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Host’s Specific SARS-CoV-2 Mutations: Insertion of the Phenylalanine in the NSP6 Linked to the United Kingdom and Premature Termination of the ORF-8 Associated with the European and the United States of America Derived Samples

View ORCID ProfileMohammad Khalid, Yousef Al-ebini, David Murphy, Maryam Shoai
doi: https://doi.org/10.1101/2020.12.29.424530
Mohammad Khalid
1Department of Pharmaceutics, College of Pharmacy, King Khalid University, Asir-Abha 61421, Saudi Arabia
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  • For correspondence: mmabood@kku.edu.sa 1khalidmd@gmail.com
Yousef Al-ebini
1Department of Pharmaceutics, College of Pharmacy, King Khalid University, Asir-Abha 61421, Saudi Arabia
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David Murphy
2Department of Clinical and Movement Neurosciences, UCL Institute of Neurology, Queen Square, London, United Kingdom
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Maryam Shoai
3Department of Neurodegenerative Diseases, UCL Institute of Neurology, London, United Kingdom
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Abstract

The coronavirus belongs to the order Nidovirales, which is known for the longest RNA genome virus. The polymerase enzyme of SARS-CoV-2 has proofreading functions, but still, the RNA viruses have a higher mutation rate than DNA viruses. The mutations in the viral genome provide a replication advantage in any population/geographical location and that may have profound consequences in the outcome and pathogenesis, diagnosis and patient management of the viral infection. In the present study, we have analysed full-length SARS-CoV-2 genome sequences, derived from symptomatic/asymptomatic COVID-19 patients from all six continents to investigate the common mutations globally. Our results revealed that SARS-CoV-2 is mutating independently, we identified total 313 mutations and some (21 mutations) of them are prevailing over time irrespective of geographical location. Another important finding, we are reporting here is, the mutation rate of the virus varies in different geographical locations suggesting the virus is adapting different strategies in the infected populations, having different genetic backgrounds across the globe. We have identified 11085TTT insertion (insertion of the Phenylalanine in NSP6 at position 38) mutation, which is mainly linked to the UK derived SARS-CoV-2 samples, we have also discovered non-sense mutation in ORF-8 after 17 amino acid is linked to the European and the USA derived SARS-CoV-2 samples.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • In the title of the manuscript, United Kingdom had an extra 'e' at end, that needed to be removed.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted January 04, 2021.
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Host’s Specific SARS-CoV-2 Mutations: Insertion of the Phenylalanine in the NSP6 Linked to the United Kingdom and Premature Termination of the ORF-8 Associated with the European and the United States of America Derived Samples
Mohammad Khalid, Yousef Al-ebini, David Murphy, Maryam Shoai
bioRxiv 2020.12.29.424530; doi: https://doi.org/10.1101/2020.12.29.424530
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Host’s Specific SARS-CoV-2 Mutations: Insertion of the Phenylalanine in the NSP6 Linked to the United Kingdom and Premature Termination of the ORF-8 Associated with the European and the United States of America Derived Samples
Mohammad Khalid, Yousef Al-ebini, David Murphy, Maryam Shoai
bioRxiv 2020.12.29.424530; doi: https://doi.org/10.1101/2020.12.29.424530

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