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Network Analysis Reveals Synergistic Genetic Dependencies for Rational Combination Therapy in Philadelphia Chromosome-like Acute Lymphoblastic Leukemia
Yang-Yang Ding, Hannah Kim, Kellyn Madden, Joseph P Loftus, Gregory M Chen, David Hottman Allen, Ruitao Zhang, Jason Xu, Yuxuan Hu, Sarah K Tasian, View ORCID ProfileKai Tan
doi: https://doi.org/10.1101/2021.01.06.425608
Yang-Yang Ding
1Center for Childhood Cancer Research, Children’s Hospital of Philadelphia; Philadelphia, Pennsylvania 19104, USA
2Department of Pediatrics, University of Pennsylvania; Philadelphia, Pennsylvania 19104, USA
3Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia; Philadelphia, Pennsylvania 19104, USA
Hannah Kim
4Institute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA, USA
Kellyn Madden
1Center for Childhood Cancer Research, Children’s Hospital of Philadelphia; Philadelphia, Pennsylvania 19104, USA
Joseph P Loftus
1Center for Childhood Cancer Research, Children’s Hospital of Philadelphia; Philadelphia, Pennsylvania 19104, USA
Gregory M Chen
5Graduate Group in Genomics and Computational Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
David Hottman Allen
1Center for Childhood Cancer Research, Children’s Hospital of Philadelphia; Philadelphia, Pennsylvania 19104, USA
Ruitao Zhang
1Center for Childhood Cancer Research, Children’s Hospital of Philadelphia; Philadelphia, Pennsylvania 19104, USA
Jason Xu
5Graduate Group in Genomics and Computational Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
Yuxuan Hu
6School of Computer Science and Technology, Xidian University, Xi’an, Shaanxi 710071, China
Sarah K Tasian
1Center for Childhood Cancer Research, Children’s Hospital of Philadelphia; Philadelphia, Pennsylvania 19104, USA
2Department of Pediatrics, University of Pennsylvania; Philadelphia, Pennsylvania 19104, USA
7Abramson Cancer Center, University of Pennsylvania; Philadelphia, Pennsylvania 19104, USA
Kai Tan
1Center for Childhood Cancer Research, Children’s Hospital of Philadelphia; Philadelphia, Pennsylvania 19104, USA
2Department of Pediatrics, University of Pennsylvania; Philadelphia, Pennsylvania 19104, USA
3Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia; Philadelphia, Pennsylvania 19104, USA
7Abramson Cancer Center, University of Pennsylvania; Philadelphia, Pennsylvania 19104, USA
Article usage
Posted January 08, 2021.
Network Analysis Reveals Synergistic Genetic Dependencies for Rational Combination Therapy in Philadelphia Chromosome-like Acute Lymphoblastic Leukemia
Yang-Yang Ding, Hannah Kim, Kellyn Madden, Joseph P Loftus, Gregory M Chen, David Hottman Allen, Ruitao Zhang, Jason Xu, Yuxuan Hu, Sarah K Tasian, Kai Tan
bioRxiv 2021.01.06.425608; doi: https://doi.org/10.1101/2021.01.06.425608
Network Analysis Reveals Synergistic Genetic Dependencies for Rational Combination Therapy in Philadelphia Chromosome-like Acute Lymphoblastic Leukemia
Yang-Yang Ding, Hannah Kim, Kellyn Madden, Joseph P Loftus, Gregory M Chen, David Hottman Allen, Ruitao Zhang, Jason Xu, Yuxuan Hu, Sarah K Tasian, Kai Tan
bioRxiv 2021.01.06.425608; doi: https://doi.org/10.1101/2021.01.06.425608
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