, School of Medicine, Bahçeşehir University, Istanbul, Turkey
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Muge Serhatli
3The Scientific and Technological Research Council of Turkey (TÜBITAK) Marmara Research Center (MAM), Genetic Engineering and Biotechnology Institute, 41470 Gebze Kocaeli
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Bertan Koray Balcioglu
3The Scientific and Technological Research Council of Turkey (TÜBITAK) Marmara Research Center (MAM), Genetic Engineering and Biotechnology Institute, 41470 Gebze Kocaeli
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Hasan Umit Ozturk
3The Scientific and Technological Research Council of Turkey (TÜBITAK) Marmara Research Center (MAM), Genetic Engineering and Biotechnology Institute, 41470 Gebze Kocaeli
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Alisan Kayabolen
4Brain Cancer Research and Therapy Laboratory, Koç University School of Medicine, 34450 Istanbul, Turkey
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Yuksel Cetin
3The Scientific and Technological Research Council of Turkey (TÜBITAK) Marmara Research Center (MAM), Genetic Engineering and Biotechnology Institute, 41470 Gebze Kocaeli
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Seyma Aydinlik
3The Scientific and Technological Research Council of Turkey (TÜBITAK) Marmara Research Center (MAM), Genetic Engineering and Biotechnology Institute, 41470 Gebze Kocaeli
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Tugba Bagci-Onder
4Brain Cancer Research and Therapy Laboratory, Koç University School of Medicine, 34450 Istanbul, Turkey
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Saban Tekin
3The Scientific and Technological Research Council of Turkey (TÜBITAK) Marmara Research Center (MAM), Genetic Engineering and Biotechnology Institute, 41470 Gebze Kocaeli
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Hasan Demirci
5Department of Molecular Biology and Genetics, Koç University, 34450, Istanbul, Turkey
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Mustafa Guzel
6Istanbul Medipol University, International School of Medicine, Department of Medical Pharmacology, Istanbul, Turkey
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Atilla Akdemir
7Bezmialem Vakif University, Computer-aided Drug Discovery Laboratory, Department of Pharmacology, Faculty of Pharmacy, Istanbul, Turkey
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Seyma Calis
2Department of Medical Biology, School of Medicine, Bahçeşehir University, Istanbul, Turkey
8Department of Molecular Biology-Genetics and Biotechnology, Istanbul Technical University, 34485, Istanbul, Turkey
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Lalehan Oktay
1Computational Biology and Molecular Simulations Laboratory, Department of Biophysics, School of Medicine, Bahçeşehir University, Istanbul, Turkey
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Ilayda Tolu
1Computational Biology and Molecular Simulations Laboratory, Department of Biophysics, School of Medicine, Bahçeşehir University, Istanbul, Turkey
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Yasar Enes Butun
6Istanbul Medipol University, International School of Medicine, Department of Medical Pharmacology, Istanbul, Turkey
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Ece Erdemoglu
1Computational Biology and Molecular Simulations Laboratory, Department of Biophysics, School of Medicine, Bahçeşehir University, Istanbul, Turkey
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Alpsu Olkan
1Computational Biology and Molecular Simulations Laboratory, Department of Biophysics, School of Medicine, Bahçeşehir University, Istanbul, Turkey
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Nurettin Tokay
3The Scientific and Technological Research Council of Turkey (TÜBITAK) Marmara Research Center (MAM), Genetic Engineering and Biotechnology Institute, 41470 Gebze Kocaeli
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Şeyma Işık
3The Scientific and Technological Research Council of Turkey (TÜBITAK) Marmara Research Center (MAM), Genetic Engineering and Biotechnology Institute, 41470 Gebze Kocaeli
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Aysenur Ozcan
1Computational Biology and Molecular Simulations Laboratory, Department of Biophysics, School of Medicine, Bahçeşehir University, Istanbul, Turkey
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Elif Acar
1Computational Biology and Molecular Simulations Laboratory, Department of Biophysics, School of Medicine, Bahçeşehir University, Istanbul, Turkey
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Sehriban Buyukkilic
1Computational Biology and Molecular Simulations Laboratory, Department of Biophysics, School of Medicine, Bahçeşehir University, Istanbul, Turkey
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Yesim Yumak
1Computational Biology and Molecular Simulations Laboratory, Department of Biophysics, School of Medicine, Bahçeşehir University, Istanbul, Turkey
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Article Information

doi 
https://doi.org/10.1101/2020.12.26.424423
History 
  • December 27, 2020.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.

Author Information

  1. Serdar Durdagi1,*,
  2. Timucin Avsar2,
  3. Muge Didem Orhan2,
  4. Muge Serhatli3,
  5. Bertan Koray Balcioglu3,
  6. Hasan Umit Ozturk3,
  7. Alisan Kayabolen4,
  8. Yuksel Cetin3,
  9. Seyma Aydinlik3,
  10. Tugba Bagci-Onder4,
  11. Saban Tekin3,
  12. Hasan Demirci5,
  13. Mustafa Guzel6,
  14. Atilla Akdemir7,
  15. Seyma Calis2,8,
  16. Lalehan Oktay1,
  17. Ilayda Tolu1,
  18. Yasar Enes Butun6,
  19. Ece Erdemoglu1,
  20. Alpsu Olkan1,
  21. Nurettin Tokay3,
  22. Şeyma Işık3,
  23. Aysenur Ozcan1,
  24. Elif Acar1,
  25. Sehriban Buyukkilic1 and
  26. Yesim Yumak1
  1. 1Computational Biology and Molecular Simulations Laboratory, Department of Biophysics, School of Medicine, Bahçeşehir University, Istanbul, Turkey
  2. 2Department of Medical Biology, School of Medicine, Bahçeşehir University, Istanbul, Turkey
  3. 3The Scientific and Technological Research Council of Turkey (TÜBITAK) Marmara Research Center (MAM), Genetic Engineering and Biotechnology Institute, 41470 Gebze Kocaeli
  4. 4Brain Cancer Research and Therapy Laboratory, Koç University School of Medicine, 34450 Istanbul, Turkey
  5. 5Department of Molecular Biology and Genetics, Koç University, 34450, Istanbul, Turkey
  6. 6Istanbul Medipol University, International School of Medicine, Department of Medical Pharmacology, Istanbul, Turkey
  7. 7Bezmialem Vakif University, Computer-aided Drug Discovery Laboratory, Department of Pharmacology, Faculty of Pharmacy, Istanbul, Turkey
  8. 8Department of Molecular Biology-Genetics and Biotechnology, Istanbul Technical University, 34485, Istanbul, Turkey
  1. ↵*E-mail: serdar.durdagi{at}med.bau.edu.tr; Durdagi Research Group (DRG) durdagilab.com
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Posted December 27, 2020.
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The neutralization effect of Montelukast on SARS-CoV-2 is shown by multiscale in silico simulations and combined in vitro studies
Serdar Durdagi, Timucin Avsar, Muge Didem Orhan, Muge Serhatli, Bertan Koray Balcioglu, Hasan Umit Ozturk, Alisan Kayabolen, Yuksel Cetin, Seyma Aydinlik, Tugba Bagci-Onder, Saban Tekin, Hasan Demirci, Mustafa Guzel, Atilla Akdemir, Seyma Calis, Lalehan Oktay, Ilayda Tolu, Yasar Enes Butun, Ece Erdemoglu, Alpsu Olkan, Nurettin Tokay, Şeyma Işık, Aysenur Ozcan, Elif Acar, Sehriban Buyukkilic, Yesim Yumak
bioRxiv 2020.12.26.424423; doi: https://doi.org/10.1101/2020.12.26.424423
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The neutralization effect of Montelukast on SARS-CoV-2 is shown by multiscale in silico simulations and combined in vitro studies
Serdar Durdagi, Timucin Avsar, Muge Didem Orhan, Muge Serhatli, Bertan Koray Balcioglu, Hasan Umit Ozturk, Alisan Kayabolen, Yuksel Cetin, Seyma Aydinlik, Tugba Bagci-Onder, Saban Tekin, Hasan Demirci, Mustafa Guzel, Atilla Akdemir, Seyma Calis, Lalehan Oktay, Ilayda Tolu, Yasar Enes Butun, Ece Erdemoglu, Alpsu Olkan, Nurettin Tokay, Şeyma Işık, Aysenur Ozcan, Elif Acar, Sehriban Buyukkilic, Yesim Yumak
bioRxiv 2020.12.26.424423; doi: https://doi.org/10.1101/2020.12.26.424423

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