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Locomotion-induced ocular motor behavior in larval Xenopus is developmentally tuned by visuo-vestibular reflexes

View ORCID ProfileJulien Bacqué-Cazenave, Gilles Courtand, View ORCID ProfileMathieu Beraneck, View ORCID ProfileHans Straka, Denis Combes, View ORCID ProfileFrançois M. Lambert
doi: https://doi.org/10.1101/2021.01.04.424105
Julien Bacqué-Cazenave
1INCIA, CNRS UMR 5287, Université de Bordeaux, F- 33076 Bordeaux, France
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  • ORCID record for Julien Bacqué-Cazenave
Gilles Courtand
1INCIA, CNRS UMR 5287, Université de Bordeaux, F- 33076 Bordeaux, France
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Mathieu Beraneck
2Université de Paris, Integrative Neuroscience and Cognition Center, CNRS UMR 8002, F-75270 Paris, France
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Hans Straka
3Department Biology II, Ludwig-Maximilians-University Munich, Grosshadernerstr. 2, 82152 Planegg, Germany
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Denis Combes
1INCIA, CNRS UMR 5287, Université de Bordeaux, F- 33076 Bordeaux, France
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François M. Lambert
1INCIA, CNRS UMR 5287, Université de Bordeaux, F- 33076 Bordeaux, France
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  • For correspondence: francois.lambert@u-bordeaux.fr
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ABSTRACT

Locomotion requires neural computations to maintain stable perception of the world despite disturbing consequences of the motor behavior on sensory stability. The developmental establishment of locomotor proficiency is therefore accompanied by a concurrent maturation of gaze-stabilizing motor behaviors. Using developing larval Xenopus, we demonstrate mutual plasticity of predictive spinal locomotor efference copies and multi-sensory motion signals with the aim to constantly ensure dynamically adequate eye movements during swimming. Following simultaneous ontogenetic onsets of locomotion, spino-ocular, optokinetic and otolith-ocular motor behaviors, locomotor efference copy-driven eye movements improve through gradually augmenting influences of semicircular canal signals. Accordingly, neuronal computations change from a predominating cancelation of angular vestibulo-ocular reflexes by locomotor efference copies in young larvae to a summation of these signals in older larvae. The developmental switch occurs in synchrony with a reduced efficacy of the tail-undulatory locomotor pattern generator causing gradually decaying influences on the ocular motor output.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted January 04, 2021.
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Locomotion-induced ocular motor behavior in larval Xenopus is developmentally tuned by visuo-vestibular reflexes
Julien Bacqué-Cazenave, Gilles Courtand, Mathieu Beraneck, Hans Straka, Denis Combes, François M. Lambert
bioRxiv 2021.01.04.424105; doi: https://doi.org/10.1101/2021.01.04.424105
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Locomotion-induced ocular motor behavior in larval Xenopus is developmentally tuned by visuo-vestibular reflexes
Julien Bacqué-Cazenave, Gilles Courtand, Mathieu Beraneck, Hans Straka, Denis Combes, François M. Lambert
bioRxiv 2021.01.04.424105; doi: https://doi.org/10.1101/2021.01.04.424105

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