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Deep mining of early antibody response in COVID-19 patients yields potent neutralisers and reveals high level of convergence
Georgia Bullen, Jacob D. Galson, Pedro Villar, Lien Moreels, Line Ledsgaard, Giada Mattiuzzo, Gareth Hall, Emma M. Bentley, Edward W. Masters, David Tang, Sophie Millett, Danielle Tongue, Richard Brown, Ioannis Diamantopoulos, Kothai Parthiban, Claire Tebbutt, Rachael Leah, Krishna Chaitanya, Deividas Pazeraitis, Sachin B. Surade, Omodele Ashiru, Lucia Crippa, Richard Cowan, View ORCID ProfileMatthew W. Bowler, Jamie I. Campbell, Wing-Yiu Jason Lee, Mark D. Carr, David Matthews, Paul Pfeffer, Simon E. Hufton, Kovilen Sawmynaden, Jane Osbourn, John McCafferty, View ORCID ProfileAneesh Karatt-Vellatt
doi: https://doi.org/10.1101/2020.12.29.424711
Georgia Bullen
1IONTAS Ltd., Iconix Park, London, Pampisford, Cambridgeshire, CB22 3EG, United Kingdom
Jacob D. Galson
2Alchemab Therapeutics Ltd., 55-56 Russell Square, London, WC1B 4HP, United Kingdom
Pedro Villar
1IONTAS Ltd., Iconix Park, London, Pampisford, Cambridgeshire, CB22 3EG, United Kingdom
Lien Moreels
1IONTAS Ltd., Iconix Park, London, Pampisford, Cambridgeshire, CB22 3EG, United Kingdom
Line Ledsgaard
1IONTAS Ltd., Iconix Park, London, Pampisford, Cambridgeshire, CB22 3EG, United Kingdom
Giada Mattiuzzo
3National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, EN6 3QG, United Kingdom
Gareth Hall
4Department of Molecular and Cell Biology, Henry Wellcome Building, University of Leicester, University Road, Leicester, LE1 7RH, United Kingdom
Emma M. Bentley
3National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, EN6 3QG, United Kingdom
Edward W. Masters
1IONTAS Ltd., Iconix Park, London, Pampisford, Cambridgeshire, CB22 3EG, United Kingdom
David Tang
5LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, United Kingdom
Sophie Millett
5LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, United Kingdom
Danielle Tongue
5LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, United Kingdom
Richard Brown
5LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, United Kingdom
Ioannis Diamantopoulos
1IONTAS Ltd., Iconix Park, London, Pampisford, Cambridgeshire, CB22 3EG, United Kingdom
Kothai Parthiban
1IONTAS Ltd., Iconix Park, London, Pampisford, Cambridgeshire, CB22 3EG, United Kingdom
Claire Tebbutt
1IONTAS Ltd., Iconix Park, London, Pampisford, Cambridgeshire, CB22 3EG, United Kingdom
Rachael Leah
1IONTAS Ltd., Iconix Park, London, Pampisford, Cambridgeshire, CB22 3EG, United Kingdom
Krishna Chaitanya
1IONTAS Ltd., Iconix Park, London, Pampisford, Cambridgeshire, CB22 3EG, United Kingdom
Deividas Pazeraitis
1IONTAS Ltd., Iconix Park, London, Pampisford, Cambridgeshire, CB22 3EG, United Kingdom
Sachin B. Surade
1IONTAS Ltd., Iconix Park, London, Pampisford, Cambridgeshire, CB22 3EG, United Kingdom
Omodele Ashiru
6Abcam, Discovery Drive, Cambridge Biomedical Campus, Cambridgeshire, CB2 0AX, United Kingdom
Lucia Crippa
6Abcam, Discovery Drive, Cambridge Biomedical Campus, Cambridgeshire, CB2 0AX, United Kingdom
Richard Cowan
4Department of Molecular and Cell Biology, Henry Wellcome Building, University of Leicester, University Road, Leicester, LE1 7RH, United Kingdom
Matthew W. Bowler
7European Molecular Biology Laboratory, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble Cedex 9, France
Jamie I. Campbell
6Abcam, Discovery Drive, Cambridge Biomedical Campus, Cambridgeshire, CB2 0AX, United Kingdom
Wing-Yiu Jason Lee
8Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AD, United Kingdom
Mark D. Carr
4Department of Molecular and Cell Biology, Henry Wellcome Building, University of Leicester, University Road, Leicester, LE1 7RH, United Kingdom
David Matthews
5LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, United Kingdom
Paul Pfeffer
8Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AD, United Kingdom
Simon E. Hufton
3National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, EN6 3QG, United Kingdom
Kovilen Sawmynaden
5LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, United Kingdom
Jane Osbourn
2Alchemab Therapeutics Ltd., 55-56 Russell Square, London, WC1B 4HP, United Kingdom
John McCafferty
1IONTAS Ltd., Iconix Park, London, Pampisford, Cambridgeshire, CB22 3EG, United Kingdom
Aneesh Karatt-Vellatt
1IONTAS Ltd., Iconix Park, London, Pampisford, Cambridgeshire, CB22 3EG, United Kingdom
Article usage
Posted December 29, 2020.
Deep mining of early antibody response in COVID-19 patients yields potent neutralisers and reveals high level of convergence
Georgia Bullen, Jacob D. Galson, Pedro Villar, Lien Moreels, Line Ledsgaard, Giada Mattiuzzo, Gareth Hall, Emma M. Bentley, Edward W. Masters, David Tang, Sophie Millett, Danielle Tongue, Richard Brown, Ioannis Diamantopoulos, Kothai Parthiban, Claire Tebbutt, Rachael Leah, Krishna Chaitanya, Deividas Pazeraitis, Sachin B. Surade, Omodele Ashiru, Lucia Crippa, Richard Cowan, Matthew W. Bowler, Jamie I. Campbell, Wing-Yiu Jason Lee, Mark D. Carr, David Matthews, Paul Pfeffer, Simon E. Hufton, Kovilen Sawmynaden, Jane Osbourn, John McCafferty, Aneesh Karatt-Vellatt
bioRxiv 2020.12.29.424711; doi: https://doi.org/10.1101/2020.12.29.424711
Deep mining of early antibody response in COVID-19 patients yields potent neutralisers and reveals high level of convergence
Georgia Bullen, Jacob D. Galson, Pedro Villar, Lien Moreels, Line Ledsgaard, Giada Mattiuzzo, Gareth Hall, Emma M. Bentley, Edward W. Masters, David Tang, Sophie Millett, Danielle Tongue, Richard Brown, Ioannis Diamantopoulos, Kothai Parthiban, Claire Tebbutt, Rachael Leah, Krishna Chaitanya, Deividas Pazeraitis, Sachin B. Surade, Omodele Ashiru, Lucia Crippa, Richard Cowan, Matthew W. Bowler, Jamie I. Campbell, Wing-Yiu Jason Lee, Mark D. Carr, David Matthews, Paul Pfeffer, Simon E. Hufton, Kovilen Sawmynaden, Jane Osbourn, John McCafferty, Aneesh Karatt-Vellatt
bioRxiv 2020.12.29.424711; doi: https://doi.org/10.1101/2020.12.29.424711
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