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Immunogenicity of an AAV-based, room-temperature stable, single dose COVID-19 vaccine in mouse and non-human primates
Nerea Zabaleta, Wenlong Dai, Urja Bhatt, Jessica A Chichester, Julio Sanmiguel, Reynette Estelien, Kristofer T Michalson, Cheikh Diop, Dawid Maciorowski, Wenbin Qi, Elissa Hudspeth, Allison Cucalon, Cecilia D Dyer, M. Betina Pampena, James J. Knox, Regina C LaRocque, Richelle C Charles, Dan Li, Maya Kim, Abigail Sheridan, Nadia Storm, Rebecca I Johnson, Jared Feldman, View ORCID ProfileBlake M Hauser, Eric Zinn, Aisling Ryan, Dione T Kobayashi, Ruchi Chauhan, Marion McGlynn, Edward T Ryan, Aaron G Schmidt, Brian Price, Anna Honko, Anthony Griffiths, Sam Yaghmour, Robert Hodge, Michael R. Betts, Mason W Freeman, James M Wilson, Luk H Vandenberghe
doi: https://doi.org/10.1101/2021.01.05.422952
Nerea Zabaleta
1Grousbeck Gene Therapy Center, Schepens Eye Research Institute, Mass Eye and Ear, Boston, Massachusetts, USA
2Ocular Genomics Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
3The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
4Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA
Wenlong Dai
1Grousbeck Gene Therapy Center, Schepens Eye Research Institute, Mass Eye and Ear, Boston, Massachusetts, USA
2Ocular Genomics Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
3The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
4Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA
Urja Bhatt
1Grousbeck Gene Therapy Center, Schepens Eye Research Institute, Mass Eye and Ear, Boston, Massachusetts, USA
2Ocular Genomics Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
3The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
4Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA
Jessica A Chichester
5Gene Therapy Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Julio Sanmiguel
1Grousbeck Gene Therapy Center, Schepens Eye Research Institute, Mass Eye and Ear, Boston, Massachusetts, USA
2Ocular Genomics Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
3The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
4Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA
Reynette Estelien
1Grousbeck Gene Therapy Center, Schepens Eye Research Institute, Mass Eye and Ear, Boston, Massachusetts, USA
2Ocular Genomics Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
3The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
4Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA
Kristofer T Michalson
5Gene Therapy Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Cheikh Diop
1Grousbeck Gene Therapy Center, Schepens Eye Research Institute, Mass Eye and Ear, Boston, Massachusetts, USA
2Ocular Genomics Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
3The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
4Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA
Dawid Maciorowski
1Grousbeck Gene Therapy Center, Schepens Eye Research Institute, Mass Eye and Ear, Boston, Massachusetts, USA
2Ocular Genomics Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
3The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
4Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA
Wenbin Qi
6Novartis Gene Therapies, San Diego, California, USA
Elissa Hudspeth
7Novartis Gene Therapies, North Carolina, USA
Allison Cucalon
1Grousbeck Gene Therapy Center, Schepens Eye Research Institute, Mass Eye and Ear, Boston, Massachusetts, USA
2Ocular Genomics Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
3The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
4Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA
Cecilia D Dyer
5Gene Therapy Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
M. Betina Pampena
5Gene Therapy Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
8Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
James J. Knox
9Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Regina C LaRocque
10Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA
11Department of Medicine, Harvard Medical School, Boston, MA
Richelle C Charles
10Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA
11Department of Medicine, Harvard Medical School, Boston, MA
Dan Li
1Grousbeck Gene Therapy Center, Schepens Eye Research Institute, Mass Eye and Ear, Boston, Massachusetts, USA
2Ocular Genomics Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
3The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
4Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA
Maya Kim
1Grousbeck Gene Therapy Center, Schepens Eye Research Institute, Mass Eye and Ear, Boston, Massachusetts, USA
2Ocular Genomics Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
3The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
4Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA
Abigail Sheridan
1Grousbeck Gene Therapy Center, Schepens Eye Research Institute, Mass Eye and Ear, Boston, Massachusetts, USA
2Ocular Genomics Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
3The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
4Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA
Nadia Storm
12Department of Microbiology and National Emerging Infectious Diseases Laboratories, Boston University School of Medicine, Boston, MA 02118, United States
Rebecca I Johnson
12Department of Microbiology and National Emerging Infectious Diseases Laboratories, Boston University School of Medicine, Boston, MA 02118, United States
Jared Feldman
13Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, 02139, USA
Blake M Hauser
13Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, 02139, USA
Eric Zinn
1Grousbeck Gene Therapy Center, Schepens Eye Research Institute, Mass Eye and Ear, Boston, Massachusetts, USA
2Ocular Genomics Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
3The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
4Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA
Aisling Ryan
1Grousbeck Gene Therapy Center, Schepens Eye Research Institute, Mass Eye and Ear, Boston, Massachusetts, USA
2Ocular Genomics Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
3The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
4Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA
Dione T Kobayashi
14Translational Innovation Fund, Mass General Brigham Innovation, Cambridge, Massachusetts, USA
Ruchi Chauhan
1Grousbeck Gene Therapy Center, Schepens Eye Research Institute, Mass Eye and Ear, Boston, Massachusetts, USA
2Ocular Genomics Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
3The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
4Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA
Marion McGlynn
5Gene Therapy Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Edward T Ryan
10Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA
11Department of Medicine, Harvard Medical School, Boston, MA
15Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA
Aaron G Schmidt
13Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, 02139, USA
16Department of Microbiology, Harvard Medical School, Boston, MA, USA
Brian Price
17Albamunity, Boston, Massachusetts, USA
Anna Honko
12Department of Microbiology and National Emerging Infectious Diseases Laboratories, Boston University School of Medicine, Boston, MA 02118, United States
Anthony Griffiths
12Department of Microbiology and National Emerging Infectious Diseases Laboratories, Boston University School of Medicine, Boston, MA 02118, United States
Sam Yaghmour
6Novartis Gene Therapies, San Diego, California, USA
Robert Hodge
18Novartis Gene Therapies, Libertyville, Illinois, USA
Michael R. Betts
5Gene Therapy Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
8Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Mason W Freeman
19Center for Computational & Integrative Biology, Department of Medicine, and Translational Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
James M Wilson
5Gene Therapy Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Luk H Vandenberghe
1Grousbeck Gene Therapy Center, Schepens Eye Research Institute, Mass Eye and Ear, Boston, Massachusetts, USA
2Ocular Genomics Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
3The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
4Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA
Article usage
Posted January 19, 2021.
Immunogenicity of an AAV-based, room-temperature stable, single dose COVID-19 vaccine in mouse and non-human primates
Nerea Zabaleta, Wenlong Dai, Urja Bhatt, Jessica A Chichester, Julio Sanmiguel, Reynette Estelien, Kristofer T Michalson, Cheikh Diop, Dawid Maciorowski, Wenbin Qi, Elissa Hudspeth, Allison Cucalon, Cecilia D Dyer, M. Betina Pampena, James J. Knox, Regina C LaRocque, Richelle C Charles, Dan Li, Maya Kim, Abigail Sheridan, Nadia Storm, Rebecca I Johnson, Jared Feldman, Blake M Hauser, Eric Zinn, Aisling Ryan, Dione T Kobayashi, Ruchi Chauhan, Marion McGlynn, Edward T Ryan, Aaron G Schmidt, Brian Price, Anna Honko, Anthony Griffiths, Sam Yaghmour, Robert Hodge, Michael R. Betts, Mason W Freeman, James M Wilson, Luk H Vandenberghe
bioRxiv 2021.01.05.422952; doi: https://doi.org/10.1101/2021.01.05.422952
Immunogenicity of an AAV-based, room-temperature stable, single dose COVID-19 vaccine in mouse and non-human primates
Nerea Zabaleta, Wenlong Dai, Urja Bhatt, Jessica A Chichester, Julio Sanmiguel, Reynette Estelien, Kristofer T Michalson, Cheikh Diop, Dawid Maciorowski, Wenbin Qi, Elissa Hudspeth, Allison Cucalon, Cecilia D Dyer, M. Betina Pampena, James J. Knox, Regina C LaRocque, Richelle C Charles, Dan Li, Maya Kim, Abigail Sheridan, Nadia Storm, Rebecca I Johnson, Jared Feldman, Blake M Hauser, Eric Zinn, Aisling Ryan, Dione T Kobayashi, Ruchi Chauhan, Marion McGlynn, Edward T Ryan, Aaron G Schmidt, Brian Price, Anna Honko, Anthony Griffiths, Sam Yaghmour, Robert Hodge, Michael R. Betts, Mason W Freeman, James M Wilson, Luk H Vandenberghe
bioRxiv 2021.01.05.422952; doi: https://doi.org/10.1101/2021.01.05.422952
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