Single-cell Individual Complete mtDNA Sequencing Uncovers Hidden Mitochondrial Heterogeneity in Human and Mouse Oocytes

Chongwei Bi; Lin Wang; Yong Fan; Gerardo Ramos-Mandujano; Baolei Yuan; Xuan Zhou; Jincheng Wang; Yanjiao Shao; Pu-Yao Zhang; Yanyi Huang; Yang Yu; Juan Carlos Izpisua Belmonte; Mo Li

doi:10.1101/2020.12.28.424537

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Single-cell Individual Complete mtDNA Sequencing Uncovers Hidden Mitochondrial Heterogeneity in Human and Mouse Oocytes

Chongwei Bi, Lin Wang, Yong Fan, Gerardo Ramos-Mandujano, Baolei Yuan, Xuan Zhou, Jincheng Wang, Yanjiao Shao, Pu-Yao Zhang, Yanyi Huang, Yang Yu, Juan Carlos Izpisua Belmonte, View ORCID ProfileMo Li

doi: https://doi.org/10.1101/2020.12.28.424537

Chongwei Bi

1Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia

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Lin Wang

1Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia

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Yong Fan

2Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, 510150 Guangzhou, China

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Gerardo Ramos-Mandujano

1Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia

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Baolei Yuan

1Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia

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Xuan Zhou

1Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia

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Jincheng Wang

3Beijing Advanced Innovation Center for Genomics (ICG), Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, College of Chemistry, College of Engineering, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China

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Yanjiao Shao

4Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA

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Pu-Yao Zhang

5Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China

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Yanyi Huang

6Institute for Cell Analysis, Shenzhen Bay Laboratory, Shenzhen, China

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Yang Yu

5Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China

7Stem Cell Research Center, Peking University Third Hospital, Beijing 100191, China

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For correspondence: yuyang5012@hotmail.com Belmonte@salk.edu mo.li@kaust.edu.sa

Juan Carlos Izpisua Belmonte

4Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA

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For correspondence: yuyang5012@hotmail.com Belmonte@salk.edu mo.li@kaust.edu.sa

Mo Li

1Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia

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ORCID record for Mo Li
For correspondence: yuyang5012@hotmail.com Belmonte@salk.edu mo.li@kaust.edu.sa

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Single-cell Individual Complete mtDNA Sequencing Uncovers Hidden Mitochondrial Heterogeneity in Human and Mouse Oocytes

Chongwei Bi, Lin Wang, Yong Fan, Gerardo Ramos-Mandujano, Baolei Yuan, Xuan Zhou, Jincheng Wang, Yanjiao Shao, Pu-Yao Zhang, Yanyi Huang, Yang Yu, Juan Carlos Izpisua Belmonte, Mo Li

bioRxiv 2020.12.28.424537; doi: https://doi.org/10.1101/2020.12.28.424537

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Single-cell Individual Complete mtDNA Sequencing Uncovers Hidden Mitochondrial Heterogeneity in Human and Mouse Oocytes

Chongwei Bi, Lin Wang, Yong Fan, Gerardo Ramos-Mandujano, Baolei Yuan, Xuan Zhou, Jincheng Wang, Yanjiao Shao, Pu-Yao Zhang, Yanyi Huang, Yang Yu, Juan Carlos Izpisua Belmonte, Mo Li

bioRxiv 2020.12.28.424537; doi: https://doi.org/10.1101/2020.12.28.424537

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